Semaporin3A inhibitor ameliorates renal fibrosis through the regulation of JNK signaling

Renal fibrosis is the common pathological pathway in progressive renal diseases. In the present study, we analyzed the roles of semaphorin 3 A (SEMA3A) on renal fibrosis and the effect of SEMA3A inhibitor (SEMA3A-I) using a unilateral ureteral obstruction (UUO) mouse model. Expression of SEMA3A in t...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2021-12, Vol.321 (6), p.F740-F756
Hauptverfasser:	Sang, Yizhen, Tsuji, Kenji, Fukushima, Kazuhiko, Takahashi, Kensaku, Kitamura, Shinji, Wada, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Cell activation Collagen (type I) Disease Models, Animal Epithelial cells Female Fibroblasts Fibrosis Glucosaminidase Humans JNK Mitogen-Activated Protein Kinases - metabolism Kidney - drug effects Kidney - enzymology Kidney - metabolism Kidney Diseases - enzymology Kidney Diseases - etiology Kidney Diseases - pathology Kidney Diseases - prevention & control Kidneys Kinases Male Mice Mice, Inbred C57BL Middle Aged Neuropilin NIH 3T3 Cells Oxidation Renal Agents - pharmacology Semaphorin-3A - antagonists & inhibitors Semaphorin-3A - metabolism Semaphorins Signal Transduction Tenascin Tenascin C Transforming growth factor-b1 Ureteral Obstruction - complications
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