Alpha-terpineol prevents myocardial damage against isoproterenol-MI induced in Wistar-Kyoto rats: new possible to promote cardiovascular integrity
Alpha-terpineol (TPN) is one of the major components of the resin obtained from Protium heptaphyllum. This plant has been utilized as medicine by Brazilian indigenous tribes to treat cardiovascular diseases. Scientific reports have shown that the TPN possesses vasorelaxant and antihypertensive effec...
Gespeichert in:
| Veröffentlicht in: | Life sciences (1973) 2022-02, Vol.290, p.120087-120087, Article 120087 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 120087 |
|---|---|
| container_issue | |
| container_start_page | 120087 |
| container_title | Life sciences (1973) |
| container_volume | 290 |
| creator | Paulino, Emanuel Tenório Rodrigues, Amanda Karine Barros Ferreira Machado, Maria Luiza Dal Pont de Oliveira, Kelly Rayane Vital Bernardino, Alessando César Quintans-Júnior, Lucindo José Oliveira, Aldeídia Pereira Ribeiro, Êurica Adélia Nogueira |
| description | Alpha-terpineol (TPN) is one of the major components of the resin obtained from Protium heptaphyllum. This plant has been utilized as medicine by Brazilian indigenous tribes to treat cardiovascular diseases. Scientific reports have shown that the TPN possesses vasorelaxant and antihypertensive effects. This study was conducted to assess the cardioprotective action of TPN against isoproterenol (ISO)-induced cardiotoxicity. Wistar rats were randomly divided into six groups. Rats were orally administered with TPN (25, 50, and 75 mg/kg, respectively) for 15 days, and ISO was administered (85 mg/kg, subcutaneously) on the 14th and 15th days. At the end of the experiment, the hemodynamic, baroreflex test, ECG, biochemical, histological, and morphometric changes were monitored from control and experimental groups, i.e., on the 15th day. ISO-induced myocardial infarcted rats showed an increase in mortality rates, cardiac marker enzymes, tachycardia, hypertrophy, myocardium necrosis, edema, hemorrhagic areas, infiltration of inflammatory cells like lymphocytes, and increased myocardial infarct size. However, pretreatment with TPN significantly inhibited these effects of ISO. The histopathological findings obtained for the myocardium further confirmed the biochemical results. Thus, the present study provides evidence for the efficacy of TPN against ISO-induced myocardial infarction in rats.
[Display omitted] |
| doi_str_mv | 10.1016/j.lfs.2021.120087 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2594294291</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0024320521010742</els_id><sourcerecordid>2628817255</sourcerecordid><originalsourceid>FETCH-LOGICAL-c381t-a504edda85a6163404e7b5a856fe550290b2b1f3c3efd01f363f953c2a7a4a163</originalsourceid><addsrcrecordid>eNp9kU2P0zAQhi0EYsvCD-CCLHHhkuKPOEnhtFrxsWIRFxBHa-pMiisnDrZT1L_BL2ZKFw4ckCyNx3qfV-N5GXsqxVoK2bzcr8OQ10oouZZKiK69x1ayazeVaLS8z1ZCqLrSSpgL9ijnvRDCmFY_ZBe6bmthWrNiP6_C_A2qgmn2E8bA54QHnErm4zE6SL2HwHsYYYccduCnXLjPcU6REJxiqD7ecD_1i8OeKv_qc4FUfTjGEnmCkl_xCX_wOebstwE5vRI7Es1_u8cDZLcESAQX3CVfjo_ZgwFCxid39ZJ9efvm8_X76vbTu5vrq9vK6U6WCoyose-hM9DIRtfUtVtDbTOgMUJtxFZt5aCdxqEXdGn0sDHaKWihBiIu2YuzLw30fcFc7OizwxCAFrFkq8ymVqcjSfr8H-k-Lmmi6axqVNfJVhlDKnlWuUTfTTjYOfkR0tFKYU-B2b2lwOwpMHsOjJhnd87LdsT-L_EnIRK8PguQVnHwmGx2Hidat0_oiu2j_4_9L5T9qLU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2628817255</pqid></control><display><type>article</type><title>Alpha-terpineol prevents myocardial damage against isoproterenol-MI induced in Wistar-Kyoto rats: new possible to promote cardiovascular integrity</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Paulino, Emanuel Tenório ; Rodrigues, Amanda Karine Barros Ferreira ; Machado, Maria Luiza Dal Pont ; de Oliveira, Kelly Rayane Vital ; Bernardino, Alessando César ; Quintans-Júnior, Lucindo José ; Oliveira, Aldeídia Pereira ; Ribeiro, Êurica Adélia Nogueira</creator><creatorcontrib>Paulino, Emanuel Tenório ; Rodrigues, Amanda Karine Barros Ferreira ; Machado, Maria Luiza Dal Pont ; de Oliveira, Kelly Rayane Vital ; Bernardino, Alessando César ; Quintans-Júnior, Lucindo José ; Oliveira, Aldeídia Pereira ; Ribeiro, Êurica Adélia Nogueira</creatorcontrib><description>Alpha-terpineol (TPN) is one of the major components of the resin obtained from Protium heptaphyllum. This plant has been utilized as medicine by Brazilian indigenous tribes to treat cardiovascular diseases. Scientific reports have shown that the TPN possesses vasorelaxant and antihypertensive effects. This study was conducted to assess the cardioprotective action of TPN against isoproterenol (ISO)-induced cardiotoxicity. Wistar rats were randomly divided into six groups. Rats were orally administered with TPN (25, 50, and 75 mg/kg, respectively) for 15 days, and ISO was administered (85 mg/kg, subcutaneously) on the 14th and 15th days. At the end of the experiment, the hemodynamic, baroreflex test, ECG, biochemical, histological, and morphometric changes were monitored from control and experimental groups, i.e., on the 15th day. ISO-induced myocardial infarcted rats showed an increase in mortality rates, cardiac marker enzymes, tachycardia, hypertrophy, myocardium necrosis, edema, hemorrhagic areas, infiltration of inflammatory cells like lymphocytes, and increased myocardial infarct size. However, pretreatment with TPN significantly inhibited these effects of ISO. The histopathological findings obtained for the myocardium further confirmed the biochemical results. Thus, the present study provides evidence for the efficacy of TPN against ISO-induced myocardial infarction in rats.
[Display omitted]</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2021.120087</identifier><identifier>PMID: 34740575</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Alpha-terpineol ; Animals ; Antihypertensives ; Antioxidants - pharmacology ; Baroreceptors ; Biomarkers - metabolism ; Cardioprotection ; Cardiotonic Agents - pharmacology ; Cardiotoxicity ; Cardiotoxicity - drug therapy ; Cardiotoxicity - metabolism ; Cardiovascular diseases ; Cardiovascular Diseases - drug therapy ; Cyclohexane Monoterpenes - metabolism ; Cyclohexane Monoterpenes - pharmacology ; Damage prevention ; Edema ; EKG ; Heart - drug effects ; Hemodynamics ; Hemodynamics - drug effects ; Hemorrhage ; Hypertrophy ; Inflammation ; Isoproterenol ; Isoproterenol - pharmacology ; Lipid Peroxidation - drug effects ; Lymphocytes ; Male ; Medicinal plants ; Myocardial infarction ; Myocardial Infarction - pathology ; Myocardium ; Myocardium - metabolism ; Necrosis ; Oral administration ; Protium heptaphyllum ; Rats ; Rats, Inbred WKY ; Reflexes ; Rodents ; Tachycardia ; Terpineol ; Wistar-Kyoto rats</subject><ispartof>Life sciences (1973), 2022-02, Vol.290, p.120087-120087, Article 120087</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier BV Feb 1, 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-a504edda85a6163404e7b5a856fe550290b2b1f3c3efd01f363f953c2a7a4a163</citedby><cites>FETCH-LOGICAL-c381t-a504edda85a6163404e7b5a856fe550290b2b1f3c3efd01f363f953c2a7a4a163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0024320521010742$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34740575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paulino, Emanuel Tenório</creatorcontrib><creatorcontrib>Rodrigues, Amanda Karine Barros Ferreira</creatorcontrib><creatorcontrib>Machado, Maria Luiza Dal Pont</creatorcontrib><creatorcontrib>de