From molecular dynamics to quantum mechanics of misfolded proteins and amyloid-like macroaggregates applied to neurodegenerative diseases

A misfolded protein compared with its native state lacks its biological function resulting in cell dysregulations and often death. Outdated hypotheses on protein folding must be revised: More realistic molecular models, focusing not only on classical molecular dynamics (MD) but also on ab initio qua...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of molecular graphics & modelling 2022-01, Vol.110, p.108046-108046, Article 108046
1. Verfasser:	Gillet, Jean-Numa
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid Density functional theory Humans Misfolded proteins Molecular dynamics Molecular Dynamics Simulation Neurodegenerative Diseases Prions Protein Folding Quantum mechanics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!