Review of -omics studies on mosquito-borne viruses of the Flavivirus genus

•Mosquito-transmitted arboviruses studied by omics tools and technology enable a better understanding of the virus infection.•Omics approach (genomics, transcriptomics, proteomics, and metabolomics) bring a deep view of the virus-mosquito-host interaction.•The study integration of genes, transcripts, proteins, and metabolites provide a perspective between host and virus.•The identification of host cell pathways commonly used by members of the Flaviviridae family by omics studies might help in the development of broad-spectrum antiviral drugs that target multiple members of this family. Arboviruses are transmitted by arthropods (arthropod-borne virus) which can be mosquitoes or other hematophagous arthropods, in which their life cycle occurs before transmission to other hosts. Arboviruses such as Dengue, Zika, Saint Louis Encephalitis, West Nile, Yellow Fever, Japanese Encephalitis, Rocio and Murray Valley Encephalitis viruses are some of the arboviruses transmitted biologically among vertebrate hosts by blood-taking vectors, mainly Aedes and Culex sp., and are associated with neurological, viscerotropic, and hemorrhagic reemerging diseases, posing as significant health and socioeconomic concern, as they become more and more adaptive to new environments, to arthropods vectors and human hosts. One of the main families that include mosquito-borne viruses is Flaviviridae, and here, we review the case of the Flavivirus genus, which comprises the viruses cited above, using a variety of research approaches published in literature, including genomics, transcriptomics, proteomics, metabolomics, etc., to better understand their structures as well as virus-host interactions, which are essential for development of future antiviral therapies.