Association between chronic kidney disease and periodontitis. A systematic review and metanalysis
Objectives Aims of this SR were to assess the association of Periodontitis (PD) with Chronic Kidney Disease (CKD) and with different CKD stages. Materials and methods MEDLINE, Cochrane Central Register of Trials and EMBASE, up to April 4, 2021 were searched. RCTs, prospective and retrospective cohor...
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| Veröffentlicht in: | Oral diseases 2023-01, Vol.29 (1), p.40-50 |
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| creator | Serni, Lapo Caroti, Leonardo Barbato, Luigi Nieri, Michele Serni, Sergio Cirami, Calogero Lino Cairo, Francesco |
| description | Objectives
Aims of this SR were to assess the association of Periodontitis (PD) with Chronic Kidney Disease (CKD) and with different CKD stages.
Materials and methods
MEDLINE, Cochrane Central Register of Trials and EMBASE, up to April 4, 2021 were searched. RCTs, prospective and retrospective cohort studies, case–control studies and cross‐sectional studies were considered. JBI’s Critical Appraisal Tool for risk of bias assessment was used. The risk of PD was calculated using the Mantel–Haenszel odds ratios (MH‐OR); weighted mean difference for clinical attachment level (CAL) and periodontal probing depth (PPD) were also evaluated.
Results
Out of 1949 titles screened, 142 full texts were evaluated and 17 studies were included. CKD was associated to higher risk of PD (MH‐OR = 2.36, [95% C.I. 1.25, 4.44]; p = 0.008), higher mean CAL (WMD = 0.41 mm [95% C.I. 0.22, 0.60]; p |
| doi_str_mv | 10.1111/odi.14062 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2592309827</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2755408243</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4192-8e38ff59c7580ce0911b3acb25893b1e89a0acea96be8f369c033a3859ffb2e13</originalsourceid><addsrcrecordid>eNp10MFO3DAQBmCrKiqU9tAXQJZ6oYcstidO7OOK0hYJiUuRuEWOMxGmSbx4sl3l7XFZ6AEJX8aHb36Nfsa-SLGS-Z3FLqxkKSr1jh3JSshCGKXf5z_ostAKbg_ZR6J7IWRtQX1gh1DWqgKAI-bWRNEHN4c48RbnHeLE_V2KU_D8T-gmXHgXCB0hd1PHN5hC7OI0hznQiq85LTTjmPc9T_g34O6JjTi7yQ0LBfrEDno3EH5-nsfs5sfF7_NfxdX1z8vz9VXhS2lVYRBM32vra22ER2GlbMH5VmljoZVorBPOo7NVi6aHynoB4MBo2_etQgnH7HSfu0nxYYs0N2Mgj8PgJoxbapS2CoQ1qs706yt6H7cp35tVrXWZ6yshq2975VMkStg3mxRGl5ZGiuZf703uvXnqPduT58RtO2L3X74UncHZHuzCgMvbSc3198t95CO5nIz8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2755408243</pqid></control><display><type>article</type><title>Association between chronic kidney disease and periodontitis. A systematic review and metanalysis</title><source>Access via Wiley Online Library</source><source>MEDLINE</source><creator>Serni, Lapo ; Caroti, Leonardo ; Barbato, Luigi ; Nieri, Michele ; Serni, Sergio ; Cirami, Calogero Lino ; Cairo, Francesco</creator><creatorcontrib>Serni, Lapo ; Caroti, Leonardo ; Barbato, Luigi ; Nieri, Michele ; Serni, Sergio ; Cirami, Calogero Lino ; Cairo, Francesco</creatorcontrib><description>Objectives
Aims of this SR were to assess the association of Periodontitis (PD) with Chronic Kidney Disease (CKD) and with different CKD stages.
Materials and methods
MEDLINE, Cochrane Central Register of Trials and EMBASE, up to April 4, 2021 were searched. RCTs, prospective and retrospective cohort studies, case–control studies and cross‐sectional studies were considered. JBI’s Critical Appraisal Tool for risk of bias assessment was used. The risk of PD was calculated using the Mantel–Haenszel odds ratios (MH‐OR); weighted mean difference for clinical attachment level (CAL) and periodontal probing depth (PPD) were also evaluated.
Results
Out of 1949 titles screened, 142 full texts were evaluated and 17 studies were included. CKD was associated to higher risk of PD (MH‐OR = 2.36, [95% C.I. 1.25, 4.44]; p = 0.008), higher mean CAL (WMD = 0.41 mm [95% C.I. 0.22, 0.60]; p < 0.0001) and mean PPD (WMD = 0.25 mm [95% C.I. 0.03, 0.47]; p = 0.02) compared to healthy individuals. Severe CKD (stages 4–5 vs 2–3) resulted at higher risk of PD (MH‐OR = 2.21, [95% C.I. 1.07, 4.54]; p = 0.03). Heterogeneity and risk of bias were high.
