Hepatitis E virus and Bell’s palsy
Background and purpose Acute hepatitis E virus (HEV) infections have been associated with various neurological disorders, including individual cases with Bell's palsy. Nonetheless, systematic studies in the latter are lacking. Therefore, this retrospective study systematically screened a cohort...
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| Veröffentlicht in: | European journal of neurology 2022-03, Vol.29 (3), p.820-825 |
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| creator | Fritz‐Weltin, Miriam Niedermeier, Lisa Frommherz, Estelle Isenmann, Nora Csernalabics, Benedikt Boettler, Tobias Neumann‐Haefelin, Christoph Endres, Dominique Panning, Marcus Berger, Benjamin |
| description | Background and purpose
Acute hepatitis E virus (HEV) infections have been associated with various neurological disorders, including individual cases with Bell's palsy. Nonetheless, systematic studies in the latter are lacking. Therefore, this retrospective study systematically screened a cohort of patients with Bell's palsy for an acute HEV infection.
Methods
Overall, 104 patients with Bell's palsy treated in our clinic between 2008 and 2018 were identified. Serum samples were analyzed for anti‐HEV immunoglobulin (Ig)M and IgG antibodies by enzyme‐linked immunosorbent assay. Additionally, serum samples were tested for HEV RNA by polymerase chain reaction in 92 of these 104 patients presenting within the first 7 days from symptom onset. A large group of 263 healthy individuals served as controls.
Results
None of the patients with Bell's palsy but two healthy controls (0.8%) had an acute HEV infection. Anti‐HEV IgG seroprevalence indicating previous infection was unexpectedly high in patients with Bell's palsy (34%) and revealed an age‐dependent increase.
Conclusions
In this first systematic study, no cases of Bell's palsy in association with an acute HEV infection were identified. However, based on previous case descriptions, rare associations cannot be excluded. Therefore, large prospective multicenter studies will be necessary for conclusions that are more definitive.
This retrospective monocentric study analyzed the association of an acute hepatitis E virus (HEV) infection in 104 patients presenting with Bell’s palsy. 263 healthy individuals served as controls. None of the patients with Bell’s palsy, but two healthy controls (0.8%) had an acute HEV infection. Anti‐HEV IgG seroprevalence indicating previous infection was high in both patients (36%) and controls (17%) with an age‐dependent increase. In this first systematic study, no association of Bell’s palsy and an acute HEV infection was found. |
| doi_str_mv | 10.1111/ene.15175 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2595097601</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2627019900</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3885-5909d7cb79fe8d57cd997c370557c04aa21dea290cc745c195ca97ccd5cf0e703</originalsourceid><addsrcrecordid>eNp1kLFOwzAURS0EoqUw8AMoEgwwpH3Pjut4hCpQpAoWmC3XcaRUaRLiBpSN3-D3-BJcUhiQeMt9w9HR1SXkFGGM_ia2tGPkKPgeGWI0jUNkDPf9zziGHAEH5Mi5FQBQQeGQDFgkophyMSQXc1vrTb7JXZAEr3nTukCXaXBji-Lz_cMFtS5cd0wOMp_2ZJcj8nybPM3m4eLx7n52vQgNi2MecgkyFWYpZGbjlAuTSikME8D9D5HWFFOrqQRjRMQNSm60B0zKTQZWABuRy95bN9VLa91GrXNnfBVd2qp1inLJQYopoEfP_6Crqm1K307RKRWAUsJWeNVTpqmca2ym6iZf66ZTCGo7nfLTqe_pPHu2M7bLtU1_yZ-tPDDpgbe8sN3_JpU8JL3yCzM0dcg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2627019900</pqid></control><display><type>article</type><title>Hepatitis E virus and Bell’s palsy</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Fritz‐Weltin, Miriam ; Niedermeier, Lisa ; Frommherz, Estelle ; Isenmann, Nora ; Csernalabics, Benedikt ; Boettler, Tobias ; Neumann‐Haefelin, Christoph ; Endres, Dominique ; Panning, Marcus ; Berger, Benjamin</creator><creatorcontrib>Fritz‐Weltin, Miriam ; Niedermeier, Lisa ; Frommherz, Estelle ; Isenmann, Nora ; Csernalabics, Benedikt ; Boettler, Tobias ; Neumann‐Haefelin, Christoph ; Endres, Dominique ; Panning, Marcus ; Berger, Benjamin</creatorcontrib><description>Background and purpose
Acute hepatitis E virus (HEV) infections have been associated with various neurological disorders, including individual cases with Bell's palsy. Nonetheless, systematic studies in the latter are lacking. Therefore, this retrospective study systematically screened a cohort of patients with Bell's palsy for an acute HEV infection.
