Evaluation of levocarnitine, lactulose, and combination therapy for the treatment of valproic acid-induced hyperammonemia in critically ill patients

Critically ill patients treated with valproic acid are at risk for hyperammonemic encephalopathy. Both levocarnitine and lactulose, either alone or in combination, have been used for the treatment of hyperammonemia associated with valproic acid, however they have not been directly compared in the li...

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Veröffentlicht in:	Epilepsy research 2021-12, Vol.178, p.106806-106806, Article 106806
Hauptverfasser:	Nicholson, Carli, Fowler, Melissa, Mullen, Chanda, Cunningham, Brittany
Format:	Artikel
Sprache:	eng
Schlagworte:	Carnitine - therapeutic use Cohort Studies Critical care Critical Illness Encephalopathy Humans Hyperammonemia Hyperammonemia - chemically induced Hyperammonemia - drug therapy Lactulose Lactulose - therapeutic use Levocarnitine Retrospective Studies Valproic acid Valproic Acid - adverse effects
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