Oliveira, Kelly Rayane Vital</creatorcontrib><creatorcontrib>Bernardino, Alessando César</creatorcontrib><creatorcontrib>Quintans-Júnior, Lucindo José</creatorcontrib><creatorcontrib>Oliveira, Aldeídia Pereira</creatorcontrib><creatorcontrib>Ribeiro, Êurica Adélia Nogueira</creatorcontrib><title>Alpha-terpineol prevents myocardial damage against isoproterenol-MI induced in Wistar-Kyoto rats: new possible to promote cardiovascular integrity</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Alpha-terpineol (TPN) is one of the major components of the resin obtained from Protium heptaphyllum. This plant has been utilized as medicine by Brazilian indigenous tribes to treat cardiovascular diseases. Scientific reports have shown that the TPN possesses vasorelaxant and antihypertensive effects. This study was conducted to assess the cardioprotective action of TPN against isoproterenol (ISO)-induced cardiotoxicity. Wistar rats were randomly divided into six groups. Rats were orally administered with TPN (25, 50, and 75 mg/kg, respectively) for 15 days, and ISO was administered (85 mg/kg, subcutaneously) on the 14th and 15th days. At the end of the experiment, the hemodynamic, baroreflex test, ECG, biochemical, histological, and morphometric changes were monitored from control and experimental groups, i.e., on the 15th day. ISO-induced myocardial infarcted rats showed an increase in mortality rates, cardiac marker enzymes, tachycardia, hypertrophy, myocardium necrosis, edema, hemorrhagic areas, infiltration of inflammatory cells like lymphocytes, and increased myocardial infarct size. However, pretreatment with TPN significantly inhibited these effects of ISO. The histopathological findings obtained for the myocardium further confirmed the biochemical results. Thus, the present study provides evidence for the efficacy of TPN against ISO-induced myocardial infarction in rats.
[Display omitted]</description><subject>Alpha-terpineol</subject><subject>Animals</subject><subject>Antihypertensives</subject><subject>Antioxidants - pharmacology</subject><subject>Baroreceptors</subject><subject>Biomarkers - metabolism</subject><subject>Cardioprotection</subject><subject>Cardiotonic Agents - pharmacology</subject><subject>Cardiotoxicity</subject><subject>Cardiotoxicity - drug therapy</subject><subject>Cardiotoxicity - metabolism</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - drug therapy</subject><subject>Cyclohexane Monoterpenes - metabolism</subject><subject>Cyclohexane Monoterpenes - pharmacology</subject><subject>Damage prevention</subject><subject>Edema</subject><subject>EKG</subject><subject>Heart - drug effects</subject><subject>Hemodynamics</subject><subject>Hemodynamics - drug effects</subject><subject>Hemorrhage</subject><subject>Hypertrophy</subject><subject>Inflammation</subject><subject>Isoproterenol</subject><subject>Isoproterenol - pharmacology</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medicinal plants</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - pathology</subject><subject>Myocardium</subject><subject>Myocardium - metabolism</subject><subject>Necrosis</subject><subject>Oral administration</subject><subject>Protium heptaphyllum</subject><subject>Rats</subject><subject>Rats, Inbred WKY</subject><subject>Reflexes</subject><subject>Rodents</subject><subject>Tachycardia</subject><subject>Terpineol</subject><subject>Wistar-Kyoto