Methods
Overall, 104 patients with Bell's palsy treated in our clinic between 2008 and 2018 were identified. Serum samples were analyzed for anti‐HEV immunoglobulin (Ig)M and IgG antibodies by enzyme‐linked immunosorbent assay. Additionally, serum samples were tested for HEV RNA by polymerase chain reaction in 92 of these 104 patients presenting within the first 7 days from symptom onset. A large group of 263 healthy individuals served as controls.
Results
None of the patients with Bell's palsy but two healthy controls (0.8%) had an acute HEV infection. Anti‐HEV IgG seroprevalence indicating previous infection was unexpectedly high in patients with Bell's palsy (34%) and revealed an age‐dependent increase.
Conclusions
In this first systematic study, no cases of Bell's palsy in association with an acute HEV infection were identified. However, based on previous case descriptions, rare associations cannot be excluded. Therefore, large prospective multicenter studies will be necessary for conclusions that are more definitive.
This retrospective monocentric study analyzed the association of an acute hepatitis E virus (HEV) infection in 104 patients presenting with Bell’s palsy. 263 healthy individuals served as controls. None of the patients with Bell’s palsy, but two healthy controls (0.8%) had an acute HEV infection. Anti‐HEV IgG seroprevalence indicating previous infection was high in both patients (36%) and controls (17%) with an age‐dependent increase. In this first systematic study, no association of Bell’s palsy and an acute HEV infection was found.</description><identifier>ISSN: 1351-5101</identifier><identifier>EISSN: 1468-1331</identifier><identifier>DOI: 10.1111/ene.15175</identifier><identifier>PMID: 34748257</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Antibodies ; Bell Palsy - diagnosis ; Bell's palsy ; DNA-directed RNA polymerase ; Hepatitis ; Hepatitis E virus ; HEV seroprevalence ; Humans ; Immunoglobulin G ; Infections ; Neurological diseases ; Paralysis ; Polymerase chain reaction ; Prospective Studies ; Retrospective Studies ; Seroepidemiologic Studies ; Serology ; Viruses</subject><ispartof>European journal of neurology, 2022-03, Vol.29 (3), p.820-825</ispartof><rights>2021 The Authors. published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.</rights><rights>2021 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3885-5909d7cb79fe8d57cd997c370557c04aa21dea290cc745c195ca97ccd5cf0e703</citedby><cites>FETCH-LOGICAL-c3885-5909d7cb79fe8d57cd997c370557c04aa21dea290cc745c195ca97ccd5cf0e703</cites><orcidid>0000-0003-1031-0830</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fene.15175$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fene.15175$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34748257$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fritz‐Weltin, Miriam</creatorcontrib><creatorcontrib>Niedermeier, Lisa</creatorcontrib><creatorcontrib>Frommherz, Estelle</creatorcontrib><creatorcontrib>Isenmann, Nora</creatorcontrib><creatorcontrib>Csernalabics, Benedikt</creatorcontrib><creatorcontrib>Boettler, Tobias</creatorcontrib><creatorcontrib>Neumann‐Haefelin, Christoph</creatorcontrib><creatorcontrib>Endres, Dominique</creatorcontrib><creatorcontrib>Panning, Marcus</creatorcontrib><creatorcontrib>Berger, Benjamin</creatorcontrib><title>Hepatitis E virus and Bell’s palsy</title><title>European journal of neurology</title><addtitle>Eur J Neurol</addtitle><description>Background and purpose
Acute hepatitis E virus (HEV) infections have been associated with various neurological disorders, including individual cases with Bell's palsy. Nonetheless, systematic studies in the latter are lacking. Therefore, this retrospective study systematically screened a cohort of patients with Bell's palsy for an acute HEV infection.
