Structurally screening calixarenes as peptide transport activators
Calixarenes are reportedly excellent activators that can remarkably improve the transport efficiencies of cell penetrating peptides. We employed eight calixarenes to systematically study the influence of structure on activation efficiency, which revealed that the scaffold, head group, and alkyl chai...
Gespeichert in:
| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2021-11, Vol.57 (94), p.12627-1263 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1263 |
|---|---|
| container_issue | 94 |
| container_start_page | 12627 |
| container_title | Chemical communications (Cambridge, England) |
| container_volume | 57 |
| creator | Zhang, De-Yi Zheng, Zhe Zhao, Hong Wang, Huan-Yu Ding, Fei Li, Hua-Bin Pan, Yu-Chen Guo, Dong-Sheng |
| description | Calixarenes are reportedly excellent activators that can remarkably improve the transport efficiencies of cell penetrating peptides. We employed eight calixarenes to systematically study the influence of structure on activation efficiency, which revealed that the scaffold, head group, and alkyl chain are all significant factors for activation efficiency by affecting affinities with the peptide and membrane.
We studied the influence of calixarene structure on transport efficiency of peptides, and provide meaningful information for transport systems. |
| doi_str_mv | 10.1039/d1cc05414g |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_2596456118</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2602286772</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-4db670049d85241aa1fbab90fcda24cca3f0176533e5ddbf26004b2d4450971b3</originalsourceid><addsrcrecordid>eNpd0c1LwzAYBvAgitPpxbtS8CJCNd9pj1p1CgMPKngLaZKOjq6tSSruvzdzc4K5JPD-eHh5AsAJglcIkvzaIK0ho4jOdsABIpymjGbvu6s3y1NBKBuBQ-_nMB7Esn0wIlRwJDg-ALcvwQ06DE41zTLx2lnb1u0s0aqpv5SzrfWJ8klv-1AbmwSnWt93LiRKh_pThc75I7BXqcbb4809Bm8P96_FYzp9njwVN9NUEyJCSk3JBYQ0NxnDFCmFqlKVOay0UZhqrUgF406MEMuMKSvMIy6xoZTBXKCSjMHFOrd33cdgfZCL2mvbNKq13eAlZjmnjCOURXr-j867wbVxOxljMc64EDiqy7XSrvPe2Ur2rl4ot5QIylWz8g4VxU-zk4jPNpFDubBmS3-rjOB0DZzX2-nf15BvI2Z9Iw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2602286772</pqid></control><display><type>article</type><title>Structurally screening calixarenes as peptide transport activators</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Zhang, De-Yi ; Zheng, Zhe ; Zhao, Hong ; Wang, Huan-Yu ; Ding, Fei ; Li, Hua-Bin ; Pan, Yu-Chen ; Guo, Dong-Sheng</creator><creatorcontrib>Zhang, De-Yi ; Zheng, Zhe ; Zhao, Hong ; Wang, Huan-Yu ; Ding, Fei ; Li, Hua-Bin ; Pan, Yu-Chen ; Guo, Dong-Sheng</creatorcontrib><description>Calixarenes are reportedly excellent activators that can remarkably improve the transport efficiencies of cell penetrating peptides. We employed eight calixarenes to systematically study the influence of structure on activation efficiency, which revealed that the scaffold, head group, and alkyl chain are all significant factors for activation efficiency by affecting affinities with the peptide and membrane.
We studied the influence of calixarene structure on transport efficiency of peptides, and provide meaningful information for transport systems.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/d1cc05414g</identifier><identifier>PMID: 34761762</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Biological Transport - drug effects ; Calixarenes ; Calixarenes - chemistry ; Calixarenes - pharmacology ; Drug Evaluation, Preclinical ; Humans ; Molecular Structure ; Peptides ; Peptides - metabolism</subject><ispartof>Chemical communications (Cambridge, England), 2021-11, Vol.57 (94), p.12627-1263</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-4db670049d85241aa1fbab90fcda24cca3f0176533e5ddbf26004b2d4450971b3</citedby><cites>FETCH-LOGICAL-c337t-4db670049d85241aa1fbab90fcda24cca3f0176533e5ddbf26004b2d4450971b3</cites><orcidid>0000-0002-0765-5427</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34761762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, De-Yi</creatorcontrib><creatorcontrib>Zheng, Zhe</creatorcontrib><creatorcontrib>Zhao, Hong</creatorcontrib><creatorcontrib>Wang, Huan-Yu</creatorcontrib><creatorcontrib>Ding, Fei</creatorcontrib><creatorcontrib>Li, Hua-Bin</creatorcontrib><creatorcontrib>Pan, Yu-Chen</creatorcontrib><creatorcontrib>Guo, Dong-Sheng</creatorcontrib><title>Structurally screening calixarenes as peptide transport activators</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>Calixarenes are reportedly excellent activators that can remarkably improve the transport efficiencies of cell penetrating peptides. We employed eight calixarenes to systematically study the influence of structure on activation efficiency, which revealed that the scaffold, head group, and alkyl chain are all significant factors for activation efficiency by affecting affinities with the peptide and membrane.
