Extracellular ATP and cAMP signaling promote Piezo2‐dependent mechanical allodynia after trigeminal nerve compression injury

Trigeminal neuralgia (TN) is a type of severe paroxysmal neuropathic pain commonly triggered by mild mechanical stimulation in the orofacial area. Piezo2, a mechanically gated ion channel that mediates tactile allodynia in neuropathic pain, can be potentiated by a cyclic adenosine monophosphate (cAM...

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Veröffentlicht in:	Journal of neurochemistry 2022-02, Vol.160 (3), p.376-391
Hauptverfasser:	Luo, Zhaoke, Liao, Xinyue, Luo, Lili, Fan, Qitong, Zhang, Xiaofen, Guo, Yuefeng, Wang, Feng, Ye, Zucheng, Luo, Daoshu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine monophosphate Adenosine triphosphate Adenosine Triphosphate - metabolism Animals ATP Ca2+ homeostasis Calcium (extracellular) Calcium (intracellular) Calcium influx Calcium ions Calcium Signaling cAMP signaling pathway Compression Cyclic AMP Cyclic AMP - metabolism Extracellular Space - metabolism Gene expression Guanine Nucleotide Exchange Factors - metabolism Hyperalgesia - physiopathology Injuries Ion channels Ion Channels - antagonists & inhibitors Ion Channels - genetics Ionomycin Male mechanical allodynia Mechanical stimuli Mechanotransduction Na+/Ca2+ exchanger Nerve Compression Syndromes - metabolism Nerve Compression Syndromes - physiopathology Neuralgia Neurons Pain Pain perception Pathogenesis Peripheral neuropathy Piezo2 Purine P2 receptors Rats Rats, Sprague-Dawley Receptors Receptors, Purinergic P2 - drug effects RNA, Small Interfering - pharmacology Signal Transduction Signaling Sodium-Calcium Exchanger - antagonists & inhibitors Stimulation Tactile stimuli Trigeminal ganglion Trigeminal nerve Trigeminal Nerve Injuries - metabolism Trigeminal Nerve Injuries - physiopathology Trigeminal Neuralgia
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