Comorbid diseases associated with pemphigus: a case‐control study
Summary Background and objectives Pemphigus has been associated with physical and psychiatric comorbid diseases. This study aims to further investigate these associations in patients with pemphigus, and to analyze the relationships of comorbid conditions with sex and age, pemphigus disease area inde...
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| Veröffentlicht in: | Journal der Deutschen Dermatologischen Gesellschaft 2021-11, Vol.19 (11), p.1613-1619 |
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| container_title | Journal der Deutschen Dermatologischen Gesellschaft |
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| creator | Bardazzi, Federico Rucci, Paola Rosa, Simona Loi, Camilla Iommi, Marica Altobrando, Ambra Di |
| description | Summary
Background and objectives
Pemphigus has been associated with physical and psychiatric comorbid diseases. This study aims to further investigate these associations in patients with pemphigus, and to analyze the relationships of comorbid conditions with sex and age, pemphigus disease area index score, diagnostic delay and cutaneous/mucous involvement.
Patients and methods
Patients with pemphigus were matched by age, gender and area of residence with eight controls each. The odds of comorbid conditions in patients vs. matched controls was determined using univariate conditional logistic regression models. Comorbid diseases significantly associated with the diagnosis of pemphigus at P |
| doi_str_mv | 10.1111/ddg.14595 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2593029936</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2593029936</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3535-cc219a4887d3582e1d87f613305d5c6262e2bd6ef5d176f85f467cb7763c89c83</originalsourceid><addsrcrecordid>eNp10LtOwzAUBmALgWgpDLwAisQCQ1pf4hsbSqEgVWKB2Upsp02V1CVOVHXjEXhGngRDCgMSHo7P8OnX0Q_AOYJjFN7EmMUYJVTSAzBEDMEYEsEPf3cuB-DE-xWEmAoIj8GAJBxLIfkQpKmrXZOXJjKlt5m3Psq8d7rMWmuibdkuo42tN8ty0fmbKIt0IB9v79qt28ZVkW87szsFR0VWeXu2_0fg5f7uOX2I50-zx_R2HmtCCY21xkhmiRDcECqwRUbwgiFCIDVUM8ywxblhtqAGcVYIWiSM65xzRrSQWpARuOpzN4177axvVV16basqW1vXeYWpJBBLSVigl3_oynXNOlynMEMCYxJGUNe90o3zvrGF2jRlnTU7haD6alaFZtV3s8Fe7BO7vLbmV_5UGcCkB9uysrv_k9R0OusjPwGrb4Fy</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2618223182</pqid></control><display><type>article</type><title>Comorbid diseases associated with pemphigus: a case‐control study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Bardazzi, Federico ; Rucci, Paola ; Rosa, Simona ; Loi, Camilla ; Iommi, Marica ; Altobrando, Ambra Di</creator><creatorcontrib>Bardazzi, Federico ; Rucci, Paola ; Rosa, Simona ; Loi, Camilla ; Iommi, Marica ; Altobrando, Ambra Di</creatorcontrib><description>Summary
Background and objectives
Pemphigus has been associated with physical and psychiatric comorbid diseases. This study aims to further investigate these associations in patients with pemphigus, and to analyze the relationships of comorbid conditions with sex and age, pemphigus disease area index score, diagnostic delay and cutaneous/mucous involvement.
Patients and methods
Patients with pemphigus were matched by age, gender and area of residence with eight controls each. The odds of comorbid conditions in patients vs. matched controls was determined using univariate conditional logistic regression models. Comorbid diseases significantly associated with the diagnosis of pemphigus at P < 0.05 in univariate models were subsequently included in a multivariable conditional logistic regression model with a forward procedure.
Results
The study sample included 163 patients with pemphigus. Cardiovascular diseases, hyperlipidemia, autoimmune thyroid disorders, dermatological autoimmune/inflammatory conditions and cancer were the most prominent conditions at the time of diagnosis. In the multiple conditional regression analysis, the two diagnoses independently associated with patients with pemphigus were cancer and dermatological autoimmune/inflammatory conditions. In sensitivity analyses excluding four patients with paraneoplastic pemphigus, these associations were still significant.
