Neuroimaging Features of Intracranial Hypertension in Pediatric Patients With New-Onset Idiopathic Seizures, a Comparison With Patients with Confirmed Diagnosis of Idiopathic Intracranial Hypertension: A Preliminary Study
Seizures have been reported in association with idiopathic intracranial hypertension in pediatric patients. Magnetic resonance imaging (MRI) signs of intracranial hypertension have not been investigated before in pediatric patients with new-onset idiopathic seizures. MRI scans of 182 pediatric patie...
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| Veröffentlicht in: | Journal of child neurology 2021-10, Vol.36 (12), p.1103-1110 |
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| creator | Kamali, Arash Aein, Azin Naderi, Niyousha Choi, Sally J. Doyle, Nathan Butler, Ian J. Huisman, Thierry A.G.M. Bonfante, Eliana E. Sheikh-Bahaei, Nasim Khanpara, Shekhar Patel, Rajan P. Riascos, Roy F. Zhang, Xu Tang, Rosa A. Radmanesh, Alireza |
| description | Seizures have been reported in association with idiopathic intracranial hypertension in pediatric patients. Magnetic resonance imaging (MRI) signs of intracranial hypertension have not been investigated before in pediatric patients with new-onset idiopathic seizures. MRI scans of 182 pediatric patients were retrospectively analyzed for imaging findings of intracranial hypertension, including 46 patients with new-onset idiopathic seizures and elevated cerebrospinal fluid opening pressure, 40 patients with new-onset idiopathic seizures and normal opening pressure, 56 patients with confirmed idiopathic intracranial hypertension, and 40 age- and sex-matched controls. The optic nerve sheath diameter is significantly larger in the group with new-onset idiopathic seizures and elevated opening pressure (mean diameter of 6.02 ± 0.45 mm) compared to patients with new-onset idiopathic seizures and normal opening pressure (mean diameter of 5.24 ± 0.50 mm) (P value |
| doi_str_mv | 10.1177/08830738211045234 |
| format | Article |
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Conclusion
A cutoff value of 6.0 mm for optic nerve sheath dilation may be used as a screening imaging marker to suspect elevated opening pressure with specificity of 88% in pediatric patients with new-onset idiopathic seizures.</description><identifier>ISSN: 0883-0738</identifier><identifier>EISSN: 1708-8283</identifier><identifier>DOI: 10.1177/08830738211045234</identifier><identifier>PMID: 34747259</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adolescent ; Brain - diagnostic imaging ; Brain - physiopathology ; Child ; Child, Preschool ; Cohort Studies ; Female ; Humans ; Infant ; Intracranial Hypertension - complications ; Intracranial Hypertension - diagnostic imaging ; Intracranial Hypertension - physiopathology ; Magnetic Resonance Imaging - methods ; Male ; Neuroimaging - methods ; Reproducibility of Results ; Retrospective Studies ; Seizures - complications ; Seizures - physiopathology ; Sensitivity and Specificity</subject><ispartof>Journal of child neurology, 2021-10, Vol.36 (12), p.1103-1110</ispartof><rights>The Author(s) 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-1e29cf1a4c75f4e185f47ab9d04ada6a935ff3dc9e37fe3688c63c7ccede93e3</citedby><cites>FETCH-LOGICAL-c340t-1e29cf1a4c75f4e185f47ab9d04ada6a935ff3dc9e37fe3688c63c7ccede93e3</cites><orcidid>0000-0002-0891-1541 ; 0000-0001-7498-3247</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/08830738211045234$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/08830738211045234$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34747259$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamali, Arash</creatorcontrib><creatorcontrib>Aein, Azin</creatorcontrib><creatorcontrib>Naderi, Niyousha</creatorcontrib><creatorcontrib>Choi, Sally J.</creatorcontrib><creatorcontrib>Doyle, Nathan</creatorcontrib><creatorcontrib>Butler, Ian J.</creatorcontrib><creatorcontrib>Huisman, Thierry A.G.M.</creatorcontrib><creatorcontrib>Bonfante, Eliana E.</creatorcontrib><creatorcontrib>Sheikh-Bahaei, Nasim</creatorcontrib><creatorcontrib>Khanpara, Shekhar</creatorcontrib><creatorcontrib>Patel, Rajan P.</creatorcontrib><creatorcontrib>Riascos, Roy F.</creatorcontrib><creatorcontrib>Zhang, Xu</creatorcontrib><creatorcontrib>Tang, Rosa A.</creatorcontrib><creatorcontrib>Radmanesh, Alireza</creatorcontrib><title>Neuroimaging Features of Intracranial Hypertension in Pediatric Patients With New-Onset Idiopathic Seizures, a Comparison With Patients with Confirmed Diagnosis of Idiopathic Intracranial Hypertension: A Preliminary Study</title><title>Journal of child neurology</title><addtitle>J Child Neurol</addtitle><description>Seizures have been reported in association with idiopathic intracranial hypertension in pediatric patients. Magnetic resonance imaging (MRI) signs of intracranial hypertension have not been investigated before in pediatric patients with new-onset idiopathic seizures. MRI scans of 182 pediatric patients were retrospectively analyzed for imaging findings of intracranial hypertension, including 46 patients with new-onset idiopathic seizures and elevated cerebrospinal fluid opening pressure, 40 patients with new-onset idiopathic seizures and normal opening pressure, 56 patients with confirmed idiopathic intracranial hypertension, and 40 age- and sex-matched controls. The optic nerve sheath diameter is significantly larger in the group with new-onset idiopathic seizures and elevated opening pressure (mean diameter of 6.02 ± 0.45 mm) compared to patients with new-onset idiopathic seizures and normal opening pressure (mean diameter of 5.24 ± 0.50 mm) (P value <.001). The cutoff value of 6.0 mm for optic nerve sheath diameter showed 63% sensitivity and 88% specificity to differentiate pediatric patients with seizures and elevated opening pressure from those with seizures and normal opening pressure.
