Identification of Highly Potent α‐Glucosidase Inhibitors from Artocarpus integer and Molecular Docking Studies

A new natural Diels‐Alder adduct (3) was isolated from the leaves and stem bark of Artocarpus integer, along with seventeen known compounds (1, 2, and 4–18). Structural elucidation was conducted using NMR and HR‐ESI‐MS data, and comparisons were made with previous studies. Deoxyartonin I (3) exhibit...

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Veröffentlicht in:	Chemistry & biodiversity 2021-12, Vol.18 (12), p.e2100499-n/a
Hauptverfasser:	Duong, Thuc‐Huy, Nguyen, Huy Troung, Nguyen, Chuong Hoang, Tran, Nguyen‐Minh‐An, Danova, Ade, Tran, Thi‐Minh‐Dinh, Vu‐Huynh, Kim Long, Musa, Vassana, Jutakanoke, Rumpa, Nguyen, Ngoc‐Hong, Sichaem, Jirapast
Format:	Artikel
Sprache:	eng
Schlagworte:	Acarbose alpha-Glucosidases - metabolism Artocarpus - chemistry Artocarpus integer Bark Diabetes mellitus Dose-Response Relationship, Drug Glucosidase Glycoside Hydrolase Inhibitors - chemistry Glycoside Hydrolase Inhibitors - isolation & purification Glycoside Hydrolase Inhibitors - pharmacology Humans Integers Molecular docking molecular docking model Molecular Docking Simulation Moraceae NMR Nuclear magnetic resonance Pharmacokinetics Plant Components, Aerial - chemistry Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology α-glucosidase inhibition
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