Heat-Induced Flower Nanogels of Both Cholesterol End-Capped Poly(N‑isopropylacrylamide)s in Water
Thermoresponsive self-assembled nanogels were conveniently prepared by cholesterol end-capped poly(N-isopropylacrylamide) (PNIPAM) in water. Both cholesterol end-capped PNIPAMs (telelchelic cholesterol PNIPAM, tCH-PNIPAM) formed flower-like nanogels by the self-assembling of four to five polymer ch...
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| Veröffentlicht in: | Langmuir 2022-05, Vol.38 (17), p.5218-5225 |
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| container_title | Langmuir |
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| creator | Morimoto, Nobuyuki Segui, Florence Qiu, Xing-Ping Akiyoshi, Kazunari Winnik, Françoise M |
| description | Thermoresponsive self-assembled nanogels were conveniently prepared by cholesterol end-capped poly(N-isopropylacrylamide) (PNIPAM) in water. Both cholesterol end-capped PNIPAMs (telelchelic cholesterol PNIPAM, tCH-PNIPAM) formed flower-like nanogels by the self-assembling of four to five polymer chains with multiple domains of cholesterol in water at 20 °C. Meanwhile, one end-group cholesterol-capped PNIPAM (semitelechelic cholesterol PNIPAM, stCH-PNIPAM) was also formed as a nanogel by the self-assembling of 15–20 polymer chains with 3 to 4 cholesterol domains. The hydrophobic cholesterol domains of tCH-PNIPAM nanogels were maintained above the lower critical solution temperature (LCST) of PNIPAM (>32 °C). Differently, the hydrophobic domains of stCH-PNIPAM were disrupted by cholesterol-free PNIPAM chain ends and formed large mesoglobules above the LCST. These transition controls of hydrophilic end-capped smart polymers may open new methodologies to design thermoresponsive nanosystems. |
| doi_str_mv | 10.1021/acs.langmuir.1c02394 |
| format | Article |
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Both cholesterol end-capped PNIPAMs (telelchelic cholesterol PNIPAM, tCH-PNIPAM) formed flower-like nanogels by the self-assembling of four to five polymer chains with multiple domains of cholesterol in water at 20 °C. Meanwhile, one end-group cholesterol-capped PNIPAM (semitelechelic cholesterol PNIPAM, stCH-PNIPAM) was also formed as a nanogel by the self-assembling of 15–20 polymer chains with 3 to 4 cholesterol domains. The hydrophobic cholesterol domains of tCH-PNIPAM nanogels were maintained above the lower critical solution temperature (LCST) of PNIPAM (>32 °C). Differently, the hydrophobic domains of stCH-PNIPAM were disrupted by cholesterol-free PNIPAM chain ends and formed large mesoglobules above the LCST. These transition controls of hydrophilic end-capped smart polymers may open new methodologies to design thermoresponsive nanosystems.</description><identifier>ISSN: 0743-7463</identifier><identifier>EISSN: 1520-5827</identifier><identifier>DOI: 10.1021/acs.langmuir.1c02394</identifier><identifier>PMID: 34730981</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Acrylic Resins ; Cholesterol - chemistry ; Hot Temperature ; Nanogels ; Polymers - chemistry ; Temperature ; Water</subject><ispartof>Langmuir, 2022-05, Vol.38 (17), p.5218-5225</ispartof><rights>2021 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a348t-be0d157a47eb5c27feba189171276ca062702cd8ee9262f21d0b80c2ff54e3e33</citedby><cites>FETCH-LOGICAL-a348t-be0d157a47eb5c27feba189171276ca062702cd8ee9262f21d0b80c2ff54e3e33</cites><orcidid>0000-0002-7620-3352 ; 0000-0001-5844-6687</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.langmuir.1c02394$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.langmuir.1c02394$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2763,27074,27922,27923,56736,56786</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34730981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morimoto, Nobuyuki</creatorcontrib><creatorcontrib>Segui, Florence</creatorcontrib><creatorcontrib>Qiu, Xing-Ping</creatorcontrib><creatorcontrib>Akiyoshi, Kazunari</creatorcontrib><creatorcontrib>Winnik, Françoise M</creatorcontrib><title>Heat-Induced Flower Nanogels of Both Cholesterol End-Capped Poly(N‑isopropylacrylamide)s in Water</title><title>Langmuir</title><addtitle>Langmuir</addtitle><description>Thermoresponsive self-assembled nanogels were conveniently prepared by cholesterol end-capped poly(N-isopropylacrylamide) (PNIPAM) in water. Both cholesterol end-capped PNIPAMs (telelchelic cholesterol PNIPAM, tCH-PNIPAM) formed flower-like nanogels by the self-assembling of four to five polymer chains with multiple domains of cholesterol in water at 20 °C. Meanwhile, one end-group cholesterol-capped PNIPAM (semitelechelic cholesterol PNIPAM, stCH-PNIPAM) was also formed as a nanogel by the self-assembling of 15–20 polymer chains with 3 to 4 cholesterol domains. The hydrophobic cholesterol domains of tCH-PNIPAM nanogels were maintained above the lower critical solution temperature (LCST) of PNIPAM (>32 °C). Differently, the hydrophobic domains of stCH-PNIPAM were disrupted by cholesterol-free PNIPAM chain ends and formed large mesoglobules above the LCST. These transition controls of hydrophilic end-capped smart polymers may open new methodologies to design thermoresponsive nanosystems.