Sulbactam improves binding property and uptake capacity of glutamate transporter-1 and decreases glutamate concentration in the CA1 region of hippocampus of global brain ischemic rats

Glutamate transporter-1 (GLT-1) removes most glutamate in the synaptic cleft. Sulbactam confers neuronal protection against ischemic insults in the hippocampal CA1 region accompanied by the upregulation of GLT-1 expression in rats. The present study further investigates the effect of sulbactam on th...

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Veröffentlicht in:	Amino acids 2021-11, Vol.53 (11), p.1649-1661
Hauptverfasser:	Gu, Wei-Wei, Cui, Xin, Liu, Li-Zhe, Zhang, Min, Li, Wen-Bin, Xian, Xiao-Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical Chemistry Animals Antisense oligonucleotides Binding Biochemical Engineering Biochemistry Biological Transport - drug effects Biomedical and Life Sciences Brain Brain Ischemia - drug therapy Brain Ischemia - genetics Brain Ischemia - metabolism CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - metabolism Excitatory Amino Acid Transporter 2 - genetics Excitatory Amino Acid Transporter 2 - metabolism Excitotoxicity Glutamic Acid - metabolism Glutamic acid transporter High performance liquid chromatography Hippocampus Humans Ischemia Life Sciences Male Mass spectrometry Mass spectroscopy Microdialysis Neurobiology Neurons - drug effects Neurons - metabolism Neuroprotection Original Article Protein Binding - drug effects Proteomics Rats Rats, Wistar Sulbactam Sulbactam - administration & dosage Synaptic cleft
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