Conclusions
Cancer and dermatological autoimmune/inflammatory conditions may represent possible triggering conditions for pemphigus and should be considered as early warning signs for the disease.</description><identifier>ISSN: 1610-0379</identifier><identifier>EISSN: 1610-0387</identifier><identifier>DOI: 10.1111/ddg.14595</identifier><identifier>PMID: 34729897</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Autoimmune diseases ; Autoimmune Diseases - epidemiology ; Cancer ; Cardiovascular diseases ; Case-Control Studies ; Comorbidity ; Delayed Diagnosis ; Diagnosis ; Humans ; Hyperlipidemia ; Pemphigus ; Pemphigus - diagnosis ; Pemphigus - epidemiology ; Regression analysis ; Sensitivity analysis ; Skin diseases ; Thyroid</subject><ispartof>Journal der Deutschen Dermatologischen Gesellschaft, 2021-11, Vol.19 (11), p.1613-1619</ispartof><rights>2021 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-cc219a4887d3582e1d87f613305d5c6262e2bd6ef5d176f85f467cb7763c89c83</citedby><cites>FETCH-LOGICAL-c3535-cc219a4887d3582e1d87f613305d5c6262e2bd6ef5d176f85f467cb7763c89c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fddg.14595$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fddg.14595$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34729897$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bardazzi, Federico</creatorcontrib><creatorcontrib>Rucci, Paola</creatorcontrib><creatorcontrib>Rosa, Simona</creatorcontrib><creatorcontrib>Loi, Camilla</creatorcontrib><creatorcontrib>Iommi, Marica</creatorcontrib><creatorcontrib>Altobrando, Ambra Di</creatorcontrib><title>Comorbid diseases associated with pemphigus: a case‐control study</title><title>Journal der Deutschen Dermatologischen Gesellschaft</title><addtitle>J Dtsch Dermatol Ges</addtitle><description>Summary
Background and objectives
Pemphigus has been associated with physical and psychiatric comorbid diseases. This study aims to further investigate these associations in patients with pemphigus, and to analyze the relationships of comorbid conditions with sex and age, pemphigus disease area index score, diagnostic delay and cutaneous/mucous involvement.
Patients and methods
Patients with pemphigus were matched by age, gender and area of residence with eight controls each. The odds of comorbid conditions in patients vs. matched controls was determined using univariate conditional logistic regression models. Comorbid diseases significantly associated with the diagnosis of pemphigus at P < 0.05 in univariate models were subsequently included in a multivariable conditional logistic regression model with a forward procedure.
Results
The study sample included 163 patients with pemphigus. Cardiovascular diseases, hyperlipidemia, autoimmune thyroid disorders, dermatological autoimmune/inflammatory conditions and cancer were the most prominent conditions at the time of diagnosis. In the multiple conditional regression analysis, the two diagnoses independently associated with patients with pemphigus were cancer and dermatological autoimmune/inflammatory conditions. In sensitivity analyses excluding four patients with paraneoplastic pemphigus, these associations were still significant.
Conclusions
Cancer and dermatological autoimmune/inflammatory conditions may represent possible triggering conditions for pemphigus and should be considered as early warning signs for the disease.</description><subject>Autoimmune diseases</subject><subject>Autoimmune Diseases - epidemiology</subject><subject>Cancer</subject><subject>Cardiovascular diseases</subject><subject>Case-Control Studies</subject><subject>Comorbidity</subject><subject>Delayed Diagnosis</subject><subject>Diagnosis</subject><subject>Humans</subject><subject>Hyperlipidemia</subject><subject>Pemphigus</subject><subject>Pemphigus - diagnosis</subject><subject>Pemphigus - epidemiology</subject><subject>Regression analysis</subject><subject>Sensitivity analysis</subject><subject>Skin diseases</subject><subject>Thyroid</subject><issn>1610-0379</issn><issn>1610-0387</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10LtOwzAUBmALgWgpDLwAisQCQ1pf4hsbSqEgVWKB2Upsp02V1CVOVHXjEXhGngRDCgMSHo7P8OnX0Q_AOYJjFN7EmMUYJVTSAzBEDMEYEsEPf3cuB-DE-xWEmAoIj8GAJBxLIfkQpKmrXZOXJjKlt5m3Psq8d7rMWmuibdkuo42tN8ty0fmbKIt0IB9v79qt28ZVkW87szsFR0VWeXu2_0fg5f7uOX2I50-zx_R2HmtCCY21xkhmiRDcECqwRUbwgiFCIDVUM8ywxblhtqAGcVYIWiSM65xzRrSQWpARuOpzN4177axvVV16basqW1vXeYWpJBBLSVigl3_oynXNOlynMEMCYxJGUNe90o3zvrGF2jRlnTU7haD6alaFZtV3s8Fe7BO7vLbmV_5UGcCkB9uysrv_k9R0OusjPwGrb4Fy</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Bardazzi, Federico</creator><creator>Rucci, Paola</creator><creator>Rosa, Simona</creator><creator>Loi, Camilla</creator><creator>Iommi, Marica</creator><creator>Altobrando, Ambra