Sigma-1 Receptor and Binding Immunoglobulin Protein Interact with Ulinastatin Contributing to a Protective Effect in Rat Cerebral Ischemia/Reperfusion

To investigate impact of ulinastatin (UTI) on sigma-1 receptor (σ1R) and binding immunoglobulin protein (BiP) after cerebral ischemia/reperfusion injury. The middle cerebral artery occlusion (MCAO) model was used to induce cerebral ischemia/reperfusion injury. Eighty male Sprague Dawley rats were ra...

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Veröffentlicht in:	World neurosurgery 2022-02, Vol.158, p.e488-e494
Hauptverfasser:	Dai, Ling-Ao, Chen, Xiao-Yin, Li, Wen-Jing, Yang, Jia-Hao, Lin, Ming-Jie, Li, Xiao-Shan, Zeng, Yu-Fu, Chen, Shu-Wen, Xie, Zhu-Liang, Zhu, Zhuo-Li, Li, Xiong-Juan, Huang, Huan-Sen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding immunoglobulin protein Brain Ischemia - drug therapy Cerebral ischemia-reperfusion injury Glycoproteins Heat-Shock Proteins - metabolism Immunoglobulins - metabolism Immunoglobulins - therapeutic use Infarction, Middle Cerebral Artery - drug therapy Male Molecular Docking Simulation Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Rats Rats, Sprague-Dawley Receptors, sigma - metabolism Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Reperfusion Injury - prevention & control Sigma-1 Receptor Ulinastatin
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