</description><subject>Acrylic Resins</subject><subject>Cholesterol - chemistry</subject><subject>Hot Temperature</subject><subject>Nanogels</subject><subject>Polymers - chemistry</subject><subject>Temperature</subject><subject>Water</subject><issn>0743-7463</issn><issn>1520-5827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLlOxDAQhi0EguV4A4RSQpFlfMVJCavlkBBQgCgjx5lAkBMHeyO0Ha_AK_IkGO1CSTPTfP8cHyGHFKYUGD3VJkyt7p-7sfVTaoDxQmyQCZUMUpkztUkmoARPlcj4DtkN4RUACi6KbbLDheJQ5HRCzBXqRXrd16PBOrmw7h19cqt794w2JK5Jzt3iJZm9OIthgd7ZZN7X6UwPQ8TvnV0e3359fLbBDd4NS6uNj6VrazwJSdsnTzqG9slWo23Ag3XfI48X84fZVXpzd3k9O7tJNRf5Iq0QaiqVFgoraZhqsNI0L6iiTGVGQ8YUMFPniAXLWMNoDVUOhjWNFMiR8z1yvJobb3kb471l1waDNlpCN4aSyYLLIpMgIypWqPEuBI9NOfi2035ZUih_9JZRb_mrt1zrjbGj9Yax6rD-C_36jACsgJ_4qxt9Hx_-f-Y39LCLlw</recordid><startdate>20220503</startdate><enddate>20220503</enddate><creator>Morimoto, Nobuyuki</creator><creator>Segui, Florence</creator><creator>Qiu, Xing-Ping</creator><creator>Akiyoshi, Kazunari</creator><creator>Winnik, Françoise M</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7620-3352</orcidid><orcidid>https://orcid.org/0000-0001-5844-6687</orcidid></search><sort><creationdate>20220503</creationdate><title>Heat-Induced Flower Nanogels of Both Cholesterol End-Capped Poly(N‑isopropylacrylamide)s in Water</title><author>Morimoto, Nobuyuki ; Segui, Florence ; Qiu, Xing-Ping ; Akiyoshi, Kazunari ; Winnik, Françoise M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a348t-be0d157a47eb5c27feba189171276ca062702cd8ee9262f21d0b80c2ff54e3e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acrylic Resins</topic><topic>Cholesterol - chemistry</topic><topic>Hot Temperature</topic><topic>Nanogels</topic><topic>Polymers - chemistry</topic><topic>Temperature</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morimoto, Nobuyuki</creatorcontrib><creatorcontrib>Segui, Florence</creatorcontrib><creatorcontrib>Qiu, Xing-Ping</creatorcontrib><creatorcontrib>Akiyoshi, Kazunari</creatorcontrib><creatorcontrib>Winnik, Françoise M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Langmuir</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morimoto, Nobuyuki</au><au>Segui, Florence</au><au>Qiu, Xing-Ping</au><au>Akiyoshi, Kazunari</au><au>Winnik, Françoise M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heat-Induced Flower Nanogels of Both Cholesterol End-Capped Poly(N‑isopropylacrylamide)s in Water</atitle><jtitle>Langmuir</jtitle><addtitle>Langmuir</addtitle><date>2022-05-03</date><risdate>2022</risdate><volume>38</volume><issue>17</issue><spage>5218</spage><epage>5225</epage><pages>5218-5225</pages><issn>0743-7463</issn><eissn>1520-5827</eissn><abstract>Thermoresponsive self-assembled nanogels were conveniently prepared by cholesterol end-capped poly(N-isopropylacrylamide) (PNIPAM) in water. Both cholesterol end-capped PNIPAMs (telelchelic cholesterol PNIPAM, tCH-PNIPAM) formed flower-like nanogels by the self-assembling of four to five polymer chains with multiple domains of cholesterol in water at 20 °C. Meanwhile, one end-group cholesterol-capped PNIPAM (semitelechelic cholesterol PNIPAM, stCH-PNIPAM) was also formed as a nanogel by the self-assembling of 15–20 polymer chains with 3 to 4 cholesterol domains. The hydrophobic cholesterol domains of tCH-PNIPAM nanogels were maintained above the lower critical solution temperature (LCST) of PNIPAM (>32 °C). Differently, the hydrophobic domains of stCH-PNIPAM were disrupted by cholesterol-free PNIPAM chain ends and formed large mesoglobules above the LCST. These transition controls of hydrophilic end-capped smart polymers may open new methodologies to design thermoresponsive nanosystems.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>34730981</pmid><doi>10.1021/acs.langmuir.1c02394</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7620-3352</orcidid><orcidid>https://orcid.org/0000-0001-5844-6687</orcidid></addata></record> |
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| source | MEDLINE; ACS Publications |
| subjects | Acrylic Resins Cholesterol - chemistry Hot Temperature Nanogels Polymers - chemistry Temperature Water |
| title | Heat-Induced Flower Nanogels of Both Cholesterol End-Capped Poly(N‑isopropylacrylamide)s in Water |
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