Anti‐IgE effect of small‐molecule‐compound arctigenin on food allergy in association with a distinct transcriptome profile

Background Excessive production of IgE plays a major role in the pathology of food allergy. In an attempt to identify anti‐IgE natural products, Arctium Lappa was one of the most effective herbs among approximately 300 screened medicinal herbs. However, little is known about its anti‐IgE compounds....

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Veröffentlicht in:	Clinical and experimental allergy 2022-02, Vol.52 (2), p.250-264
Hauptverfasser:	Cao, Mingzhuo, Liu, Changda, Srivastava, Kamal. D., Lin, Adora, Lazarski, Christopher, Wang, Lu, Maskey, Anish, Song, Ying, Chen, Xiaoke, Yang, Nan, Zambrano, Linda, Bushko, Renna, Nowak‐Wegrzyn, Anna, Cox, Amanda, Liu, Zhigang, Huang, Weihua, Dunkin, David, Miao, Mingsan, Li, Xiu‐Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibodies, Anti-Idiotypic anti‐inflammatory Arctigenin Arctium B and T cell regulation Bcl-6 protein Cell cycle Cell division Food allergies Food Hypersensitivity - drug therapy Furans Herbal medicine Histamine Humans Hypothermia IgE inhibition Immunoglobulin E Inflammation Lignans Lymphocytes T Medicinal plants Mice Myeloma Natural products Patients peanut allergy Peanut Hypersensitivity - drug therapy Plant Extracts - chemistry Transcriptome Transcriptomes
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