rats</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2P0zAQhi0EYsvCD-CCLHHhkuKPOEnhtFrxsWIRFxBHa-pMiisnDrZT1L_BL2ZKFw4ckCyNx3qfV-N5GXsqxVoK2bzcr8OQ10oouZZKiK69x1ayazeVaLS8z1ZCqLrSSpgL9ijnvRDCmFY_ZBe6bmthWrNiP6_C_A2qgmn2E8bA54QHnErm4zE6SL2HwHsYYYccduCnXLjPcU6REJxiqD7ecD_1i8OeKv_qc4FUfTjGEnmCkl_xCX_wOebstwE5vRI7Es1_u8cDZLcESAQX3CVfjo_ZgwFCxid39ZJ9efvm8_X76vbTu5vrq9vK6U6WCoyose-hM9DIRtfUtVtDbTOgMUJtxFZt5aCdxqEXdGn0sDHaKWihBiIu2YuzLw30fcFc7OizwxCAFrFkq8ymVqcjSfr8H-k-Lmmi6axqVNfJVhlDKnlWuUTfTTjYOfkR0tFKYU-B2b2lwOwpMHsOjJhnd87LdsT-L_EnIRK8PguQVnHwmGx2Hidat0_oiu2j_4_9L5T9qLU</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Paulino, Emanuel Tenório</creator><creator>Rodrigues, Amanda Karine Barros Ferreira</creator><creator>Machado, Maria Luiza Dal Pont</creator><creator>de Oliveira, Kelly Rayane Vital</creator><creator>Bernardino, Alessando César</creator><creator>Quintans-Júnior, Lucindo José</creator><creator>Oliveira, Aldeídia Pereira</creator><creator>Ribeiro, Êurica Adélia Nogueira</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20220201</creationdate><title>Alpha-terpineol prevents myocardial damage against isoproterenol-MI induced in Wistar-Kyoto rats: new possible to promote cardiovascular integrity</title><author>Paulino, Emanuel Tenório ; Rodrigues, Amanda Karine Barros Ferreira ; Machado, Maria Luiza Dal Pont ; de Oliveira, Kelly Rayane Vital ; Bernardino, Alessando César ; Quintans-Júnior, Lucindo José ; Oliveira, Aldeídia Pereira ; Ribeiro, Êurica Adélia Nogueira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-a504edda85a6163404e7b5a856fe550290b2b1f3c3efd01f363f953c2a7a4a163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alpha-terpineol</topic><topic>Animals</topic><topic>Antihypertensives</topic><topic>Antioxidants - pharmacology</topic><topic>Baroreceptors</topic><topic>Biomarkers - metabolism</topic><topic>Cardioprotection</topic><topic>Cardiotonic Agents - pharmacology</topic><topic>Cardiotoxicity</topic><topic>Cardiotoxicity - drug therapy</topic><topic>Cardiotoxicity - metabolism</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - drug therapy</topic><topic>Cyclohexane Monoterpenes - metabolism</topic><topic>Cyclohexane Monoterpenes - pharmacology</topic><topic>Damage prevention</topic><topic>Edema</topic><topic>EKG</topic><topic>Heart - drug effects</topic><topic>Hemodynamics</topic><topic>Hemodynamics - drug effects</topic><topic>Hemorrhage</topic><topic>Hypertrophy</topic><topic>Inflammation</topic><topic>Isoproterenol</topic><topic>Isoproterenol - pharmacology</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Medicinal plants</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - pathology</topic><topic>Myocardium</topic><topic>Myocardium - metabolism</topic><topic>Necrosis</topic><topic>Oral administration</topic><topic>Protium heptaphyllum</topic><topic>Rats</topic><topic>Rats, Inbred WKY</topic><topic>Reflexes</topic><topic>Rodents</topic><topic>Tachycardia</topic><topic>Terpineol</topic><topic>Wistar-Kyoto rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paulino, Emanuel Tenório</creatorcontrib><creatorcontrib>Rodrigues, Amanda Karine Barros Ferreira</creatorcontrib><creatorcontrib>Machado, Maria Luiza Dal Pont</creatorcontrib><creatorcontrib>de Oliveira, Kelly Rayane Vital</creatorcontrib><creatorcontrib>Bernardino, Alessando César</creatorcontrib><creatorcontrib>Quintans-Júnior, Lucindo José</creatorcontrib><creatorcontrib>Oliveira, Aldeídia Pereira</creatorcontrib><creatorcontrib>Ribeiro, Êurica Adélia Nogueira</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paulino, Emanuel Tenório</au><au>Rodrigues, Amanda Karine Barros Ferreira</au><au>Machado, Maria Luiza Dal Pont</au><au>de Oliveira, Kelly Rayane Vital</au><au>Bernardino, Alessando César</au><au>Quintans-Júnior, Lucindo José</au><au>Oliveira, Aldeídia Pereira</au><au>Ribeiro, Êurica Adélia Nogueira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alpha-terpineol prevents myocardial damage against isoproterenol-MI induced in Wistar-Kyoto rats: new possible to