Kissing loop-mediated fabrication of RNA nanoparticles and their potential as cellular and in vivo siRNA delivery platforms

We describe an efficient method to condense RNAs into tightly packed RNA nanoparticles (RNPs) for biomedical applications without hydrophobic or cationic agents. We embedded kissing loops and siRNA in the RNAs to constrain the size of RNPs to 100 nm, making them suitable not only for cellular uptake...

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Veröffentlicht in:	Biomaterials science 2021-12, Vol.9 (24), p.8148-8152
Hauptverfasser:	Kim, Kyoung-Ran, Kim, Junghyun, Mao, Chengde, Ahn, Dae-Ro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical materials Cations Cell Line, Tumor In vivo methods and tests Mice Nanoparticles Ribonucleic acid RNA RNA, Small Interfering - genetics Tumors
Online-Zugang:	Volltext
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