Conclusions
An association between PD and CKD was found. It could be appropriate to consider PD a frequent CKD comorbidity.</description><identifier>ISSN: 1354-523X</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/odi.14062</identifier><identifier>PMID: 34726333</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>chronic kidney disease ; chronic kidney failure ; Chronic Periodontitis - complications ; Clinical trials ; Comorbidity ; Cross-Sectional Studies ; Gum disease ; Humans ; Kidney diseases ; periodontal disease ; Periodontitis ; Periodontitis - complications ; periomedicine ; Prospective Studies ; Renal Insufficiency, Chronic - complications ; Renal Insufficiency, Chronic - epidemiology ; Retrospective Studies ; Systematic review</subject><ispartof>Oral diseases, 2023-01, Vol.29 (1), p.40-50</ispartof><rights>2021 Wiley Periodicals LLC</rights><rights>2021 Wiley Periodicals LLC.</rights><rights>2023 Wiley Periodicals LLC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4192-8e38ff59c7580ce0911b3acb25893b1e89a0acea96be8f369c033a3859ffb2e13</citedby><cites>FETCH-LOGICAL-c4192-8e38ff59c7580ce0911b3acb25893b1e89a0acea96be8f369c033a3859ffb2e13</cites><orcidid>0000-0002-0612-3517 ; 0000-0002-0524-7980 ; 0000-0001-8770-4622 ; 0000-0002-4499-4786 ; 0000-0003-3781-1715 ; 0000-0002-8699-985X ; 0000-0002-3776-4691</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fodi.14062$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fodi.14062$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27933,27934,45583,45584</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34726333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Serni, Lapo</creatorcontrib><creatorcontrib>Caroti, Leonardo</creatorcontrib><creatorcontrib>Barbato, Luigi</creatorcontrib><creatorcontrib>Nieri, Michele</creatorcontrib><creatorcontrib>Serni, Sergio</creatorcontrib><creatorcontrib>Cirami, Calogero Lino</creatorcontrib><creatorcontrib>Cairo, Francesco</creatorcontrib><title>Association between chronic kidney disease and periodontitis. A systematic review and metanalysis</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description>Objectives
Aims of this SR were to assess the association of Periodontitis (PD) with Chronic Kidney Disease (CKD) and with different CKD stages.
Materials and methods
MEDLINE, Cochrane Central Register of Trials and EMBASE, up to April 4, 2021 were searched. RCTs, prospective and retrospective cohort studies, case–control studies and cross‐sectional studies were considered. JBI’s Critical Appraisal Tool for risk of bias assessment was used. The risk of PD was calculated using the Mantel–Haenszel odds ratios (MH‐OR); weighted mean difference for clinical attachment level (CAL) and periodontal probing depth (PPD) were also evaluated.
Results
Out of 1949 titles screened, 142 full texts were evaluated and 17 studies were included. CKD was associated to higher risk of PD (MH‐OR = 2.36, [95% C.I. 1.25, 4.44]; p = 0.008), higher mean CAL (WMD = 0.41 mm [95% C.I. 0.22, 0.60]; p < 0.0001) and mean PPD (WMD = 0.25 mm [95% C.I. 0.03, 0.47]; p = 0.02) compared to healthy individuals. Severe CKD (stages 4–5 vs 2–3) resulted at higher risk of PD (MH‐OR = 2.21, [95% C.I. 1.07, 4.54]; p = 0.03). Heterogeneity and risk of bias were high.
Conclusions
An association between PD and CKD was found. It could be appropriate to consider PD a frequent CKD comorbidity.</description><subject>chronic kidney disease</subject><subject>chronic kidney failure</subject><subject>Chronic Periodontitis - complications</subject><subject>Clinical trials</subject><subject>Comorbidity</subject><subject>Cross-Sectional Studies</subject><subject>Gum disease</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>periodontal disease</subject><subject>Periodontitis</subject><subject>Periodontitis - complications</subject><subject>periomedicine</subject><subject>Prospective Studies</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Renal Insufficiency, Chronic - epidemiology</subject><subject>Retrospective Studies</subject><subject>Systematic review</subject><issn>1354-523X</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MFO3DAQBmCrKiqU9tAXQJZ6oYcstidO7OOK0hYJiUuRuEWOMxGmSbx4sl3l7XFZ6AEJX8aHb36Nfsa-SLGS-Z3FLqxkKSr1jh3JSshCGKXf5z_ostAKbg_ZR6J7IWRtQX1gh1DWqgKAI-bWRNEHN4c48RbnHeLE_V2KU_D8T-gmXHgXCB0hd1PHN5hC7OI0hznQiq85LTTjmPc9T_g34O6JjTi7yQ0LBfrEDno3EH5-nsfs5sfF7_NfxdX1z8vz9VXhS2lVYRBM32vra22ER2GlbMH5VmljoZVorBPOo7NVi6aHynoB4MBo2_etQgnH7HSfu0nxYYs0N2Mgj8PgJoxbapS2CoQ1qs706yt6H7cp35tVrXWZ6yshq2975VMkStg3mxRGl5ZGiuZf703uvXnqPduT58RtO2L3X74UncHZHuzCgMvbSc3198t95CO5nIz8</recordid><startdate>202301</startdate><enddate>202301</enddate><creator>Serni, Lapo</creator><creator>Caroti, Leonardo</creator><creator>Barbato, Luigi</creator><creator>Nieri, Michele</creator><creator>Serni, Sergio</creator><creator>Cirami, Calogero