An efficient and safe MUC1-dendritic cell-derived exosome conjugate vaccine elicits potent cellular and humoral immunity and tumor inhibition in vivo

Antitumor vaccines are a promising strategy for preventing or treating cancers by eliciting antitumor immune responses and inducing protective immunity against specific antigens expressed on tumor cells. Vaccine formulations that enhance the humoral and cellular immune responses of vaccine candidate...

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Veröffentlicht in:	Acta biomaterialia 2022-01, Vol.138, p.491-504
Hauptverfasser:	Zhu, Haomiao, Wang, Kun, Wang, Zhaoyu, Wang, Danyang, Yin, Xiaona, Liu, Yonghui, Yu, Fan, Zhao, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibody response Antigen (tumor-associated) Antigen presentation Antigens Antitumor activity Biocompatibility Cancer Vaccines CD8 antigen CD8-Positive T-Lymphocytes CD80 antigen CD86 antigen Conjugates Costimulator Crosslinking Cytokines Cytotoxicity Dendritic Cells Dendritic cells-derived exosomes Exosomes Glycopeptides Humoral immunity IgG antibody Immune response (cell-mediated) Immune response (humoral) Immunity Immunity, Cellular Immunity, Humoral Immunization Immunoglobulin G Immunology Lymphocytes Lymphocytes T Major histocompatibility complex Mice Mice, Inbred C57BL MUC1 antigen Neoplasms - therapy Toxicity Tumor cells Vaccine adjuvant Vaccine carrier Vaccines Vaccines, Conjugate
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