Higher bacterial DNAemia can affect the impact of a polyphenol-rich dietary pattern on biomarkers of intestinal permeability and cardiovascular risk in older subjects
Purpose Aging can be characterized by increased systemic low-grade inflammation, altered gut microbiota composition, and increased intestinal permeability (IP). The intake of polyphenol-rich foods is proposed as a promising strategy to positively affect the gut microbiota–immune system–intestinal ba...
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| Veröffentlicht in: | European journal of nutrition 2022-04, Vol.61 (3), p.1209-1220 |
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| creator | Gargari, Giorgio Taverniti, Valentina Del Bo’, Cristian Bernardi, Stefano Hidalgo-Liberona, Nicole Meroño, Tomás Andres-Lacueva, Cristina Kroon, Paul A. Cherubini, Antonio Riso, Patrizia Guglielmetti, Simone |
| description | Purpose
Aging can be characterized by increased systemic low-grade inflammation, altered gut microbiota composition, and increased intestinal permeability (IP). The intake of polyphenol-rich foods is proposed as a promising strategy to positively affect the gut microbiota–immune system–intestinal barrier (IB) axis. In this context, we tested the hypothesis that a PR-dietary intervention would affect the presence of bacterial factors in the bloodstream of older adults.
Methods
We collected blood samples within a randomized, controlled, crossover intervention trial in which older volunteers (
n
= 51) received a polyphenol-enriched and a control diet. We quantified the presence of bacterial DNA in blood by qPCR targeting the 16S rRNA gene (16S; bacterial DNAemia). Blood DNA was taxonomically profiled via 16S sequencing.
Results
Higher blood 16S levels were associated with higher BMI and markers of IP, inflammation, and dyslipidemia. PR-intervention did not significantly change bacterial DNAemia in the older population (
P
= 0.103). Nonetheless, the beneficial changes caused by the polyphenol-enriched diet were greatest in participants with higher bacterial DNAemia, specifically in markers related to IP, inflammation and dyslipidemia, and in fecal bacterial taxa. Finally, we found that the bacterial DNA detected in blood mostly belonged to γ-Proteobacteria, whose abundance significantly decreased after the polyphenol-rich diet in subjects with higher bacterial DNAemia at baseline.
Conclusions
This study shows that older subjects with higher bacterial DNAemia experienced a beneficial effect from a polyphenol-rich diet. Bacterial DNAemia may be a further relevant marker for the identification of target populations that could benefit more from a protective dietary treatment.
Registration
This trial was retrospectively registered at
www.isrctn.org
(ISRCTN10214981) on April 28, 2017. |
| doi_str_mv | 10.1007/s00394-021-02680-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2593033422</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2638856698</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-739f8501b7a1d210194b598ca948efca6dea8ee6793e375f58384b3808aa0f963</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhSMEoqXwAiyQJTZsAv5JHHtZlZ8iVbCBtTVxJr2-deJgJ5XuC_GcTLmlSCxYWLbk75w59qmql4K_FZx37wrnyjY1l4KWNrxWj6pT0Shdaynaxw9n3p1Uz0rZc86l0uJpdaKaTnaSy9Pq52W43mFmPfgVc4DI3n85xykA8zAzGEf0K1t3yMK0EMLSyIAtKR6WHc4p1jn4HRsCrpAPbIGVTGaWZtaHNEG-wVzuJGFesaxhJvsF84TQhxjWA4N5oDl5COkWit8iZJZDuSGepThQrLL1e0pQnldPRogFX9zvZ9X3jx--XVzWV18_fb44v6q96tq17pQdTctF34EYpODCNn1rjQfbGBw96AHBIOrOKiTB2Bplml4ZbgD4aLU6q94cfZecfmyU2U2heIwRZkxbcbK1iivVSEno63_QfdoyPZEorYxptbaGKHmkfE6lZBzdkgP9zMEJ7u5adMcWHbXofrfoFIle3Vtv_YTDg-RPbQSoI1Doar7G_Hf2f2x_AaKDqh0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2638856698</pqid></control><display><type>article</type><title>Higher bacterial DNAemia can affect the impact of a polyphenol-rich dietary pattern on biomarkers of intestinal permeability and cardiovascular risk in older subjects</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Gargari, Giorgio ; Taverniti, Valentina ; Del Bo’, Cristian ; Bernardi, Stefano ; Hidalgo-Liberona, Nicole ; Meroño, Tomás ; Andres-Lacueva, Cristina ; Kroon, Paul A. ; Cherubini, Antonio ; Riso, Patrizia ; Guglielmetti, Simone</creator><creatorcontrib>Gargari, Giorgio ; Taverniti, Valentina ; Del Bo’, Cristian ; Bernardi, Stefano ; Hidalgo-Liberona, Nicole ; Meroño, Tomás ; Andres-Lacueva, Cristina ; Kroon, Paul A. ; Cherubini, Antonio ; Riso, Patrizia ; Guglielmetti, Simone</creatorcontrib><description>Purpose
Aging can be characterized by increased systemic low-grade inflammation, altered gut microbiota composition, and increased intestinal permeability (IP). The intake of polyphenol-rich foods is proposed as a promising strategy to positively affect the gut microbiota–immune system–intestinal barrier (IB) axis. In this context, we tested the hypothesis that a PR-dietary intervention would affect the presence of bacterial factors in the bloodstream of older adults.
