Surgical indication of pulmonary metastasis arising from osteosarcoma or soft tissue sarcoma
Objectives Metastasectomy is often the local treatment for pulmonary metastases arising from osteosarcoma or soft tissue sarcoma. However, there have been few investigations on the outcomes of patients who undergo this procedure. In this study, we identified prognostic factors in patients with pulmo...
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| Veröffentlicht in: | General thoracic and cardiovascular surgery 2022-03, Vol.70 (3), p.273-279 |
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| creator | Omura, Akiisa Kimura, Toru Tanaka, Ryo Hiroshima, Takashi Maniwa, Tomohiro Takenaka, Satoshi Naka, Norifumi Okami, Jiro |
| description | Objectives
Metastasectomy is often the local treatment for pulmonary metastases arising from osteosarcoma or soft tissue sarcoma. However, there have been few investigations on the outcomes of patients who undergo this procedure. In this study, we identified prognostic factors in patients with pulmonary metastases arising from osteosarcoma and soft tissue sarcoma to determine more appropriate eligibility criteria for metastasectomy.
Methods
We retrospectively examined 37 patients who underwent metastasectomy of pulmonary nodules arising from osteosarcomas or soft tissue sarcomas at our institute between 2005 and 2020. Overall and recurrence-free survival intervals were determined using univariate and multivariate analyses.
Results
A tumor doubling time > 1 month and a primary tumor histological type of osteosarcoma were independent predictors of longer overall survival on multivariate analysis (hazard ratios: 3.618 and 2.979,
p
= 0.00986 and 0.0373, respectively). Moreover, a > 1-month tumor doubling time and > 10-cm diameter of the primary tumor were independent predictors of longer recurrence-free survival (hazard ratios: 3.293 and 2.67,
p
= 0.0121 and 0.0134, respectively). Patients who underwent repeat pulmonary metastasectomy after complete resection of sarcoma-derived pulmonary metastases had significantly longer overall survival than those who did not (median: 5.91 years vs. 0.81 years,
p
|
| doi_str_mv | 10.1007/s11748-021-01726-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2595111636</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2918742734</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-69d22fc611a1891d0754fddcd00211b4f2ee9e3504feeed43006d2da4a708ab83</originalsourceid><addsrcrecordid>eNp9kE1LJDEQhoO4-DH6BzxIwIuXdlNJOuk-iugqCB7WvS2ETCcZIt2dMdUN-u_NOrMKHoRAheSpN5WHkBNgF8CY_okAWjYV41Ax0FxVLzvkABolKqVB7H7sWb1PDhGfGKtVA_Ue2RdSSyEYPyB_f895FTvb0zi6UqeYRpoCXc_9kEabX-ngJ4tlRaQ2R4zjioacBppw8glt7tJgacoUU5joFBFnT7fHR-RHsD36421dkD83149Xt9X9w6-7q8v7qpOqnirVOs5DpwAsNC04pmsZnOscK1-DpQzc-9aLmsngvXdSMKYcd1ZazRq7bMSCnG9y1zk9zx4nM0TsfN_b0acZDa_bGgCUUAU9-4I-pTmPZTrDW2i05FrIQvEN1eWEmH0w6xyHYsMAM__cm417UwY07-7NS2k63UbPy8G7j5b_sgsgNgCWq3Hl8-fb38S-AVnZkNQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2918742734</pqid></control><display><type>article</type><title>Surgical indication of pulmonary metastasis arising from osteosarcoma or soft tissue sarcoma</title><source>MEDLINE</source><source>ProQuest Central (Alumni Edition)</source><source>ProQuest Central UK/Ireland</source><source>SpringerLink Journals - AutoHoldings</source><source>ProQuest Central</source><creator>Omura, Akiisa ; Kimura, Toru ; Tanaka, Ryo ; Hiroshima, Takashi ; Maniwa, Tomohiro ; Takenaka, Satoshi ; Naka, Norifumi ; Okami, Jiro</creator><creatorcontrib>Omura, Akiisa ; Kimura, Toru ; Tanaka, Ryo ; Hiroshima, Takashi ; Maniwa, Tomohiro ; Takenaka, Satoshi ; Naka, Norifumi ; Okami, Jiro</creatorcontrib><description>Objectives
Metastasectomy is often the local treatment for pulmonary metastases arising from osteosarcoma or soft tissue sarcoma. However, there have been few investigations on the outcomes of patients who undergo this procedure. In this study, we identified prognostic factors in patients with pulmonary metastases arising from osteosarcoma and soft tissue sarcoma to determine more appropriate eligibility criteria for metastasectomy.