Methods
Overall, 104 patients with Bell's palsy treated in our clinic between 2008 and 2018 were identified. Serum samples were analyzed for anti‐HEV immunoglobulin (Ig)M and IgG antibodies by enzyme‐linked immunosorbent assay. Additionally, serum samples were tested for HEV RNA by polymerase chain reaction in 92 of these 104 patients presenting within the first 7 days from symptom onset. A large group of 263 healthy individuals served as controls.
Results
None of the patients with Bell's palsy but two healthy controls (0.8%) had an acute HEV infection. Anti‐HEV IgG seroprevalence indicating previous infection was unexpectedly high in patients with Bell's palsy (34%) and revealed an age‐dependent increase.
Conclusions
In this first systematic study, no cases of Bell's palsy in association with an acute HEV infection were identified. However, based on previous case descriptions, rare associations cannot be excluded. Therefore, large prospective multicenter studies will be necessary for conclusions that are more definitive.
This retrospective monocentric study analyzed the association of an acute hepatitis E virus (HEV) infection in 104 patients presenting with Bell’s palsy. 263 healthy individuals served as controls. None of the patients with Bell’s palsy, but two healthy controls (0.8%) had an acute HEV infection. Anti‐HEV IgG seroprevalence indicating previous infection was high in both patients (36%) and controls (17%) with an age‐dependent increase. In this first systematic study, no association of Bell’s palsy and an acute HEV infection was found.</description><subject>Antibodies</subject><subject>Bell Palsy - diagnosis</subject><subject>Bell's palsy</subject><subject>DNA-directed RNA polymerase</subject><subject>Hepatitis</subject><subject>Hepatitis E virus</subject><subject>HEV seroprevalence</subject><subject>Humans</subject><subject>Immunoglobulin G</subject><subject>Infections</subject><subject>Neurological diseases</subject><subject>Paralysis</subject><subject>Polymerase chain reaction</subject><subject>Prospective Studies</subject><subject>Retrospective Studies</subject><subject>Seroepidemiologic Studies</subject><subject>Serology</subject><subject>Viruses</subject><issn>1351-5101</issn><issn>1468-1331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kLFOwzAURS0EoqUw8AMoEgwwpH3Pjut4hCpQpAoWmC3XcaRUaRLiBpSN3-D3-BJcUhiQeMt9w9HR1SXkFGGM_ia2tGPkKPgeGWI0jUNkDPf9zziGHAEH5Mi5FQBQQeGQDFgkophyMSQXc1vrTb7JXZAEr3nTukCXaXBji-Lz_cMFtS5cd0wOMp_2ZJcj8nybPM3m4eLx7n52vQgNi2MecgkyFWYpZGbjlAuTSikME8D9D5HWFFOrqQRjRMQNSm60B0zKTQZWABuRy95bN9VLa91GrXNnfBVd2qp1inLJQYopoEfP_6Crqm1K307RKRWAUsJWeNVTpqmca2ym6iZf66ZTCGo7nfLTqe_pPHu2M7bLtU1_yZ-tPDDpgbe8sN3_JpU8JL3yCzM0dcg</recordid><startdate>202203</startdate><enddate>202203</enddate><creator>Fritz‐Weltin, Miriam</creator><creator>Niedermeier, Lisa</creator><creator>Frommherz, Estelle</creator><creator>Isenmann, Nora</creator><creator>Csernalabics, Benedikt</creator><creator>Boettler, Tobias</creator><creator>Neumann‐Haefelin, Christoph</creator><creator>Endres, Dominique</creator><creator>Panning, Marcus</creator><creator>Berger, Benjamin</creator><general>John Wiley & Sons, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1031-0830</orcidid></search><sort><creationdate>202203</creationdate><title>Hepatitis E virus and Bell’s palsy</title><author>Fritz‐Weltin, Miriam ; Niedermeier, Lisa ; Frommherz, Estelle ; Isenmann, Nora ; Csernalabics, Benedikt ; Boettler, Tobias ; Neumann‐Haefelin, Christoph ; Endres, Dominique ; Panning, Marcus ; Berger, Benjamin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3885-5909d7cb79fe8d57cd997c370557c04aa21dea290cc745c195ca97ccd5cf0e703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antibodies</topic><topic>Bell Palsy - diagnosis</topic><topic>Bell's palsy</topic><topic>DNA-directed RNA polymerase</topic><topic>Hepatitis</topic><topic>Hepatitis E virus</topic><topic>HEV seroprevalence</topic><topic>Humans</topic><topic>Immunoglobulin