We studied the influence of calixarene structure on transport efficiency of peptides, and provide meaningful information for transport systems.</description><subject>Biological Transport - drug effects</subject><subject>Calixarenes</subject><subject>Calixarenes - chemistry</subject><subject>Calixarenes - pharmacology</subject><subject>Drug Evaluation, Preclinical</subject><subject>Humans</subject><subject>Molecular Structure</subject><subject>Peptides</subject><subject>Peptides - metabolism</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0c1LwzAYBvAgitPpxbtS8CJCNd9pj1p1CgMPKngLaZKOjq6tSSruvzdzc4K5JPD-eHh5AsAJglcIkvzaIK0ho4jOdsABIpymjGbvu6s3y1NBKBuBQ-_nMB7Esn0wIlRwJDg-ALcvwQ06DE41zTLx2lnb1u0s0aqpv5SzrfWJ8klv-1AbmwSnWt93LiRKh_pThc75I7BXqcbb4809Bm8P96_FYzp9njwVN9NUEyJCSk3JBYQ0NxnDFCmFqlKVOay0UZhqrUgF406MEMuMKSvMIy6xoZTBXKCSjMHFOrd33cdgfZCL2mvbNKq13eAlZjmnjCOURXr-j867wbVxOxljMc64EDiqy7XSrvPe2Ur2rl4ot5QIylWz8g4VxU-zk4jPNpFDubBmS3-rjOB0DZzX2-nf15BvI2Z9Iw</recordid><startdate>20211125</startdate><enddate>20211125</enddate><creator>Zhang, De-Yi</creator><creator>Zheng, Zhe</creator><creator>Zhao, Hong</creator><creator>Wang, Huan-Yu</creator><creator>Ding, Fei</creator><creator>Li, Hua-Bin</creator><creator>Pan, Yu-Chen</creator><creator>Guo, Dong-Sheng</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0765-5427</orcidid></search><sort><creationdate>20211125</creationdate><title>Structurally screening calixarenes as peptide transport activators</title><author>Zhang, De-Yi ; Zheng, Zhe ; Zhao, Hong ; Wang, Huan-Yu ; Ding, Fei ; Li, Hua-Bin ; Pan, Yu-Chen ; Guo, Dong-Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-4db670049d85241aa1fbab90fcda24cca3f0176533e5ddbf26004b2d4450971b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biological Transport - drug effects</topic><topic>Calixarenes</topic><topic>Calixarenes - chemistry</topic><topic>Calixarenes - pharmacology</topic><topic>Drug Evaluation, Preclinical</topic><topic>Humans</topic><topic>Molecular Structure</topic><topic>Peptides</topic><topic>Peptides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, De-Yi</creatorcontrib><creatorcontrib>Zheng, Zhe</creatorcontrib><creatorcontrib>Zhao, Hong</creatorcontrib><creatorcontrib>Wang, Huan-Yu</creatorcontrib><creatorcontrib>Ding, Fei</creatorcontrib><creatorcontrib>Li, Hua-Bin</creatorcontrib><creatorcontrib>Pan, Yu-Chen</creatorcontrib><creatorcontrib>Guo, Dong-Sheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, De-Yi</au><au>Zheng, Zhe</au><au>Zhao, Hong</au><au>Wang, Huan-Yu</au><au>Ding, Fei</au><au>Li, Hua-Bin</au><au>Pan, Yu-Chen</au><au>Guo, Dong-Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structurally screening calixarenes as peptide transport activators</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2021-11-25</date><risdate>2021</risdate><volume>57</volume><issue>94</issue><spage>12627</spage><epage>1263</epage><pages>12627-1263</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>Calixarenes are reportedly excellent activators that can remarkably improve the transport efficiencies of cell penetrating peptides. We employed eight calixarenes to systematically study the influence of structure on activation efficiency, which revealed that the scaffold, head group, and alkyl chain are all significant factors for activation efficiency by affecting affinities with the peptide and membrane.
We studied the influence of calixarene structure on transport efficiency of peptides, and provide meaningful information for transport systems.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>34761762</pmid><doi>10.1039/d1cc05414g</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-0765-5427</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2021-11, Vol.57 (94), p.12627-1263 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2596456118 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Biological Transport - drug effects Calixarenes Calixarenes - chemistry Calixarenes - pharmacology Drug Evaluation, Preclinical Humans Molecular Structure Peptides Peptides - metabolism |
| title | Structurally screening calixarenes as peptide transport activators |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T22%3A47%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Structurally%20screening%20calixarenes%20as%20peptide%20transport%20activators&rft.jtitle=Chemical%20communications%20(Cambridge,%20England)&rft.au=Zhang,%20De-Yi&rft.date=2021-11-25&rft.volume=57&rft.issue=94&rft.spage=12627&rft.epage=1263&rft.pages=12627-1263&rft.issn=1359-7345&rft.eissn=1364-548X&rft_id=info:doi/10.1039/d1cc05414g&rft_dat=%3Cproquest_pubme%3E2602286772%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2602286772&rft_id=info:pmid/34761762&rfr_iscdi=true |