Torsadogenic Potential of HCN Channel Blocker Ivabradine Assessed in the Rabbit Proarrhythmia Model

Torsadogenic effects of ivabradine, an inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, were assessed in an in vivo proarrhythmia model of acute atrioventricular block rabbit. Ivabradine at 0.01, 0.1, and 1 mg/kg was intravenously administered to isoflurane-anesthetiz...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2021/11/01, Vol.44(11), pp.1796-1799
Hauptverfasser:	Takahara, Akira, Kawakami, Satoshi, Aimoto, Megumi, Nagasawa, Yoshinobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Animals Atrioventricular Block - drug therapy Automation Cardiac arrhythmia Cardiovascular Agents - adverse effects Cardiovascular Agents - pharmacology Cardiovascular Agents - therapeutic use Disease Models, Animal Electrocardiography Heart Heart Rate - drug effects Hemodynamics Hyperpolarization Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - antagonists & inhibitors Isoflurane ivabradine Ivabradine - adverse effects Ivabradine - pharmacology Ivabradine - therapeutic use Male QT-interval prolongation Rabbits torsade de pointes Torsades de pointes Torsades de Pointes - chemically induced Ventricle
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