DNA damage and aging on hematopoietic stem cells: Impact of oxidative stress in ApoE−/− mice

The effects of aging on ROS production and DNA damage were assessed in hematopoietic stem cells (HSCs) from apolipoprotein E–deficient (ApoE−/−) mice (2-, 12- and 24-month-old), a traditional experimental model of atherogenic dyslipidemia. HSCs from aged ApoE−/− mice were associated with increased R...

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Veröffentlicht in:	Experimental gerontology 2021-12, Vol.156, p.111607-111607, Article 111607
Hauptverfasser:	Aires, R., Porto, M.L., de Assis, L.M., Pereira, P.A.N., Carvalho, G.R., Côco, L.Z., Vasquez, E.C., Pereira, T.M.C., Campagnaro, B.P., Meyrelles, S.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Apolipoproteins E - genetics Atherosclerosis Cell cycle Cellular Senescence DNA Damage Hematopoietic Stem Cells Mice Mice, Inbred C57BL Oxidative Stress Reactive Oxygen Species Telomere
Online-Zugang:	Volltext
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