PEDF is an endogenous inhibitor of VEGF-R2 angiogenesis signaling in endothelial cells

Pigment epithelium derived factor (PEDF), an endogenous inhibitor of angiogenesis, targets the growth of aberrant blood vessels in many tissues, including the eye. In this study we show that PEDF prevented early mitogenic signals of vascular endothelial growth factor (VEGF-A) in primate retinal endo...

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Veröffentlicht in:	Experimental eye research 2021-12, Vol.213, p.108828-108828, Article 108828
Hauptverfasser:	Zhang, Mingliang, Tombran-Tink, Joyce, Yang, Songyang, Zhang, Xiaomin, Li, Xiaorong, Barnstable, Colin J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inhibitors - physiology Animals Blood Vessels - drug effects Blotting, Western Cell Movement - drug effects Cell Proliferation - drug effects Endothelial Cells - drug effects Endothelial Cells - metabolism Enzyme-Linked Immunosorbent Assay Eye Proteins - physiology Human Umbilical Vein Endothelial Cells - drug effects Humans Nerve Growth Factors - physiology PEDF Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Primates Real-Time Polymerase Chain Reaction Receptor phosphorylation Retinal Vessels - cytology Serpins - physiology Signal Transduction - physiology Tyrosine - metabolism Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors VEGF-A VEGF-R2
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