Methods
We collected blood samples within a randomized, controlled, crossover intervention trial in which older volunteers (
n
= 51) received a polyphenol-enriched and a control diet. We quantified the presence of bacterial DNA in blood by qPCR targeting the 16S rRNA gene (16S; bacterial DNAemia). Blood DNA was taxonomically profiled via 16S sequencing.
Results
Higher blood 16S levels were associated with higher BMI and markers of IP, inflammation, and dyslipidemia. PR-intervention did not significantly change bacterial DNAemia in the older population (
P
= 0.103). Nonetheless, the beneficial changes caused by the polyphenol-enriched diet were greatest in participants with higher bacterial DNAemia, specifically in markers related to IP, inflammation and dyslipidemia, and in fecal bacterial taxa. Finally, we found that the bacterial DNA detected in blood mostly belonged to γ-Proteobacteria, whose abundance significantly decreased after the polyphenol-rich diet in subjects with higher bacterial DNAemia at baseline.
Conclusions
This study shows that older subjects with higher bacterial DNAemia experienced a beneficial effect from a polyphenol-rich diet. Bacterial DNAemia may be a further relevant marker for the identification of target populations that could benefit more from a protective dietary treatment.
Registration
This trial was retrospectively registered at
www.isrctn.org
(ISRCTN10214981) on April 28, 2017.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-021-02680-3</identifier><identifier>PMID: 34727202</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Aging ; Bacteria ; Biomarkers ; Cardiovascular diseases ; Cardiovascular Diseases - prevention & control ; Chemistry ; Chemistry and Materials Science ; Deoxyribonucleic acid ; Diet ; Digestive system ; DNA ; DNA sequencing ; Dyslipidemia ; Feces - microbiology ; Food intake ; Gastrointestinal tract ; Heart Disease Risk Factors ; Humans ; Immune system ; Inflammation ; Intestinal microflora ; Intestine ; Microbiota ; Nutrition ; Original Contribution ; Permeability ; Polyphenols - pharmacology ; Risk Factors ; RNA, Ribosomal, 16S - genetics ; rRNA 16S</subject><ispartof>European journal of nutrition, 2022-04, Vol.61 (3), p.1209-1220</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-739f8501b7a1d210194b598ca948efca6dea8ee6793e375f58384b3808aa0f963</citedby><cites>FETCH-LOGICAL-c375t-739f8501b7a1d210194b598ca948efca6dea8ee6793e375f58384b3808aa0f963</cites><orcidid>0000-0002-8673-8190</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00394-021-02680-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00394-021-02680-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34727202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gargari, Giorgio</creatorcontrib><creatorcontrib>Taverniti, Valentina</creatorcontrib><creatorcontrib>Del Bo’, Cristian</creatorcontrib><creatorcontrib>Bernardi, Stefano</creatorcontrib><creatorcontrib>Hidalgo-Liberona, Nicole</creatorcontrib><creatorcontrib>Meroño, Tomás</creatorcontrib><creatorcontrib>Andres-Lacueva, Cristina</creatorcontrib><creatorcontrib>Kroon, Paul A.</creatorcontrib><creatorcontrib>Cherubini, Antonio</creatorcontrib><creatorcontrib>Riso, Patrizia</creatorcontrib><creatorcontrib>Guglielmetti, Simone</creatorcontrib><title>Higher bacterial DNAemia can affect the impact of a polyphenol-rich dietary pattern on biomarkers of intestinal permeability and cardiovascular risk in older subjects</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>Purpose
Aging can be characterized by increased systemic low-grade inflammation, altered gut microbiota composition, and increased intestinal permeability (IP). The intake of polyphenol-rich foods is proposed as a promising strategy to positively affect the gut microbiota–immune system–intestinal barrier (IB) axis. In this context, we tested the hypothesis that a PR-dietary intervention would affect the presence of bacterial factors in the bloodstream of older adults.
Methods
We collected blood samples within a randomized, controlled, crossover intervention trial in which older volunteers (
n
= 51) received a polyphenol-enriched and a control diet. We quantified the presence of bacterial DNA in blood by qPCR targeting the 16S rRNA gene (16S; bacterial DNAemia). Blood DNA was taxonomically profiled via 16S sequencing.
