Spatiotemporal distribution of PKCα, Cdc42, and Rac1 before directed cell migration

Cdc42 is a key factor in directed cell migration and accumulates at the leading edge of migrating cells. However, what kind of proteins control Cdc42 and when is unclear. After mechanical wounding, protein kinase C α (PKCα), a conventional PKC isozyme, begins to accumulate at the edges of cells adja...

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Veröffentlicht in:	Biochemical and biophysical research communications 2021-12, Vol.584, p.26-31
Hauptverfasser:	Sasaki, Saori, Takahashi, Ryu, Luo, Yangfeng, Chujo, Kengo, Sera, Toshihiro, Kudo, Susumu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bryostatins - pharmacology Calcium - metabolism Cdc42 cdc42 GTP-Binding Protein - genetics cdc42 GTP-Binding Protein - metabolism Cell migration Cell Movement Cells, Cultured Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Intracellular Space - drug effects Intracellular Space - metabolism Keratinocytes - cytology Keratinocytes - metabolism Microscopy, Fluorescence - methods Protein Kinase C-alpha - genetics Protein Kinase C-alpha - metabolism Protein kinase Cα Rac1 rac1 GTP-Binding Protein - genetics rac1 GTP-Binding Protein - metabolism Rats Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Stress, Mechanical Time-Lapse Imaging - methods
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