Methods
We retrospectively examined 37 patients who underwent metastasectomy of pulmonary nodules arising from osteosarcomas or soft tissue sarcomas at our institute between 2005 and 2020. Overall and recurrence-free survival intervals were determined using univariate and multivariate analyses.
Results
A tumor doubling time > 1 month and a primary tumor histological type of osteosarcoma were independent predictors of longer overall survival on multivariate analysis (hazard ratios: 3.618 and 2.979,
p
= 0.00986 and 0.0373, respectively). Moreover, a > 1-month tumor doubling time and > 10-cm diameter of the primary tumor were independent predictors of longer recurrence-free survival (hazard ratios: 3.293 and 2.67,
p
= 0.0121 and 0.0134, respectively). Patients who underwent repeat pulmonary metastasectomy after complete resection of sarcoma-derived pulmonary metastases had significantly longer overall survival than those who did not (median: 5.91 years vs. 0.81 years,
p
< 0.0001).
Conclusions
Tumor doubling time is a significant predictor of clinical outcomes in patients who undergo resection of pulmonary metastases originating from sarcomas. The surgical indication for this procedure should be decided carefully, particularly for patients with metastatic lesion doubling times ≤ 1 month.</description><identifier>ISSN: 1863-6705</identifier><identifier>EISSN: 1863-6713</identifier><identifier>DOI: 10.1007/s11748-021-01726-x</identifier><identifier>PMID: 34743302</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Bone cancer ; Bone Neoplasms - surgery ; Cardiac Surgery ; Cardiology ; Chemotherapy ; Histology ; Humans ; Lung cancer ; Lung Neoplasms - pathology ; Medical prognosis ; Medicine ; Medicine & Public Health ; Metastasectomy - methods ; Metastasis ; Multivariate analysis ; Original Article ; Osteosarcoma - surgery ; Ostomy ; Patients ; Prognosis ; Retrospective Studies ; Sarcoma ; Sarcoma - surgery ; Surgical Oncology ; Surgical outcomes ; Survival Rate ; Thoracic Surgery</subject><ispartof>General thoracic and cardiovascular surgery, 2022-03, Vol.70 (3), p.273-279</ispartof><rights>The Japanese Association for Thoracic Surgery 2021</rights><rights>2021. The Japanese Association for Thoracic Surgery.</rights><rights>The Japanese Association for Thoracic Surgery 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-69d22fc611a1891d0754fddcd00211b4f2ee9e3504feeed43006d2da4a708ab83</citedby><cites>FETCH-LOGICAL-c465t-69d22fc611a1891d0754fddcd00211b4f2ee9e3504feeed43006d2da4a708ab83</cites><orcidid>0000-0003-4504-232X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11748-021-01726-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918742734?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21387,21388,27923,27924,33529,33530,33743,33744,41487,42556,43658,43804,51318,64384,64386,64388,72240</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34743302$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Omura, Akiisa</creatorcontrib><creatorcontrib>Kimura, Toru</creatorcontrib><creatorcontrib>Tanaka, Ryo</creatorcontrib><creatorcontrib>Hiroshima, Takashi</creatorcontrib><creatorcontrib>Maniwa, Tomohiro</creatorcontrib><creatorcontrib>Takenaka, Satoshi</creatorcontrib><creatorcontrib>Naka, Norifumi</creatorcontrib><creatorcontrib>Okami, Jiro</creatorcontrib><title>Surgical indication of pulmonary metastasis arising from osteosarcoma or soft tissue sarcoma</title><title>General thoracic and cardiovascular surgery</title><addtitle>Gen Thorac Cardiovasc Surg</addtitle><addtitle>Gen Thorac Cardiovasc Surg</addtitle><description>Objectives
Metastasectomy is often the local treatment for pulmonary metastases arising from osteosarcoma or soft tissue sarcoma. However, there have been few investigations on the outcomes of patients who undergo this procedure. In this study, we identified prognostic factors in patients with pulmonary metastases arising from osteosarcoma and soft tissue sarcoma to determine more appropriate eligibility criteria for metastasectomy.
