Targeted delivery of miR-218 via decorated hyperbranched polyamidoamine for liver cancer regression

[Display omitted] Hepatocellular carcinoma (HCC) is one of most common causes of cancer death worldwide. MicroRNA (miRNA) replacement gene therapy is a novel approach for HCC management. MiR-218 is a promising tumor suppressor miRNA that is down-regulated in HCC. Here, our aim was the targeted deliv...

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Veröffentlicht in:	International journal of pharmaceutics 2021-12, Vol.610, p.121256-121256, Article 121256
Hauptverfasser:	Elfiky, Asmaa M., Mohamed, Rania Hassan, Abd EL-Hakam, Fatma El-Zahraa, Yassin, Mohamed A., ElHefnawi, Mahmoud
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Cell Line, Tumor Cell Proliferation Gene Expression Regulation, Neoplastic Hepatocellular carcinoma Liver Neoplasms - drug therapy Liver Neoplasms - genetics Mice MicroRNAs - genetics miR-218 Polyamidoamine Polyamines Targeted therapy Tumor-suppressor miRNA
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