PNPLA3 is the dominant SNP linked to liver disease severity at time of first referral to a tertiary center

Single nucleotide polymorphisms (SNPs) in genes including PNPLA3, TM6SF2, HSD17B13 and SERPINA1 have been identified as risk modifiers of progression in chronic liver disease (CLD). However, it is unclear whether genotyping for these risk variants is useful in clinical routine. Liver disease severit...

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Veröffentlicht in:	Digestive and liver disease 2022-01, Vol.54 (1), p.84-90
Hauptverfasser:	Balcar, Lorenz, Semmler, Georg, Oberkofler, Hannes, Zandanell, Stephan, Strasser, Michael, Datz, Leonora, Niederseer, David, Feldman, Alexandra, Stickel, Felix, Datz, Christian, Paulweber, Bernhard, Aigner, Elmar
Format:	Artikel
Sprache:	eng
Schlagworte:	17-Hydroxysteroid Dehydrogenases - genetics Acyltransferases - genetics Alleles alpha 1-Antitrypsin - genetics Chronic Disease Cirrhosis Cross-Sectional Studies Female Genetic Markers - genetics Genetic risk Genotype HSD17B13 Humans Liver - pathology Liver Diseases - genetics Male Membrane Proteins - genetics Middle Aged Non-alcoholic Fatty Liver Disease - genetics Phospholipases A2, Calcium-Independent - genetics PNPLA3 Polymorphism, Single Nucleotide - genetics Referral and Consultation Retrospective Studies Risk Factors SERPINA1 Severity of Illness Index TM6SF2
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