Results
Higher blood 16S levels were associated with higher BMI and markers of IP, inflammation, and dyslipidemia. PR-intervention did not significantly change bacterial DNAemia in the older population (
P
= 0.103). Nonetheless, the beneficial changes caused by the polyphenol-enriched diet were greatest in participants with higher bacterial DNAemia, specifically in markers related to IP, inflammation and dyslipidemia, and in fecal bacterial taxa. Finally, we found that the bacterial DNA detected in blood mostly belonged to γ-Proteobacteria, whose abundance significantly decreased after the polyphenol-rich diet in subjects with higher bacterial DNAemia at baseline.
Conclusions
This study shows that older subjects with higher bacterial DNAemia experienced a beneficial effect from a polyphenol-rich diet. Bacterial DNAemia may be a further relevant marker for the identification of target populations that could benefit more from a protective dietary treatment.
Registration
This trial was retrospectively registered at
www.isrctn.org
(ISRCTN10214981) on April 28, 2017.</description><subject>Aged</subject><subject>Aging</subject><subject>Bacteria</subject><subject>Biomarkers</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Deoxyribonucleic acid</subject><subject>Diet</subject><subject>Digestive system</subject><subject>DNA</subject><subject>DNA sequencing</subject><subject>Dyslipidemia</subject><subject>Feces - microbiology</subject><subject>Food intake</subject><subject>Gastrointestinal tract</subject><subject>Heart Disease Risk Factors</subject><subject>Humans</subject><subject>Immune system</subject><subject>Inflammation</subject><subject>Intestinal microflora</subject><subject>Intestine</subject><subject>Microbiota</subject><subject>Nutrition</subject><subject>Original Contribution</subject><subject>Permeability</subject><subject>Polyphenols - pharmacology</subject><subject>Risk Factors</subject><subject>RNA, Ribosomal, 16S - genetics</subject><subject>rRNA 16S</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kc1u1TAQhSMEoqXwAiyQJTZsAv5JHHtZlZ8iVbCBtTVxJr2-deJgJ5XuC_GcTLmlSCxYWLbk75w59qmql4K_FZx37wrnyjY1l4KWNrxWj6pT0Shdaynaxw9n3p1Uz0rZc86l0uJpdaKaTnaSy9Pq52W43mFmPfgVc4DI3n85xykA8zAzGEf0K1t3yMK0EMLSyIAtKR6WHc4p1jn4HRsCrpAPbIGVTGaWZtaHNEG-wVzuJGFesaxhJvsF84TQhxjWA4N5oDl5COkWit8iZJZDuSGepThQrLL1e0pQnldPRogFX9zvZ9X3jx--XVzWV18_fb44v6q96tq17pQdTctF34EYpODCNn1rjQfbGBw96AHBIOrOKiTB2Bplml4ZbgD4aLU6q94cfZecfmyU2U2heIwRZkxbcbK1iivVSEno63_QfdoyPZEorYxptbaGKHmkfE6lZBzdkgP9zMEJ7u5adMcWHbXofrfoFIle3Vtv_YTDg-RPbQSoI1Doar7G_Hf2f2x_AaKDqh0</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Gargari, Giorgio</creator><creator>Taverniti, Valentina</creator><creator>Del Bo’, Cristian</creator><creator>Bernardi, Stefano</creator><creator>Hidalgo-Liberona, Nicole</creator><creator>Meroño, Tomás</creator><creator>Andres-Lacueva, Cristina</creator><creator>Kroon, Paul A.</creator><creator>Cherubini, Antonio</creator><creator>Riso, Patrizia</creator><creator>Guglielmetti, Simone</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8673-8190</orcidid></search><sort><creationdate>20220401</creationdate><title>Higher bacterial DNAemia can affect the impact of a polyphenol-rich dietary pattern on biomarkers of intestinal permeability and cardiovascular risk in older subjects</title><author>Gargari, Giorgio ; Taverniti, Valentina ; Del Bo’, Cristian ; Bernardi, Stefano ; Hidalgo-Liberona, Nicole ; Meroño, Tomás ; Andres-Lacueva, Cristina ; Kroon, Paul A. ; Cherubini, Antonio ; Riso, Patrizia ; Guglielmetti, Simone</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-739f8501b7a1d210194b598ca948efca6dea8ee6793e375f58384b3808aa0f963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aged</topic><topic>Aging</topic><topic>Bacteria</topic><topic>Biomarkers</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - prevention & control</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Deoxyribonucleic acid</topic><topic>Diet</topic><topic>Digestive system</topic><topic>DNA</topic><topic>DNA sequencing</topic><topic>Dyslipidemia</topic><topic>Feces - microbiology</topic><topic>Food intake</topic><topic>Gastrointestinal tract</topic><topic>Heart Disease Risk Factors</topic><topic>Humans</topic><topic>Immune system</topic><topic>Inflammation</topic><topic>Intestinal microflora</topic><topic>Intestine</topic><topic>Microbiota</topic><topic>Nutrition</topic><topic>Original Contribution</topic><topic>Permeability</topic><topic>Polyphenols - pharmacology</topic><topic>Risk Factors</topic><topic>RNA, Ribosomal, 16S - genetics</topic><topic>rRNA 16S</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gargari, Giorgio</creatorcontrib><creatorcontrib>Taverniti, Valentina</creatorcontrib><creatorcontrib>Del Bo’, Cristian</creatorcontrib><creatorcontrib>Bernardi, Stefano</creatorcontrib><creatorcontrib>Hidalgo-Liberona, Nicole</creatorcontrib><creatorcontrib>Meroño, Tomás</creatorcontrib><creatorcontrib>Andres-Lacueva, Cristina</creatorcontrib><creatorcontrib>Kroon, Paul A.