A Novel Function of Sphingosylphosphorylcholine on the Inhibitory Effects of Acetylcholinesterase Activity

Acetylcholine (ACh), a quaternary ammonium cation, is known as one of the itch inducer in atopic dermatitis (AD), an inflammatory skin disease with intense itching. Previous research has reported accumulation of ACh in lesional site of AD patients. Generally, ACh is metabolized by cholinesterase (Ch...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2021/11/01, Vol.44(11), pp.1717-1723
Hauptverfasser:	Kitazawa, Kazuyuki, Nagasawa-Shimura, Nanako, Tanaka, Kazunori, Musashi, Mina, Kubota, Yoshiki, Nagasawa, Teruaki, Yamaguchi, Yoko
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine Acetylcholinesterase Acetylcholinesterase - metabolism acetylcholinesterase inhibitor Ammonium Atopic dermatitis Cholinesterase Inhibitors - pharmacology Dose-Response Relationship, Drug Eczema Humans Neostigmine - pharmacology Phosphorylcholine - analogs & derivatives Phosphorylcholine - pharmacology Pruritus quaternary ammonium cation Rivastigmine - pharmacology Skin diseases sphingolipid Sphingolipids Sphingosine - analogs & derivatives Sphingosine - pharmacology Sphingosylphosphorylcholine
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