Acidic microenvironment enhances MT1-MMP-mediated cancer cell motility through integrin β1/cofilin/F-actin axis

Abstract Tumor acidic microenvironment is the main feature of many solid tumors. As a part of the tumor microenvironment, it has a profound impact on the occurrence and development of tumors. However, the research on how tumor cells sense the changes of the external microenvironment and how the intr...

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Veröffentlicht in:	Acta biochimica et biophysica Sinica 2021-11, Vol.53 (11), p.1558-1566
Hauptverfasser:	Liang, Lubiao, Sui, Ran, Song, Yongxiang, Zhao, Yajin
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Actin Cytoskeleton - genetics Actin Cytoskeleton - metabolism Actin Cytoskeleton - ultrastructure Actin Depolymerizing Factors - genetics Actin Depolymerizing Factors - metabolism Actins - genetics Actins - metabolism Cell Movement - genetics Extracellular Matrix - genetics Extracellular Matrix - metabolism Extracellular Matrix - ultrastructure Gene Expression Regulation, Neoplastic Humans Hydrogen-Ion Concentration Integrin beta1 - genetics Integrin beta1 - metabolism Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 1 - metabolism Models, Biological Signal Transduction Tumor Microenvironment - genetics
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