Nicaraven prevents the fast growth of inflamed tumors by an anti-inflammatory mechanism
Inflammatory microenvironment is known to accelerate the progression of malignant tumors. We investigated the possible anti-inflammatory effect of nicaraven on slowing tumor growth. Tumor-bearing mice randomly received nicaraven injection (50 mg/kg daily, i.p, n = 8) or placebo treatment ( n = 8)...
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| Veröffentlicht in: | Medical oncology (Northwood, London, England) London, England), 2022-01, Vol.39 (1), p.7-7, Article 7 |
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| creator | Abdelghany, Lina Zhang, Xu Kawabata, Tsuyoshi Goto, Shinji El-Mahdy, Nageh Jingu, Keiichi Li, Tao-Sheng |
| description | Inflammatory microenvironment is known to accelerate the progression of malignant tumors. We investigated the possible anti-inflammatory effect of nicaraven on slowing tumor growth. Tumor-bearing mice randomly received nicaraven injection (50 mg/kg daily, i.p,
n
= 8) or placebo treatment (
n
= 8) for 10 days, and then sacrificed for evaluations. Nicaraven administration effectively inhibited the fast growth of tumor, as a large tumor (> 1.0 g) developed finally in three of the eight mice received placebo treatment. Cytokines/chemokines array indicated that nicaraven reduced the levels of CXCL10 and SDF-1 in the tumor as well as the levels of IL-2 and MIP-2 in serum. Immunofluorescence staining showed that nicaraven significantly reduced the recruitment of macrophages and neutrophils in the tumor. Interestingly, western blot indicated that the expression of CD86, CD206, and NIMP-R14 was especially enhanced in the three large-size tumors, suggesting the potential role of nicaraven in preventing the hyper-inflammatory tumor microenvironment. Moreover, the expression of PARP-1 was downregulated, but the expression of phospho-p38 MAPK, phospho-MKK-3/6, and phospho-MSK-1 was upregulated in the large-size tumors, suggesting the involvement of p38 MAPK pathway in the anti-inflammatory effect of nicaraven. Taken together, our study suggests that nicaraven may effectively prevent the fast growth of inflamed tumors by an anti-inflammatory mechanism. |
| doi_str_mv | 10.1007/s12032-021-01602-x |
| format | Article |
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n
= 8) or placebo treatment (
n
= 8) for 10 days, and then sacrificed for evaluations. Nicaraven administration effectively inhibited the fast growth of tumor, as a large tumor (> 1.0 g) developed finally in three of the eight mice received placebo treatment. Cytokines/chemokines array indicated that nicaraven reduced the levels of CXCL10 and SDF-1 in the tumor as well as the levels of IL-2 and MIP-2 in serum. Immunofluorescence staining showed that nicaraven significantly reduced the recruitment of macrophages and neutrophils in the tumor. Interestingly, western blot indicated that the expression of CD86, CD206, and NIMP-R14 was especially enhanced in the three large-size tumors, suggesting the potential role of nicaraven in preventing the hyper-inflammatory tumor microenvironment. Moreover, the expression of PARP-1 was downregulated, but the expression of phospho-p38 MAPK, phospho-MKK-3/6, and phospho-MSK-1 was upregulated in the large-size tumors, suggesting the involvement of p38 MAPK pathway in the anti-inflammatory effect of nicaraven. Taken together, our study suggests that nicaraven may effectively prevent the fast growth of inflamed tumors by an anti-inflammatory mechanism.</description><identifier>ISSN: 1357-0560</identifier><identifier>EISSN: 1559-131X</identifier><identifier>DOI: 10.1007/s12032-021-01602-x</identifier><identifier>PMID: 34761342</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Anti-Inflammatory Agents - pharmacology ; Biomarkers, Tumor - metabolism ; Cytokines - metabolism ; Hematology ; Humans ; Inflammation - metabolism ; Internal Medicine ; Macrophages - drug effects ; Male ; Medicine ; Medicine & Public Health ; Mice ; Mice, Inbred C57BL ; Neoplasms - metabolism ; Neoplasms - pathology ; Niacinamide - analogs & derivatives ; Niacinamide - pharmacology ; Oncology ; Original Paper ; Pathology ; Tumor Microenvironment - drug effects ; Tumors</subject><ispartof>Medical oncology (Northwood, London, England), 2022-01, Vol.39 (1), p.7-7, Article 7</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-15330fefd7a7bc9ad512864e1e9cebf6cc89d6176b23872a3f714633d934810c3</citedby><cites>FETCH-LOGICAL-c375t-15330fefd7a7bc9ad512864e1e9cebf6cc89d6176b23872a3f714633d934810c3</cites><orcidid>0000-0002-7653-8873</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12032-021-01602-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12032-021-01602-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34761342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdelghany, Lina</creatorcontrib><creatorcontrib>Zhang, Xu</creatorcontrib><creatorcontrib>Kawabata, Tsuyoshi</creatorcontrib><creatorcontrib>Goto, Shinji</creatorcontrib><creatorcontrib>El-Mahdy, Nageh</creatorcontrib><creatorcontrib>Jingu, Keiichi</creatorcontrib><creatorcontrib>Li, Tao-Sheng</creatorcontrib><title>Nicaraven prevents the fast growth of inflamed tumors by an anti-inflammatory mechanism</title><title>Medical oncology (Northwood, London, England)</title><addtitle>Med Oncol</addtitle><addtitle>Med Oncol</addtitle><description>Inflammatory microenvironment is known to accelerate the progression of malignant tumors. We investigated the possible anti-inflammatory effect of nicaraven on slowing tumor growth. Tumor-bearing mice randomly received nicaraven injection (50 mg/kg daily, i.p,
n
= 8) or placebo treatment (
n
= 8) for 10 days, and then sacrificed for evaluations. Nicaraven administration effectively inhibited the fast growth of tumor, as a large tumor (> 1.0 g) developed finally in three of the eight mice received placebo treatment. Cytokines/chemokines array indicated that nicaraven reduced the levels of CXCL10 and SDF-1 in the tumor as well as the levels of IL-2 and MIP-2 in serum. Immunofluorescence staining showed that nicaraven significantly reduced the recruitment of macrophages and neutrophils in the tumor. Interestingly, western blot indicated that the expression of CD86, CD206, and NIMP-R14 was especially enhanced in the three large-size tumors, suggesting the potential role of nicaraven in preventing the hyper-inflammatory tumor microenvironment. Moreover, the expression of PARP-1 was downregulated, but the expression of phospho-p38 MAPK, phospho-MKK-3/6, and phospho-MSK-1 was upregulated in the large-size tumors, suggesting the involvement of p38 MAPK pathway in the anti-inflammatory effect of nicaraven. Taken together, our study suggests that nicaraven may effectively prevent the fast growth of inflamed tumors by an anti-inflammatory mechanism.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cytokines - metabolism</subject><subject>Hematology</subject><subject>Humans</subject><subject>Inflammation - metabolism</subject><subject>Internal Medicine</subject><subject>Macrophages - drug effects</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Niacinamide - analogs & derivatives</subject><subject>Niacinamide - pharmacology</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Pathology</subject><subject>Tumor Microenvironment - drug effects</subject><subject>Tumors</subject><issn>1357-0560</issn><issn>1559-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kMlKBDEQhoMozjj6Ah4k4MVLNEsn6T6KuIHoRdFbSKcTp6WXMUnrzNubsV3AgxCoQH31V_EBsE_wMcFYngRCMaMIU4IwEZii5QaYEs4LRBh52kx_xiXCXOAJ2AnhBSeS02IbTFgmBWEZnYLH29por99sBxfephIDjHMLnQ4RPvv-Pc5h72DduUa3toJxaHsfYLmCuksv1mhstTr2fgVba-a6q0O7C7acboLd-6oz8HBxfn92hW7uLq_PTm-QYZJHRDhj2FlXSS1LU-iKE5qLzBJbGFs6YUxeVIJIUVKWS6qZkyQTjFUFy3KCDZuBozF34fvXwYao2joY2zS6s_0QFOWFyHgmc5nQwz_oSz_4Ll23priUxfqaGaAjZXwfgrdOLXzdar9SBKu1djVqV0mm-tSulmno4Ct6KJOln5FvzwlgIxBSq3u2_nf3P7EfwUeN0g</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Abdelghany, Lina</creator><creator>Zhang, Xu</creator><creator>Kawabata, Tsuyoshi</creator><creator>Goto, Shinji</creator><creator>El-Mahdy, Nageh</creator><creator>Jingu, Keiichi</creator><creator>Li, Tao-Sheng</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7653-8873</orcidid></search><sort><creationdate>20220101</creationdate><title>Nicaraven