A synthetic gene circuit for imaging-free detection of signaling pulses

Cells employ intracellular signaling pathways to sense and respond to changes in their external environment. In recent years, live-cell biosensors have revealed complex pulsatile dynamics in many pathways, but studies of these signaling dynamics are limited by the necessity of live-cell imaging at h...

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Veröffentlicht in:	Cell systems 2022-02, Vol.13 (2), p.131-142.e13
Hauptverfasser:	Ravindran, Pavithran T., McFann, Sarah, Thornton, Richard H., Toettcher, Jared E.
Format:	Artikel
Sprache:	eng
Schlagworte:	cell signaling Gene Expression Regulation Gene Regulatory Networks - genetics Genes, Synthetic MAP Kinase Signaling System network motifs Signal Transduction - genetics signaling dynamics synthetic biology
Online-Zugang:	Volltext
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