Phenylboronic acid modified lipid nanocarriers mediated co-delivery of immunocytokine TRAIL and gamma-secretase inhibitor to triple negative breast cancer cells and cancer stem cells
Triple negative breast cancer (TNBC) is an aggressive form of breast cancer with high rates of tumor relapse and metastasis. The existing drugs for treatment of TNBC are unable to target the cells of origin (breast cancer stem cells) of TNBC. TNF-α related apoptosis inducing ligand (TRAIL) has prope...
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| Veröffentlicht in: | Medical hypotheses 2021-12, Vol.157, p.110716-110716, Article 110716 |
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| container_title | Medical hypotheses |
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| creator | Pindiprolu, Sai Kiran S.S. Avasarala, Harani Dinakaran, Sathis Kumar |
| description | Triple negative breast cancer (TNBC) is an aggressive form of breast cancer with high rates of tumor relapse and metastasis. The existing drugs for treatment of TNBC are unable to target the cells of origin (breast cancer stem cells) of TNBC. TNF-α related apoptosis inducing ligand (TRAIL) has propensity to target TNBC cells including cancer stem cells. However, resistance to TRAIL due to activation of anti-apoptotic mechanisms is a limitation for TRAIL based anticancer therapy for TNBC. In the present study we propose an hypothesis for effective targeting of triple negative breast cancer by overcoming TRAIL resistance. |
| doi_str_mv | 10.1016/j.mehy.2021.110716 |
| format | Article |
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| ispartof | Medical hypotheses, 2021-12, Vol.157, p.110716-110716, Article 110716 |
| issn | 0306-9877 1532-2777 |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Apoptosis Cancer stem cells Death receptors Gamma-secretase Metastasis Notch Phenyl boronate Triple negative breast cancer |
| title | Phenylboronic acid modified lipid nanocarriers mediated co-delivery of immunocytokine TRAIL and gamma-secretase inhibitor to triple negative breast cancer cells and cancer stem cells |
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