prevents the fast growth of inflamed tumors by an anti-inflammatory mechanism</title><author>Abdelghany, Lina ; Zhang, Xu ; Kawabata, Tsuyoshi ; Goto, Shinji ; El-Mahdy, Nageh ; Jingu, Keiichi ; Li, Tao-Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-15330fefd7a7bc9ad512864e1e9cebf6cc89d6176b23872a3f714633d934810c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cytokines - metabolism</topic><topic>Hematology</topic><topic>Humans</topic><topic>Inflammation - metabolism</topic><topic>Internal Medicine</topic><topic>Macrophages - drug effects</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Niacinamide - analogs & derivatives</topic><topic>Niacinamide - pharmacology</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Pathology</topic><topic>Tumor Microenvironment - drug effects</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdelghany, Lina</creatorcontrib><creatorcontrib>Zhang, Xu</creatorcontrib><creatorcontrib>Kawabata, Tsuyoshi</creatorcontrib><creatorcontrib>Goto, Shinji</creatorcontrib><creatorcontrib>El-Mahdy, Nageh</creatorcontrib><creatorcontrib>Jingu, Keiichi</creatorcontrib><creatorcontrib>Li, Tao-Sheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Medical oncology (Northwood, London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdelghany, Lina</au><au>Zhang, Xu</au><au>Kawabata, Tsuyoshi</au><au>Goto, Shinji</au><au>El-Mahdy, Nageh</au><au>Jingu, Keiichi</au><au>Li, Tao-Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nicaraven prevents the fast growth of inflamed tumors by an anti-inflammatory mechanism</atitle><jtitle>Medical oncology (Northwood, London, England)</jtitle><stitle>Med Oncol</stitle><addtitle>Med Oncol</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>39</volume><issue>1</issue><spage>7</spage><epage>7</epage><pages>7-7</pages><artnum>7</artnum><issn>1357-0560</issn><eissn>1559-131X</eissn><abstract>Inflammatory microenvironment is known to accelerate the progression of malignant tumors. We investigated the possible anti-inflammatory effect of nicaraven on slowing tumor growth. Tumor-bearing mice randomly received nicaraven injection (50 mg/kg daily, i.p,
n
= 8) or placebo treatment (
n
= 8) for 10 days, and then sacrificed for evaluations. Nicaraven administration effectively inhibited the fast growth of tumor, as a large tumor (> 1.0 g) developed finally in three of the eight mice received placebo treatment. Cytokines/chemokines array indicated that nicaraven reduced the levels of CXCL10 and SDF-1 in the tumor as well as the levels of IL-2 and MIP-2 in serum. Immunofluorescence staining showed that nicaraven significantly reduced the recruitment of macrophages and neutrophils in the tumor. Interestingly, western blot indicated that the expression of CD86, CD206, and NIMP-R14 was especially enhanced in the three large-size tumors, suggesting the potential role of nicaraven in preventing the hyper-inflammatory tumor microenvironment. Moreover, the expression of PARP-1 was downregulated, but the expression of phospho-p38 MAPK, phospho-MKK-3/6, and phospho-MSK-1 was upregulated in the large-size tumors, suggesting the involvement of p38 MAPK pathway in the anti-inflammatory effect of nicaraven. Taken together, our study suggests that nicaraven may effectively prevent the fast growth of inflamed tumors by an anti-inflammatory mechanism.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>34761342</pmid><doi>10.1007/s12032-021-01602-x</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-7653-8873</orcidid></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents - pharmacology Biomarkers, Tumor - metabolism Cytokines - metabolism Hematology Humans Inflammation - metabolism Internal Medicine Macrophages - drug effects Male Medicine Medicine & Public Health Mice Mice, Inbred C57BL Neoplasms - metabolism Neoplasms - pathology Niacinamide - analogs & derivatives Niacinamide - pharmacology Oncology Original Paper Pathology Tumor Microenvironment - drug effects Tumors |
| title | Nicaraven prevents the fast growth of inflamed tumors by an anti-inflammatory mechanism |
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