Conclusion
A cutoff value of 6.0 mm for optic nerve sheath dilation may be used as a screening imaging marker to suspect elevated opening pressure with specificity of 88% in pediatric patients with new-onset idiopathic seizures.</description><subject>Adolescent</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - physiopathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Intracranial Hypertension - complications</subject><subject>Intracranial Hypertension - diagnostic imaging</subject><subject>Intracranial Hypertension - physiopathology</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Neuroimaging - methods</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Seizures - complications</subject><subject>Seizures - physiopathology</subject><subject>Sensitivity and Specificity</subject><issn>0883-0738</issn><issn>1708-8283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAURS0EotPCB7BBXrIgxY6dscOumlI6UtWO1Eoso1fnZeoqsYPtqBr-lX-pw5SyQLCxZfneo_fuJeQdZ8ecK_WJaS2YErrknMmqFPIFWXDFdKFLLV6SxfxfzIIDchjjPWNMVzV7TQ6EVFKVVb0gPy9xCt4OsLVuS88Q0hQwUt_RtUsBTABnoafnuxFDQhetd9Q6usHWQgrW0A0kiy5F-s2mO3qJD8WVi5jourV-hHSXJddof8zUjxToyg8jBBsz5pfh2f4wv1bedTYM2NJTC1vno92P8of1z6k-0xO6CdjbwToIO3qdpnb3hrzqoI_49uk-IjdnX25W58XF1df16uSiMEKyVHAsa9NxkEZVnUSu86ngtm6ZhBaWUIuq60RrahSqQ7HU2iyFUcZgi7VAcUQ-7LFj8N8njKkZbDTY9-DQT7HJSVe8LMVSZinfS03wMQbsmjHk9MOu4ayZS23-KjV73j_hp9uczbPjd4tZcLwXRNhic--n4PK2_yE-ArVXsIA</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Kamali, Arash</creator><creator>Aein, Azin</creator><creator>Naderi, Niyousha</creator><creator>Choi, Sally J.</creator><creator>Doyle, Nathan</creator><creator>Butler, Ian J.</creator><creator>Huisman, Thierry A.G.M.</creator><creator>Bonfante, Eliana E.</creator><creator>Sheikh-Bahaei, Nasim</creator><creator>Khanpara, Shekhar</creator><creator>Patel, Rajan P.</creator><creator>Riascos, Roy F.</creator><creator>Zhang, Xu</creator><creator>Tang, Rosa A.</creator><creator>Radmanesh, Alireza</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0891-1541</orcidid><orcidid>https://orcid.org/0000-0001-7498-3247</orcidid></search><sort><creationdate>202110</creationdate><title>Neuroimaging Features of Intracranial Hypertension in Pediatric Patients With New-Onset Idiopathic Seizures, a Comparison With Patients with Confirmed Diagnosis of Idiopathic Intracranial Hypertension: A Preliminary Study</title><author>Kamali, Arash ; Aein, Azin ; Naderi, Niyousha ; Choi, Sally J. ; Doyle, Nathan ; Butler, Ian J. ; Huisman, Thierry A.G.M. ; Bonfante, Eliana E. ; Sheikh-Bahaei, Nasim ; Khanpara, Shekhar ; Patel, Rajan P. ; Riascos, Roy F. ; Zhang, Xu ; Tang, Rosa A. ; Radmanesh, Alireza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-1e29cf1a4c75f4e185f47ab9d04ada6a935ff3dc9e37fe3688c63c7ccede93e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - physiopathology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Intracranial Hypertension - complications</topic><topic>Intracranial Hypertension - diagnostic imaging</topic><topic>Intracranial Hypertension - physiopathology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Neuroimaging - methods</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Seizures - complications</topic><topic>Seizures - physiopathology</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamali, Arash</creatorcontrib><creatorcontrib>Aein, Azin</creatorcontrib><creatorcontrib>Naderi, Niyousha</creatorcontrib><creatorcontrib>Choi, Sally J.</creatorcontrib><creatorcontrib>Doyle, Nathan</creatorcontrib><creatorcontrib>Butler, Ian J.</creatorcontrib><creatorcontrib>Huisman, Thierry A.G.M.</creatorcontrib><creatorcontrib>Bonfante, Eliana E.</creatorcontrib><creatorcontrib>Sheikh-Bahaei, Nasim</creatorcontrib><creatorcontrib>Khanpara, Shekhar</creatorcontrib><creatorcontrib>Patel, Rajan P.