Febuxostat treatment attenuates oxidative stress and inflammation due to ischemia-reperfusion injury through the necrotic pathway in skin flap of animal model

Ischemia-reperfusion (I/R) injury is a major contributor to skin flap necrosis, which is a serious complication of reconstructive surgery. The purpose of this study was to evaluate the protective effect of treatment with febuxostat, a selective xanthine oxidase inhibitor, on I/R injury in the skin f...

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Veröffentlicht in:	Free radical biology & medicine 2021-12, Vol.177, p.238-246
Hauptverfasser:	Odake, Kazuya, Tsujii, Masaya, Iino, Takahiro, Chiba, Katsura, Kataoka, Takeshi, Sudo, Akihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Febuxostat Inflammation Inflammation - drug therapy Ischemia/reperfusion injury Necrosis Oxidative Stress Rats Rats, Sprague-Dawley Reperfusion Injury - drug therapy Skin flap
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