G</topic><topic>Infections</topic><topic>Neurological diseases</topic><topic>Paralysis</topic><topic>Polymerase chain reaction</topic><topic>Prospective Studies</topic><topic>Retrospective Studies</topic><topic>Seroepidemiologic Studies</topic><topic>Serology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fritz‐Weltin, Miriam</creatorcontrib><creatorcontrib>Niedermeier, Lisa</creatorcontrib><creatorcontrib>Frommherz, Estelle</creatorcontrib><creatorcontrib>Isenmann, Nora</creatorcontrib><creatorcontrib>Csernalabics, Benedikt</creatorcontrib><creatorcontrib>Boettler, Tobias</creatorcontrib><creatorcontrib>Neumann‐Haefelin, Christoph</creatorcontrib><creatorcontrib>Endres, Dominique</creatorcontrib><creatorcontrib>Panning, Marcus</creatorcontrib><creatorcontrib>Berger, Benjamin</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fritz‐Weltin, Miriam</au><au>Niedermeier, Lisa</au><au>Frommherz, Estelle</au><au>Isenmann, Nora</au><au>Csernalabics, Benedikt</au><au>Boettler, Tobias</au><au>Neumann‐Haefelin, Christoph</au><au>Endres, Dominique</au><au>Panning, Marcus</au><au>Berger, Benjamin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis E virus and Bell’s palsy</atitle><jtitle>European journal of neurology</jtitle><addtitle>Eur J Neurol</addtitle><date>2022-03</date><risdate>2022</risdate><volume>29</volume><issue>3</issue><spage>820</spage><epage>825</epage><pages>820-825</pages><issn>1351-5101</issn><eissn>1468-1331</eissn><abstract>Background and purpose
Acute hepatitis E virus (HEV) infections have been associated with various neurological disorders, including individual cases with Bell's palsy. Nonetheless, systematic studies in the latter are lacking. Therefore, this retrospective study systematically screened a cohort of patients with Bell's palsy for an acute HEV infection.
Methods
Overall, 104 patients with Bell's palsy treated in our clinic between 2008 and 2018 were identified. Serum samples were analyzed for anti‐HEV immunoglobulin (Ig)M and IgG antibodies by enzyme‐linked immunosorbent assay. Additionally, serum samples were tested for HEV RNA by polymerase chain reaction in 92 of these 104 patients presenting within the first 7 days from symptom onset. A large group of 263 healthy individuals served as controls.
Results
None of the patients with Bell's palsy but two healthy controls (0.8%) had an acute HEV infection. Anti‐HEV IgG seroprevalence indicating previous infection was unexpectedly high in patients with Bell's palsy (34%) and revealed an age‐dependent increase.
Conclusions
In this first systematic study, no cases of Bell's palsy in association with an acute HEV infection were identified. However, based on previous case descriptions, rare associations cannot be excluded. Therefore, large prospective multicenter studies will be necessary for conclusions that are more definitive.
This retrospective monocentric study analyzed the association of an acute hepatitis E virus (HEV) infection in 104 patients presenting with Bell’s palsy. 263 healthy individuals served as controls. None of the patients with Bell’s palsy, but two healthy controls (0.8%) had an acute HEV infection. Anti‐HEV IgG seroprevalence indicating previous infection was high in both patients (36%) and controls (17%) with an age‐dependent increase. In this first systematic study, no association of Bell’s palsy and an acute HEV infection was found.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>34748257</pmid><doi>10.1111/ene.15175</doi><tpages>0</tpages><orcidid>https://orcid.org/0000-0003-1031-0830</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Antibodies Bell Palsy - diagnosis Bell's palsy DNA-directed RNA polymerase Hepatitis Hepatitis E virus HEV seroprevalence Humans Immunoglobulin G Infections Neurological diseases Paralysis Polymerase chain reaction Prospective Studies Retrospective Studies Seroepidemiologic Studies Serology Viruses |
| title | Hepatitis E virus and Bell’s palsy |
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