Lino</creator><creator>Cairo, Francesco</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0612-3517</orcidid><orcidid>https://orcid.org/0000-0002-0524-7980</orcidid><orcidid>https://orcid.org/0000-0001-8770-4622</orcidid><orcidid>https://orcid.org/0000-0002-4499-4786</orcidid><orcidid>https://orcid.org/0000-0003-3781-1715</orcidid><orcidid>https://orcid.org/0000-0002-8699-985X</orcidid><orcidid>https://orcid.org/0000-0002-3776-4691</orcidid></search><sort><creationdate>202301</creationdate><title>Association between chronic kidney disease and periodontitis. A systematic review and metanalysis</title><author>Serni, Lapo ; Caroti, Leonardo ; Barbato, Luigi ; Nieri, Michele ; Serni, Sergio ; Cirami, Calogero Lino ; Cairo, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4192-8e38ff59c7580ce0911b3acb25893b1e89a0acea96be8f369c033a3859ffb2e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>chronic kidney disease</topic><topic>chronic kidney failure</topic><topic>Chronic Periodontitis - complications</topic><topic>Clinical trials</topic><topic>Comorbidity</topic><topic>Cross-Sectional Studies</topic><topic>Gum disease</topic><topic>Humans</topic><topic>Kidney diseases</topic><topic>periodontal disease</topic><topic>Periodontitis</topic><topic>Periodontitis - complications</topic><topic>periomedicine</topic><topic>Prospective Studies</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>Renal Insufficiency, Chronic - epidemiology</topic><topic>Retrospective Studies</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serni, Lapo</creatorcontrib><creatorcontrib>Caroti, Leonardo</creatorcontrib><creatorcontrib>Barbato, Luigi</creatorcontrib><creatorcontrib>Nieri, Michele</creatorcontrib><creatorcontrib>Serni, Sergio</creatorcontrib><creatorcontrib>Cirami, Calogero Lino</creatorcontrib><creatorcontrib>Cairo, Francesco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serni, Lapo</au><au>Caroti, Leonardo</au><au>Barbato, Luigi</au><au>Nieri, Michele</au><au>Serni, Sergio</au><au>Cirami, Calogero Lino</au><au>Cairo, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between chronic kidney disease and periodontitis. A systematic review and metanalysis</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2023-01</date><risdate>2023</risdate><volume>29</volume><issue>1</issue><spage>40</spage><epage>50</epage><pages>40-50</pages><issn>1354-523X</issn><eissn>1601-0825</eissn><abstract>Objectives
Aims of this SR were to assess the association of Periodontitis (PD) with Chronic Kidney Disease (CKD) and with different CKD stages.
Materials and methods
MEDLINE, Cochrane Central Register of Trials and EMBASE, up to April 4, 2021 were searched. RCTs, prospective and retrospective cohort studies, case–control studies and cross‐sectional studies were considered. JBI’s Critical Appraisal Tool for risk of bias assessment was used. The risk of PD was calculated using the Mantel–Haenszel odds ratios (MH‐OR); weighted mean difference for clinical attachment level (CAL) and periodontal probing depth (PPD) were also evaluated.
Results
Out of 1949 titles screened, 142 full texts were evaluated and 17 studies were included. CKD was associated to higher risk of PD (MH‐OR = 2.36, [95% C.I. 1.25, 4.44]; p = 0.008), higher mean CAL (WMD = 0.41 mm [95% C.I. 0.22, 0.60]; p < 0.0001) and mean PPD (WMD = 0.25 mm [95% C.I. 0.03, 0.47]; p = 0.02) compared to healthy individuals. Severe CKD (stages 4–5 vs 2–3) resulted at higher risk of PD (MH‐OR = 2.21, [95% C.I. 1.07, 4.54]; p = 0.03). Heterogeneity and risk of bias were high.
Conclusions
An association between PD and CKD was found. It could be appropriate to consider PD a frequent CKD comorbidity.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34726333</pmid><doi>10.1111/odi.14062</doi><tpages>0</tpages><orcidid>https://orcid.org/0000-0002-0612-3517</orcidid><orcidid>https://orcid.org/0000-0002-0524-7980</orcidid><orcidid>https://orcid.org/0000-0001-8770-4622</orcidid><orcidid>https://orcid.org/0000-0002-4499-4786</orcidid><orcidid>https://orcid.org/0000-0003-3781-1715</orcidid><orcidid>https://orcid.org/0000-0002-8699-985X</orcidid><orcidid>https://orcid.org/0000-0002-3776-4691</orcidid></addata></record> |
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| subjects | chronic kidney disease chronic kidney failure Chronic Periodontitis - complications Clinical trials Comorbidity Cross-Sectional Studies Gum disease Humans Kidney diseases periodontal disease Periodontitis Periodontitis - complications periomedicine Prospective Studies Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - epidemiology Retrospective Studies Systematic review |
| title | Association between chronic kidney disease and periodontitis. A systematic review and metanalysis |
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