Novel Biodegradable Zn Alloy with Exceptional Mechanical and In Vitro Corrosion Properties for Biomedical Applications

A series of quaternary Zn-Al-Cu-Li alloys with different weight fractions of Cu, Al, and Li were developed and investigated for potential application in high load bearing bioresorbable implants. The developed alloys provided various fractions of binary and ternary intermetallic structures, which res...

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Veröffentlicht in:ACS biomaterials science & engineering 2021-12, Vol.7 (12), p.5555-5572
Hauptverfasser: Farabi, Ehsan, Sharp, Julie, Vahid, Alireza, Wang, Jiangting, Fabijanic, Daniel M, Barnett, Matthew R, Corujeira Gallo, Santiago
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container_issue 12
container_start_page 5555
container_title ACS biomaterials science & engineering
container_volume 7
creator Farabi, Ehsan
Sharp, Julie
Vahid, Alireza
Wang, Jiangting
Fabijanic, Daniel M
Barnett, Matthew R
Corujeira Gallo, Santiago
description A series of quaternary Zn-Al-Cu-Li alloys with different weight fractions of Cu, Al, and Li were developed and investigated for potential application in high load bearing bioresorbable implants. The developed alloys provided various fractions of binary and ternary intermetallic structures, which resulted in formation of multiphase microstructures containing a zinc-rich η-phase and LiZn4 and CuZn4 phases. The intermetallic phases promoted grain refinement and a good combination of mechanical properties. The developed Zn-2Al-4Cu-0.6Li alloy showed strength and ductility close to commercially pure Ti alloys with a UTS value of ∼535 MPa and elongation of 37%. The examination of in vitro corrosion behavior of the developed alloys in the modified Hanks’ solution revealed suitable corrosion rates (∼38.5 μm/year). The moderate corrosion rate was controlled by the formation of a homogeneous layer of stable corrosion products that protected the alloys from the corrosive environment, particularly in the late stages of immersion. The developed alloys with the most promising mechanical and corrosion properties appeared to be biocompatible to mouse fibroblast cells and human umbilical mesenchymal stem cells, making them suitable candidates for implant applications.
doi_str_mv 10.1021/acsbiomaterials.1c00763
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subjects Alloys
Animals
Bio-interactions and Biocompatibility
Corrosion
Materials Testing
Mice
Tensile Strength
Zinc
title Novel Biodegradable Zn Alloy with Exceptional Mechanical and In Vitro Corrosion Properties for Biomedical Applications
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