Di</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>202111</creationdate><title>Comorbid diseases associated with pemphigus: a case‐control study</title><author>Bardazzi, Federico ; Rucci, Paola ; Rosa, Simona ; Loi, Camilla ; Iommi, Marica ; Altobrando, Ambra Di</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-cc219a4887d3582e1d87f613305d5c6262e2bd6ef5d176f85f467cb7763c89c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Autoimmune diseases</topic><topic>Autoimmune Diseases - epidemiology</topic><topic>Cancer</topic><topic>Cardiovascular diseases</topic><topic>Case-Control Studies</topic><topic>Comorbidity</topic><topic>Delayed Diagnosis</topic><topic>Diagnosis</topic><topic>Humans</topic><topic>Hyperlipidemia</topic><topic>Pemphigus</topic><topic>Pemphigus - diagnosis</topic><topic>Pemphigus - epidemiology</topic><topic>Regression analysis</topic><topic>Sensitivity analysis</topic><topic>Skin diseases</topic><topic>Thyroid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bardazzi, Federico</creatorcontrib><creatorcontrib>Rucci, Paola</creatorcontrib><creatorcontrib>Rosa, Simona</creatorcontrib><creatorcontrib>Loi, Camilla</creatorcontrib><creatorcontrib>Iommi, Marica</creatorcontrib><creatorcontrib>Altobrando, Ambra Di</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal der Deutschen Dermatologischen Gesellschaft</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bardazzi, Federico</au><au>Rucci, Paola</au><au>Rosa, Simona</au><au>Loi, Camilla</au><au>Iommi, Marica</au><au>Altobrando, Ambra Di</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comorbid diseases associated with pemphigus: a case‐control study</atitle><jtitle>Journal der Deutschen Dermatologischen Gesellschaft</jtitle><addtitle>J Dtsch Dermatol Ges</addtitle><date>2021-11</date><risdate>2021</risdate><volume>19</volume><issue>11</issue><spage>1613</spage><epage>1619</epage><pages>1613-1619</pages><issn>1610-0379</issn><eissn>1610-0387</eissn><abstract>Summary
Background and objectives
Pemphigus has been associated with physical and psychiatric comorbid diseases. This study aims to further investigate these associations in patients with pemphigus, and to analyze the relationships of comorbid conditions with sex and age, pemphigus disease area index score, diagnostic delay and cutaneous/mucous involvement.
Patients and methods
Patients with pemphigus were matched by age, gender and area of residence with eight controls each. The odds of comorbid conditions in patients vs. matched controls was determined using univariate conditional logistic regression models. Comorbid diseases significantly associated with the diagnosis of pemphigus at P < 0.05 in univariate models were subsequently included in a multivariable conditional logistic regression model with a forward procedure.
Results
The study sample included 163 patients with pemphigus. Cardiovascular diseases, hyperlipidemia, autoimmune thyroid disorders, dermatological autoimmune/inflammatory conditions and cancer were the most prominent conditions at the time of diagnosis. In the multiple conditional regression analysis, the two diagnoses independently associated with patients with pemphigus were cancer and dermatological autoimmune/inflammatory conditions. In sensitivity analyses excluding four patients with paraneoplastic pemphigus, these associations were still significant.
Conclusions
Cancer and dermatological autoimmune/inflammatory conditions may represent possible triggering conditions for pemphigus and should be considered as early warning signs for the disease.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34729897</pmid><doi>10.1111/ddg.14595</doi><tpages>7</tpages></addata></record> |
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| subjects | Autoimmune diseases Autoimmune Diseases - epidemiology Cancer Cardiovascular diseases Case-Control Studies Comorbidity Delayed Diagnosis Diagnosis Humans Hyperlipidemia Pemphigus Pemphigus - diagnosis Pemphigus - epidemiology Regression analysis Sensitivity analysis Skin diseases Thyroid |
| title | Comorbid diseases associated with pemphigus: a case‐control study |
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