Methods
We retrospectively examined 37 patients who underwent metastasectomy of pulmonary nodules arising from osteosarcomas or soft tissue sarcomas at our institute between 2005 and 2020. Overall and recurrence-free survival intervals were determined using univariate and multivariate analyses.
Results
A tumor doubling time > 1 month and a primary tumor histological type of osteosarcoma were independent predictors of longer overall survival on multivariate analysis (hazard ratios: 3.618 and 2.979,
p
= 0.00986 and 0.0373, respectively). Moreover, a > 1-month tumor doubling time and > 10-cm diameter of the primary tumor were independent predictors of longer recurrence-free survival (hazard ratios: 3.293 and 2.67,
p
= 0.0121 and 0.0134, respectively). Patients who underwent repeat pulmonary metastasectomy after complete resection of sarcoma-derived pulmonary metastases had significantly longer overall survival than those who did not (median: 5.91 years vs. 0.81 years,
p
< 0.0001).
Conclusions
Tumor doubling time is a significant predictor of clinical outcomes in patients who undergo resection of pulmonary metastases originating from sarcomas. The surgical indication for this procedure should be decided carefully, particularly for patients with metastatic lesion doubling times ≤ 1 month.</description><subject>Bone cancer</subject><subject>Bone Neoplasms - surgery</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Chemotherapy</subject><subject>Histology</subject><subject>Humans</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - pathology</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastasectomy - methods</subject><subject>Metastasis</subject><subject>Multivariate analysis</subject><subject>Original Article</subject><subject>Osteosarcoma - surgery</subject><subject>Ostomy</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Sarcoma</subject><subject>Sarcoma - surgery</subject><subject>Surgical Oncology</subject><subject>Surgical outcomes</subject><subject>Survival Rate</subject><subject>Thoracic Surgery</subject><issn>1863-6705</issn><issn>1863-6713</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kE1LJDEQhoO4-DH6BzxIwIuXdlNJOuk-iugqCB7WvS2ETCcZIt2dMdUN-u_NOrMKHoRAheSpN5WHkBNgF8CY_okAWjYV41Ax0FxVLzvkABolKqVB7H7sWb1PDhGfGKtVA_Ue2RdSSyEYPyB_f895FTvb0zi6UqeYRpoCXc_9kEabX-ngJ4tlRaQ2R4zjioacBppw8glt7tJgacoUU5joFBFnT7fHR-RHsD36421dkD83149Xt9X9w6-7q8v7qpOqnirVOs5DpwAsNC04pmsZnOscK1-DpQzc-9aLmsngvXdSMKYcd1ZazRq7bMSCnG9y1zk9zx4nM0TsfN_b0acZDa_bGgCUUAU9-4I-pTmPZTrDW2i05FrIQvEN1eWEmH0w6xyHYsMAM__cm417UwY07-7NS2k63UbPy8G7j5b_sgsgNgCWq3Hl8-fb38S-AVnZkNQ</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Omura, Akiisa</creator><creator>Kimura, Toru</creator><creator>Tanaka, Ryo</creator><creator>Hiroshima, Takashi</creator><creator>Maniwa, Tomohiro</creator><creator>Takenaka, Satoshi</creator><creator>Naka, Norifumi</creator><creator>Okami, Jiro</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4504-232X</orcidid></search><sort><creationdate>20220301</creationdate><title>Surgical indication of pulmonary metastasis arising from osteosarcoma or soft tissue sarcoma</title><author>Omura, Akiisa ; Kimura, Toru ; Tanaka, Ryo ; Hiroshima, Takashi ; Maniwa, Tomohiro ; Takenaka, Satoshi ; Naka, Norifumi ; Okami, Jiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-69d22fc611a1891d0754fddcd00211b4f2ee9e3504feeed43006d2da4a708ab83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bone cancer</topic><topic>Bone Neoplasms - surgery</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Chemotherapy</topic><topic>Histology</topic><topic>Humans</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - pathology</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastasectomy - methods</topic><topic>Metastasis</topic><topic>Multivariate analysis</topic><topic>Original Article</topic><topic>Osteosarcoma - surgery</topic><topic>Ostomy</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Sarcoma</topic><topic>Sarcoma - surgery</topic><topic>Surgical Oncology</topic><topic>Surgical outcomes</topic><topic>Survival