Changes in the clinical phenotype and behavior of pediatric luminal Crohn's disease at diagnosis in the last decade
The aims of this study were to describe the trends in the behavior of pediatric CD during the last decade and to describe the seasonal variation of disease presentation. Patients under 18 years old and diagnosed between 2009 and 2019 were included. The clinical, endoscopic, histological, and laborat...
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| Veröffentlicht in: | Digestive and liver disease 2022-03, Vol.54 (3), p.343-351 |
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| creator | Sassine, Samuel Savoie Robichaud, Mathieu Lin, Yi Fan Djani, Lisa Cambron-Asselin, Christine Qaddouri, Marwa Zekhnine, Souhila Grzywacz, Kelly Groleau, Véronique Dirks, Martha Drouin, Éric Halac, Ugur Marchand, Valérie Girard, Chloé Courbette, Olivier Patey, Natalie Dal Soglio, Dorothée Deslandres, Colette Jantchou, Prévost |
| description | The aims of this study were to describe the trends in the behavior of pediatric CD during the last decade and to describe the seasonal variation of disease presentation.
Patients under 18 years old and diagnosed between 2009 and 2019 were included. The clinical, endoscopic, histological, and laboratory data were collected from the medical records. We analyzed the trends of these parameters according to the year and season of diagnosis.
654 patients were included in the study. The number of incident CD cases increased yearly. Patients diagnosed between 2015 and 2019 were younger at diagnosis (OR 2.53, p = 0.02), had more perianal diseases (OR: 2.30, p |
| doi_str_mv | 10.1016/j.dld.2021.09.012 |
| format | Article |
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Patients under 18 years old and diagnosed between 2009 and 2019 were included. The clinical, endoscopic, histological, and laboratory data were collected from the medical records. We analyzed the trends of these parameters according to the year and season of diagnosis.
654 patients were included in the study. The number of incident CD cases increased yearly. Patients diagnosed between 2015 and 2019 were younger at diagnosis (OR 2.53, p = 0.02), had more perianal diseases (OR: 2.30, p < 0.0001) and more granulomas (OR: 1.61, p = 0.003), but fewer eosinophils (OR: 0.35, p < 0.0001) and less chronic lymphoplasmacytic infiltrate (OR: 0.56, p = 0.008) as compared to the 2009–2014 cohort. There was fewer CD diagnosis during winter. Patients diagnosed in the fall had lower PCDAIs, less failure to thrive and less extensive digestive involvement. Colonic disease was significantly more frequent during summer and fall.
The clinical and histological phenotype of CD has changed over time and there are important seasonal trends in the frequency and severity on disease behavior suggesting possible disease triggers.</description><identifier>ISSN: 1590-8658</identifier><identifier>EISSN: 1878-3562</identifier><identifier>DOI: 10.1016/j.dld.2021.09.012</identifier><identifier>PMID: 34756526</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adolescent ; Age of Onset ; Child ; Crohn Disease - complications ; Crohn Disease - epidemiology ; Crohn Disease - pathology ; Crohn's disease ; Disease evolution ; Disease phenotype ; Disease Progression ; Female ; Granuloma - epidemiology ; Granuloma - etiology ; Granuloma - pathology ; Humans ; Incidence ; Male ; Phenotype ; Seasonal trends in disease behavior ; Seasons ; Severity of Illness Index ; Vitamin D insufficiency</subject><ispartof>Digestive and liver disease, 2022-03, Vol.54 (3), p.343-351</ispartof><rights>2021 Elsevier Ltd</rights><rights>Copyright © 2021 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-4a1673204c347058c86b65e2b9adafb2aa9b6265dded3cf70be19fc906cc551a3</citedby><cites>FETCH-LOGICAL-c396t-4a1673204c347058c86b65e2b9adafb2aa9b6265dded3cf70be19fc906cc551a3</cites><orcidid>0000-0002-6175-7547</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.dld.2021.09.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34756526$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sassine, Samuel</creatorcontrib><creatorcontrib>Savoie Robichaud, Mathieu</creatorcontrib><creatorcontrib>Lin, Yi Fan</creatorcontrib><creatorcontrib>Djani, Lisa</creatorcontrib><creatorcontrib>Cambron-Asselin, Christine</creatorcontrib><creatorcontrib>Qaddouri, Marwa</creatorcontrib><creatorcontrib>Zekhnine, Souhila</creatorcontrib><creatorcontrib>Grzywacz, Kelly</creatorcontrib><creatorcontrib>Groleau, Véronique</creatorcontrib><creatorcontrib>Dirks, Martha</creatorcontrib><creatorcontrib>Drouin, Éric</creatorcontrib><creatorcontrib>Halac, Ugur</creatorcontrib><creatorcontrib>Marchand, Valérie</creatorcontrib><creatorcontrib>Girard, Chloé</creatorcontrib><creatorcontrib>Courbette, Olivier</creatorcontrib><creatorcontrib>Patey, Natalie</creatorcontrib><creatorcontrib>Dal Soglio, Dorothée</creatorcontrib><creatorcontrib>Deslandres, Colette</creatorcontrib><creatorcontrib>Jantchou, Prévost</creatorcontrib><title>Changes in the clinical phenotype and behavior of pediatric luminal Crohn's disease at diagnosis in the last decade</title><title>Digestive and liver disease</title><addtitle>Dig Liver Dis</addtitle><description>The aims of this study were to describe the trends in the behavior of pediatric CD during the last decade and to describe the seasonal variation of disease presentation.
