CAPE-pNO2 ameliorates diabetic brain injury through modulating Alzheimer's disease key proteins, oxidation, inflammation and autophagy via a Nrf2-dependent pathway

CAPE-pNO2, an active derivative of caffeic acid phenethyl ester, has been verified to exert protection of diabetic cardiomyopathy and diabetic nephropathy. The present study aims to explore the brain protection effects and potential mechanisms of CAPE-pNO2 on streptozotocin-induced diabetic brain in...

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Veröffentlicht in:	Life sciences (1973) 2021-12, Vol.287, p.119929-119929, Article 119929
Hauptverfasser:	Luo, Zhouxia, Wan, Qin, Han, Yanmin, Li, Zhubo, Li, Boheng
Format:	Artikel
Sprache:	eng
Schlagworte:	AD-related protein Alzheimer's disease Atrophy Autophagy Brain Brain injury Caffeic acid Cardiomyopathy Cerebral cortex Cholesterol Diabetes Diabetes mellitus Head injuries Hippocampus Immunofluorescence In vitro methods and tests In vivo methods and tests Inflammation Malondialdehyde Nephropathy Neurodegenerative diseases Nrf2 Oxidation Oxidative stress Proteins Streptozocin Superoxide dismutase Tau protein Traumatic brain injury Triglycerides
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