</creatorcontrib><creatorcontrib>Cherubini, Antonio</creatorcontrib><creatorcontrib>Riso, Patrizia</creatorcontrib><creatorcontrib>Guglielmetti, Simone</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gargari, Giorgio</au><au>Taverniti, Valentina</au><au>Del Bo’, Cristian</au><au>Bernardi, Stefano</au><au>Hidalgo-Liberona, Nicole</au><au>Meroño, Tomás</au><au>Andres-Lacueva, Cristina</au><au>Kroon, Paul A.</au><au>Cherubini, Antonio</au><au>Riso, Patrizia</au><au>Guglielmetti, Simone</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Higher bacterial DNAemia can affect the impact of a polyphenol-rich dietary pattern on biomarkers of intestinal permeability and cardiovascular risk in older subjects</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>61</volume><issue>3</issue><spage>1209</spage><epage>1220</epage><pages>1209-1220</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>Purpose
Aging can be characterized by increased systemic low-grade inflammation, altered gut microbiota composition, and increased intestinal permeability (IP). The intake of polyphenol-rich foods is proposed as a promising strategy to positively affect the gut microbiota–immune system–intestinal barrier (IB) axis. In this context, we tested the hypothesis that a PR-dietary intervention would affect the presence of bacterial factors in the bloodstream of older adults.
Methods
We collected blood samples within a randomized, controlled, crossover intervention trial in which older volunteers (
n
= 51) received a polyphenol-enriched and a control diet. We quantified the presence of bacterial DNA in blood by qPCR targeting the 16S rRNA gene (16S; bacterial DNAemia). Blood DNA was taxonomically profiled via 16S sequencing.
Results
Higher blood 16S levels were associated with higher BMI and markers of IP, inflammation, and dyslipidemia. PR-intervention did not significantly change bacterial DNAemia in the older population (
P
= 0.103). Nonetheless, the beneficial changes caused by the polyphenol-enriched diet were greatest in participants with higher bacterial DNAemia, specifically in markers related to IP, inflammation and dyslipidemia, and in fecal bacterial taxa. Finally, we found that the bacterial DNA detected in blood mostly belonged to γ-Proteobacteria, whose abundance significantly decreased after the polyphenol-rich diet in subjects with higher bacterial DNAemia at baseline.
Conclusions
This study shows that older subjects with higher bacterial DNAemia experienced a beneficial effect from a polyphenol-rich diet. Bacterial DNAemia may be a further relevant marker for the identification of target populations that could benefit more from a protective dietary treatment.
Registration
This trial was retrospectively registered at
www.isrctn.org
(ISRCTN10214981) on April 28, 2017.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34727202</pmid><doi>10.1007/s00394-021-02680-3</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-8673-8190</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1436-6207 |
| ispartof | European journal of nutrition, 2022-04, Vol.61 (3), p.1209-1220 |
| issn | 1436-6207 1436-6215 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2593033422 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Aging Bacteria Biomarkers Cardiovascular diseases Cardiovascular Diseases - prevention & control Chemistry Chemistry and Materials Science Deoxyribonucleic acid Diet Digestive system DNA DNA sequencing Dyslipidemia Feces - microbiology Food intake Gastrointestinal tract Heart Disease Risk Factors Humans Immune system Inflammation Intestinal microflora Intestine Microbiota Nutrition Original Contribution Permeability Polyphenols - pharmacology Risk Factors RNA, Ribosomal, 16S - genetics rRNA 16S |
| title | Higher bacterial DNAemia can affect the impact of a polyphenol-rich dietary pattern on biomarkers of intestinal permeability and cardiovascular risk in older subjects |
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