Cation‐Free siRNA Micelles as Effective Drug Delivery Platform and Potent RNAi Nanomedicines for Glioblastoma Therapy

Nanoparticle‐based small interfering RNA (siRNA) therapy shows great promise for glioblastoma (GBM). However, charge associated toxicity and limited blood–brain‐barrier (BBB) penetration remain significant challenges for siRNA delivery for GBM therapy. Herein, novel cation‐free siRNA micelles, prepa...

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Veröffentlicht in:	Advanced materials (Weinheim) 2021-11, Vol.33 (45), p.e2104779-n/a
Hauptverfasser:	Jiang, Tong, Qiao, Yonghan, Ruan, Weimin, Zhang, Dongya, Yang, Qingshan, Wang, Guoying, Chen, Qunzhi, Zhu, Fengping, Yin, Jinlong, Zou, Yan, Qian, Rongjun, Zheng, Meng, Shi, Bingyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins - chemistry Animals Block copolymers Blood circulation Blood-Brain Barrier - metabolism Carbocyanines - chemistry Cations Cations - chemistry cation‐free Cell Line, Tumor Drug Carriers - chemistry Gene expression glioblastoma Glioblastoma - drug therapy Glioblastoma - pathology Humans Mice micelle Micelles Nanomedicine Nanoparticles Nanoparticles - chemistry Penetration Polyisopropyl acrylamide Ribonucleic acid RNA RNA Interference RNA, Small Interfering - chemistry RNA, Small Interfering - pharmacokinetics RNA, Small Interfering - therapeutic use siRNA spherical nucleic acid STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Temozolomide - therapeutic use Therapy Tissue Distribution Toxicity Transducers Transplantation, Heterologous Xenotransplantation
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