Imbalanced GSH/ROS and sequential cell death

Reactive oxygen species (ROS) are produced in cells during metabolic processes. Excessive intracellular ROS may react with large biomolecules, such as DNA, RNA, proteins, and small biomolecules, that is, glutathione (GSH) and unsaturated fatty acids. GSH has physiological functions, including free r...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2022-01, Vol.36 (1), p.e22942-n/a
Hauptverfasser:	Liu, Ting, Sun, Li, Zhang, Yubin, Wang, Yonglin, Zheng, Jiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Arsenic Arsenic trioxide Biomolecules Cell Cycle Checkpoints Cell Death Chemical activity Chemical modification Disruption Fatty acids Free radicals Glutathione Glutathione - metabolism GSH Humans Intracellular Mortality Oxidation Oxidoreductase Pyrogallol Reactive oxygen species Reactive Oxygen Species - metabolism redox balance ROS Scavenging stress signaling pathways Thioredoxin Thioredoxins - metabolism
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