Mycobacterium tuberculosis ESAT6 modulates host innate immunity by downregulating miR-222-3p target PTEN

Tuberculosis (TB) remains a major cause of mortality and morbidity worldwide, and it is instant to discover novel anti-TB drugs due to the rapidly growing drug-resistance TB. Mycobacterium tuberculosis (Mtb) secreted effector ESAT6 plays a critical role in modulation miRNAs to regulate host defense...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2022-01, Vol.1868 (1), p.166292-166292, Article 166292
Hauptverfasser:	Zonghai, Chen, Tao, Luo, Pengjiao, Ma, Liang, Ge, Rongchuan, Zhao, Xinyan, Wang, Wenyi, Ni, Wei, Liao, Yi, Wang, Lang, Bao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Bacterial - genetics Bacterial Proteins - genetics Disease Models, Animal ESAT6 Host-Pathogen Interactions - genetics Humans Immunity, Innate - genetics Innate Immunnity Mice MicroRNAs - genetics MiR-222-3p Mycobacterium smegmatis - genetics Mycobacterium smegmatis - pathogenicity Mycobacterium Tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - pathogenicity PTEN PTEN Phosphohydrolase - genetics Tuberculosis - genetics Tuberculosis - immunology Tuberculosis - pathology VO-Ohpic trihydrate
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