Biotinylation-based proximity labelling proteomics: basics, applications and technical considerations

Abstract Recent advances in biotinylation-based proximity labelling (PL) have opened up new avenues for mapping the protein composition of cellular compartments and protein complexes in living cells at high spatiotemporal resolution. In particular, PL combined with mass spectrometry-based proteomics...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 2021-11, Vol.170 (5), p.569-576
Hauptverfasser:	Niinae, Tomoya, Ishihama, Yasushi, Imami, Koshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biotinylation Humans Mass Spectrometry - methods Organelles - metabolism Protein Binding Protein Interaction Maps Proteome - analysis Proteome - metabolism Proteomics - methods Secretome
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