</creatorcontrib><creatorcontrib>Riascos, Roy F.</creatorcontrib><creatorcontrib>Zhang, Xu</creatorcontrib><creatorcontrib>Tang, Rosa A.</creatorcontrib><creatorcontrib>Radmanesh, Alireza</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of child neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamali, Arash</au><au>Aein, Azin</au><au>Naderi, Niyousha</au><au>Choi, Sally J.</au><au>Doyle, Nathan</au><au>Butler, Ian J.</au><au>Huisman, Thierry A.G.M.</au><au>Bonfante, Eliana E.</au><au>Sheikh-Bahaei, Nasim</au><au>Khanpara, Shekhar</au><au>Patel, Rajan P.</au><au>Riascos, Roy F.</au><au>Zhang, Xu</au><au>Tang, Rosa A.</au><au>Radmanesh, Alireza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroimaging Features of Intracranial Hypertension in Pediatric Patients With New-Onset Idiopathic Seizures, a Comparison With Patients with Confirmed Diagnosis of Idiopathic Intracranial Hypertension: A Preliminary Study</atitle><jtitle>Journal of child neurology</jtitle><addtitle>J Child Neurol</addtitle><date>2021-10</date><risdate>2021</risdate><volume>36</volume><issue>12</issue><spage>1103</spage><epage>1110</epage><pages>1103-1110</pages><issn>0883-0738</issn><eissn>1708-8283</eissn><abstract>Seizures have been reported in association with idiopathic intracranial hypertension in pediatric patients. Magnetic resonance imaging (MRI) signs of intracranial hypertension have not been investigated before in pediatric patients with new-onset idiopathic seizures. MRI scans of 182 pediatric patients were retrospectively analyzed for imaging findings of intracranial hypertension, including 46 patients with new-onset idiopathic seizures and elevated cerebrospinal fluid opening pressure, 40 patients with new-onset idiopathic seizures and normal opening pressure, 56 patients with confirmed idiopathic intracranial hypertension, and 40 age- and sex-matched controls. The optic nerve sheath diameter is significantly larger in the group with new-onset idiopathic seizures and elevated opening pressure (mean diameter of 6.02 ± 0.45 mm) compared to patients with new-onset idiopathic seizures and normal opening pressure (mean diameter of 5.24 ± 0.50 mm) (P value <.001). The cutoff value of 6.0 mm for optic nerve sheath diameter showed 63% sensitivity and 88% specificity to differentiate pediatric patients with seizures and elevated opening pressure from those with seizures and normal opening pressure.
Conclusion
A cutoff value of 6.0 mm for optic nerve sheath dilation may be used as a screening imaging marker to suspect elevated opening pressure with specificity of 88% in pediatric patients with new-onset idiopathic seizures.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>34747259</pmid><doi>10.1177/08830738211045234</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0891-1541</orcidid><orcidid>https://orcid.org/0000-0001-7498-3247</orcidid></addata></record> |
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| subjects | Adolescent Brain - diagnostic imaging Brain - physiopathology Child Child, Preschool Cohort Studies Female Humans Infant Intracranial Hypertension - complications Intracranial Hypertension - diagnostic imaging Intracranial Hypertension - physiopathology Magnetic Resonance Imaging - methods Male Neuroimaging - methods Reproducibility of Results Retrospective Studies Seizures - complications Seizures - physiopathology Sensitivity and Specificity |
| title | Neuroimaging Features of Intracranial Hypertension in Pediatric Patients With New-Onset Idiopathic Seizures, a Comparison With Patients with Confirmed Diagnosis of Idiopathic Intracranial Hypertension: A Preliminary Study |
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