Patients under 18 years old and diagnosed between 2009 and 2019 were included. The clinical, endoscopic, histological, and laboratory data were collected from the medical records. We analyzed the trends of these parameters according to the year and season of diagnosis.
654 patients were included in the study. The number of incident CD cases increased yearly. Patients diagnosed between 2015 and 2019 were younger at diagnosis (OR 2.53, p = 0.02), had more perianal diseases (OR: 2.30, p < 0.0001) and more granulomas (OR: 1.61, p = 0.003), but fewer eosinophils (OR: 0.35, p < 0.0001) and less chronic lymphoplasmacytic infiltrate (OR: 0.56, p = 0.008) as compared to the 2009–2014 cohort. There was fewer CD diagnosis during winter. Patients diagnosed in the fall had lower PCDAIs, less failure to thrive and less extensive digestive involvement. Colonic disease was significantly more frequent during summer and fall.
The clinical and histological phenotype of CD has changed over time and there are important seasonal trends in the frequency and severity on disease behavior suggesting possible disease triggers.</description><subject>Adolescent</subject><subject>Age of Onset</subject><subject>Child</subject><subject>Crohn Disease - complications</subject><subject>Crohn Disease - epidemiology</subject><subject>Crohn Disease - pathology</subject><subject>Crohn's disease</subject><subject>Disease evolution</subject><subject>Disease phenotype</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Granuloma - epidemiology</subject><subject>Granuloma - etiology</subject><subject>Granuloma - pathology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Phenotype</subject><subject>Seasonal trends in disease behavior</subject><subject>Seasons</subject><subject>Severity of Illness Index</subject><subject>Vitamin D insufficiency</subject><issn>1590-8658</issn><issn>1878-3562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFq3DAQhkVJaDZpH6CXoltzsSPJK9mip7I0TSHQS3IWY2kca_FKruRdyNtXYbd7zEmD-P6fmY-QL5zVnHF1t63d5GrBBK-ZrhkXH8iKd21XNVKJizJLzapOye6KXOe8ZQVUkn0kV826lUoKtSJ5M0J4wUx9oMuI1E4-eAsTnUcMcXmdkUJwtMcRDj4mGgc6o_OwJG_ptN_5UNhNimP4lqnzGSGXxFJGeAkx-3PxBLn8ogWHn8jlAFPGz6f3hjzf_3zaPFSPf3793vx4rGyj1VKtgau2EWxty7pMdrZTvZIoeg0Ohl4A6F4JJZ1D19ihZT1yPVjNlLVScmhuyO2xd07x7x7zYnY-W5wmCBj32QipVZHGm7ag_IjaFHNOOJg5-R2kV8OZeXNttqa4Nm-uDdOmxErm66l-3-_QnRP_5Rbg-xHAcuTBYzLZegy2-EtoF-Oif6f-HyRBkDk</recordid><startdate>202203</startdate><enddate>202203</enddate><creator>Sassine, Samuel</creator><creator>Savoie Robichaud, Mathieu</creator><creator>Lin, Yi Fan</creator><creator>Djani, Lisa</creator><creator>Cambron-Asselin, Christine</creator><creator>Qaddouri, Marwa</creator><creator>Zekhnine, Souhila</creator><creator>Grzywacz, Kelly</creator><creator>Groleau, Véronique</creator><creator>Dirks, Martha</creator><creator>Drouin, Éric</creator><creator>Halac, Ugur</creator><creator>Marchand, Valérie</creator><creator>Girard, Chloé</creator><creator>Courbette, Olivier</creator><creator>Patey, Natalie</creator><creator>Dal Soglio, Dorothée</creator><creator>Deslandres, Colette</creator><creator>Jantchou, Prévost</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6175-7547</orcidid></search><sort><creationdate>202203</creationdate><title>Changes in the clinical phenotype and behavior of pediatric luminal Crohn's disease at diagnosis in the last decade</title><author>Sassine, Samuel ; Savoie Robichaud, Mathieu ; Lin, Yi Fan ; Djani, Lisa ; Cambron-Asselin, Christine ; Qaddouri, Marwa ; Zekhnine, Souhila ; Grzywacz, Kelly ; Groleau, Véronique ; Dirks, Martha ; Drouin, Éric ; Halac, Ugur ; Marchand, Valérie ; Girard, Chloé ; Courbette, Olivier ; Patey, Natalie ; Dal Soglio, Dorothée ; Deslandres, Colette ; Jantchou, Prévost</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-4a1673204c347058c86b65e2b9adafb2aa9b6265dded3cf70be19fc906cc551a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adolescent</topic><topic>Age of Onset</topic><topic>Child</topic><topic>Crohn Disease - complications</topic><topic>Crohn Disease - epidemiology</topic><topic>Crohn Disease - pathology</topic><topic>Crohn's disease</topic><topic>Disease evolution</topic><topic>Disease phenotype</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Granuloma - epidemiology</topic><topic>Granuloma - etiology</topic><topic>Granuloma - pathology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Phenotype</topic><topic>Seasonal trends in disease behavior</topic><topic>Seasons</topic><topic>Severity of Illness Index</topic><topic>Vitamin D insufficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sassine, Samuel</creatorcontrib><creatorcontrib>Savoie Robichaud, Mathieu</creatorcontrib><creatorcontrib>Lin, Yi Fan</creatorcontrib><creatorcontrib>Djani, Lisa</creatorcontrib><creatorcontrib>Cambron-Asselin, Christine</creatorcontrib><creatorcontrib>Qaddouri, Marwa</creatorcontrib><creatorcontrib>Zekhnine, Souhila</creatorcontrib><creatorcontrib>Grzywacz, Kelly</creatorcontrib><creatorcontrib>Groleau, Véronique</creatorcontrib><creatorcontrib>Dirks, Martha</creatorcontrib><creatorcontrib>Drouin, Éric</creatorcontrib><creatorcontrib>Halac, Ugur</creatorcontrib><creatorcontrib>Marchand, Valérie</creatorcontrib><creatorcontrib>Girard, Chloé</creatorcontrib><creatorcontrib>Courbette, Olivier</creatorcontrib><creatorcontrib>Patey, Natalie</creatorcontrib><creatorcontrib>Dal Soglio, Dorothée</creatorcontrib><creatorcontrib>Deslandres, Colette</creatorcontrib><creatorcontrib>Jantchou, Prévost</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive and liver disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sassine, Samuel</au><au>Savoie Robichaud, Mathieu</au><au>Lin, Yi Fan</au><au>Djani, Lisa</au><au>Cambron-Asselin, Christine</au><au>Qaddouri, Marwa</au><au>Zekhnine, Souhila</au><au>Grzywacz, Kelly</au><au>Groleau, Véronique</au><au>Dirks, Martha</au><au>Drouin, Éric</au><au>Halac, Ugur</au><au>Marchand, Valérie</au><au>Girard, Chloé</au><au>Courbette, Olivier</au><au>Patey, Natalie</au><au>Dal Soglio, Dorothée</au><au>Deslandres, Colette</au><au>Jantchou, Prévost</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in the clinical phenotype and behavior of pediatric luminal Crohn's disease at diagnosis in the last decade</atitle><jtitle>Digestive and liver disease</jtitle><addtitle>Dig Liver Dis</addtitle><date>2022-03</date><risdate>2022</risdate><volume>54</volume><issue>3</issue><spage>343</spage><epage>351</epage><pages>343-351</pages><issn>1590-8658</issn><eissn>1878-3562</eissn><abstract>The aims of this study were to describe the trends in the behavior of pediatric CD during the last decade and to describe the seasonal variation of disease presentation.
Patients under 18 years old and diagnosed between 2009 and 2019 were included. The clinical, endoscopic, histological, and laboratory data were collected from the medical records. We analyzed the trends of these parameters according to the year and season of diagnosis.
654 patients were included in the study. The number of incident CD cases increased yearly. Patients diagnosed between 2015 and 2019 were younger at diagnosis (OR 2.53, p = 0.02), had more perianal diseases (OR: 2.30, p < 0.0001) and more granulomas (OR: 1.61, p = 0.003), but fewer eosinophils (OR: 0.35, p < 0.0001) and less chronic lymphoplasmacytic infiltrate (OR: 0.56, p = 0.008) as compared to the 2009–2014 cohort. There was fewer CD diagnosis during winter. Patients diagnosed in the fall had lower PCDAIs, less failure to thrive and less extensive digestive involvement. Colonic disease was significantly more frequent during summer and fall.
The clinical and histological phenotype of CD has changed over time and there are important seasonal trends in the frequency and severity on disease behavior suggesting possible disease triggers.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>34756526</pmid><doi>10.1016/j.dld.2021.09.012</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6175-7547</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Digestive and liver disease, 2022-03, Vol.54 (3), p.343-351 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Age of Onset Child Crohn Disease - complications Crohn Disease - epidemiology Crohn Disease - pathology Crohn's disease Disease evolution Disease phenotype Disease Progression Female Granuloma - epidemiology Granuloma - etiology Granuloma - pathology Humans Incidence Male Phenotype Seasonal trends in disease behavior Seasons Severity of Illness Index Vitamin D insufficiency |
| title | Changes in the clinical phenotype and behavior of pediatric luminal Crohn's disease at diagnosis in the last decade |
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