Rate</topic><topic>Thoracic Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Omura, Akiisa</creatorcontrib><creatorcontrib>Kimura, Toru</creatorcontrib><creatorcontrib>Tanaka, Ryo</creatorcontrib><creatorcontrib>Hiroshima, Takashi</creatorcontrib><creatorcontrib>Maniwa, Tomohiro</creatorcontrib><creatorcontrib>Takenaka, Satoshi</creatorcontrib><creatorcontrib>Naka, Norifumi</creatorcontrib><creatorcontrib>Okami, Jiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>General thoracic and cardiovascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Omura, Akiisa</au><au>Kimura, Toru</au><au>Tanaka, Ryo</au><au>Hiroshima, Takashi</au><au>Maniwa, Tomohiro</au><au>Takenaka, Satoshi</au><au>Naka, Norifumi</au><au>Okami, Jiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surgical indication of pulmonary metastasis arising from osteosarcoma or soft tissue sarcoma</atitle><jtitle>General thoracic and cardiovascular surgery</jtitle><stitle>Gen Thorac Cardiovasc Surg</stitle><addtitle>Gen Thorac Cardiovasc Surg</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>70</volume><issue>3</issue><spage>273</spage><epage>279</epage><pages>273-279</pages><issn>1863-6705</issn><eissn>1863-6713</eissn><abstract>Objectives
Metastasectomy is often the local treatment for pulmonary metastases arising from osteosarcoma or soft tissue sarcoma. However, there have been few investigations on the outcomes of patients who undergo this procedure. In this study, we identified prognostic factors in patients with pulmonary metastases arising from osteosarcoma and soft tissue sarcoma to determine more appropriate eligibility criteria for metastasectomy.
Methods
We retrospectively examined 37 patients who underwent metastasectomy of pulmonary nodules arising from osteosarcomas or soft tissue sarcomas at our institute between 2005 and 2020. Overall and recurrence-free survival intervals were determined using univariate and multivariate analyses.
Results
A tumor doubling time > 1 month and a primary tumor histological type of osteosarcoma were independent predictors of longer overall survival on multivariate analysis (hazard ratios: 3.618 and 2.979,
p
= 0.00986 and 0.0373, respectively). Moreover, a > 1-month tumor doubling time and > 10-cm diameter of the primary tumor were independent predictors of longer recurrence-free survival (hazard ratios: 3.293 and 2.67,
p
= 0.0121 and 0.0134, respectively). Patients who underwent repeat pulmonary metastasectomy after complete resection of sarcoma-derived pulmonary metastases had significantly longer overall survival than those who did not (median: 5.91 years vs. 0.81 years,
p
< 0.0001).
Conclusions
Tumor doubling time is a significant predictor of clinical outcomes in patients who undergo resection of pulmonary metastases originating from sarcomas. The surgical indication for this procedure should be decided carefully, particularly for patients with metastatic lesion doubling times ≤ 1 month.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>34743302</pmid><doi>10.1007/s11748-021-01726-x</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-4504-232X</orcidid></addata></record> |
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| ispartof | General thoracic and cardiovascular surgery, 2022-03, Vol.70 (3), p.273-279 |
| issn | 1863-6705 1863-6713 |
| language | eng |
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| source | MEDLINE; ProQuest Central (Alumni Edition); ProQuest Central UK/Ireland; SpringerLink Journals - AutoHoldings; ProQuest Central |
| subjects | Bone cancer Bone Neoplasms - surgery Cardiac Surgery Cardiology Chemotherapy Histology Humans Lung cancer Lung Neoplasms - pathology Medical prognosis Medicine Medicine & Public Health Metastasectomy - methods Metastasis Multivariate analysis Original Article Osteosarcoma - surgery Ostomy Patients Prognosis Retrospective Studies Sarcoma Sarcoma - surgery Surgical Oncology Surgical outcomes Survival Rate Thoracic Surgery |
| title | Surgical indication of pulmonary metastasis arising from osteosarcoma or soft tissue sarcoma |
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