promote cardiovascular integrity</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>290</volume><spage>120087</spage><epage>120087</epage><pages>120087-120087</pages><artnum>120087</artnum><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Alpha-terpineol (TPN) is one of the major components of the resin obtained from Protium heptaphyllum. This plant has been utilized as medicine by Brazilian indigenous tribes to treat cardiovascular diseases. Scientific reports have shown that the TPN possesses vasorelaxant and antihypertensive effects. This study was conducted to assess the cardioprotective action of TPN against isoproterenol (ISO)-induced cardiotoxicity. Wistar rats were randomly divided into six groups. Rats were orally administered with TPN (25, 50, and 75 mg/kg, respectively) for 15 days, and ISO was administered (85 mg/kg, subcutaneously) on the 14th and 15th days. At the end of the experiment, the hemodynamic, baroreflex test, ECG, biochemical, histological, and morphometric changes were monitored from control and experimental groups, i.e., on the 15th day. ISO-induced myocardial infarcted rats showed an increase in mortality rates, cardiac marker enzymes, tachycardia, hypertrophy, myocardium necrosis, edema, hemorrhagic areas, infiltration of inflammatory cells like lymphocytes, and increased myocardial infarct size. However, pretreatment with TPN significantly inhibited these effects of ISO. The histopathological findings obtained for the myocardium further confirmed the biochemical results. Thus, the present study provides evidence for the efficacy of TPN against ISO-induced myocardial infarction in rats.
[Display omitted]</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>34740575</pmid><doi>10.1016/j.lfs.2021.120087</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 2022-02, Vol.290, p.120087-120087, Article 120087 |
| issn | 0024-3205 1879-0631 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2594294291 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alpha-terpineol Animals Antihypertensives Antioxidants - pharmacology Baroreceptors Biomarkers - metabolism Cardioprotection Cardiotonic Agents - pharmacology Cardiotoxicity Cardiotoxicity - drug therapy Cardiotoxicity - metabolism Cardiovascular diseases Cardiovascular Diseases - drug therapy Cyclohexane Monoterpenes - metabolism Cyclohexane Monoterpenes - pharmacology Damage prevention Edema EKG Heart - drug effects Hemodynamics Hemodynamics - drug effects Hemorrhage Hypertrophy Inflammation Isoproterenol Isoproterenol - pharmacology Lipid Peroxidation - drug effects Lymphocytes Male Medicinal plants Myocardial infarction Myocardial Infarction - pathology Myocardium Myocardium - metabolism Necrosis Oral administration Protium heptaphyllum Rats Rats, Inbred WKY Reflexes Rodents Tachycardia Terpineol Wistar-Kyoto rats |
| title | Alpha-terpineol prevents myocardial damage against isoproterenol-MI induced in Wistar-Kyoto rats: new possible to promote cardiovascular integrity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T10%3A17%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Alpha-terpineol%20prevents%20myocardial%20damage%20against%20isoproterenol-MI%20induced%20in%20Wistar-Kyoto%20rats:%20new%20possible%20to%20promote%20cardiovascular%20integrity&rft.jtitle=Life%20sciences%20(1973)&rft.au=Paulino,%20Emanuel%20Ten%C3%B3rio&rft.date=2022-02-01&rft.volume=290&rft.spage=120087&rft.epage=120087&rft.pages=120087-120087&rft.artnum=120087&rft.issn=0024-3205&rft.eissn=1879-0631&rft_id=info:doi/10.1016/j.lfs.2021.120087&rft_dat=%3Cproquest_cross%3E2628817255%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2628817255&rft_id=info:pmid/34740575&rft_els_id=S0024320521010742&rfr_iscdi=true |