Functional Interaction between Cytochrome P450 and UDP-Glucuronosyltransferase on the Endoplasmic Reticulum Membrane: One of Post-translational Factors Which Possibly Contributes to Their Inter-Individual Differences

Cytochrome P450 (P450) and uridine 5′-diphosphate (UDP)-glucuronosyltransferase (UGT) catalyze oxidation and glucuronidation in drug metabolism, respectively. It is believed that P450 and UGT work separately because they perform distinct reactions and exhibit opposite membrane topologies on the endo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biological & pharmaceutical bulletin 2021/11/01, Vol.44(11), pp.1635-1644
Hauptverfasser:	Miyauchi, Yuu, Takechi, Shinji, Ishii, Yuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Column chromatography Cytochrome Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Drug metabolism Endoplasmic reticulum Endoplasmic Reticulum - enzymology Endoplasmic Reticulum - metabolism Enzymes Glucuronosyltransferase Glucuronosyltransferase - metabolism Humans Hydrophobicity Individuality inter-individual difference Intracellular Membranes - enzymology Intracellular Membranes - metabolism Microsomes Oxidation Post-translation Protein interaction Protein Interaction Domains and Motifs Protein Processing, Post-Translational Proteins protein–protein interaction Translation UDP-glucuronosyltransferase Uridine uridine 5′-diphosphate-glucuronosyltransferase
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!