A Dual Promoter System to Monitor IFN-γ Signaling in vivo at Single-cell Resolution

IFN-γ secreted from immune cells exerts pleiotropic effects on tumor cells, including induction of immune checkpoint and antigen presentation, growth inhibition, and apoptosis induction. We combined a dual promoter system with an IFN-γ signaling responsive promoter to generate a reporter named the i...

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Veröffentlicht in:	Cell Structure and Function 2021, Vol.46(2), pp.103-111
Hauptverfasser:	Tanaka, Taisei, Konishi, Yoshinobu, Ichise, Hiroshi, Tsukiji, Shinya, Matsuda, Michiyuki, Terai, Kenta
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen presentation Apoptosis Bioluminescence Biosensors Cancer Cell cycle Cell growth dual promoter system Immune checkpoint in vivo imaging interferon-gamma Interferon-gamma - genetics Kinases Lasers Melanoma Plasmids Promoter Regions, Genetic - genetics RNA, Messenger Signal Transduction Transcription, Genetic Transplantation Tumor cells tumor microenvironment Tumors γ-Interferon
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