Significance of Preoperative Prognostic Nutritional Index in the Perioperative Management of Gastric Cancer
Background Malnutrition leads to accelerated tumor progression through the suppression of tumor immunity. The present study examined the significance of the preoperative prognostic nutritional index (PNI) for predicting postoperative survival outcomes in gastric cancer (GC). Methods A total of 447 p...
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Veröffentlicht in: | Journal of gastrointestinal surgery 2022-03, Vol.26 (3), p.558-569 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Background
Malnutrition leads to accelerated tumor progression through the suppression of tumor immunity. The present study examined the significance of the preoperative prognostic nutritional index (PNI) for predicting postoperative survival outcomes in gastric cancer (GC).
Methods
A total of 447 patients who underwent curative gastrectomy for GC were included in the present study. PNI was calculated as 10 × serum albumin (g/dl) + 0.005 × total lymphocyte counts (per mm
3
). The prognostic impact of preoperative PNI was examined using two multivariate analysis models.
Results
The optimal cutoff value of preoperative PNI for predicting overall survival (OS) was 48 based on a receiver operating characteristic curve. The 5-year OS rate was 59.5% in the PNI |
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ISSN: | 1091-255X 1873-4626 |
DOI: | 10.1007/s11605-021-05168-x |