Inhibition of monoamine oxidase B prevents reactive astrogliosis and scar formation in stab wound injury model

Reactive astrocytes manifest molecular, structural, and functional alterations under various pathological conditions. We have previously demonstrated that the reactive astrocytes of the stab wound injury model (STAB) display aberrant cellular gamma‐aminobutyric acid (GABA) content and tonic GABA rel...

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Veröffentlicht in:	Glia 2022-02, Vol.70 (2), p.354-367
Hauptverfasser:	Chun, Heejung, Lim, Jiwoon, Park, Ki Duk, Lee, C. Justin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amine oxidase (flavin-containing) Astrocytes Astrocytes - metabolism Brain injury Cicatrix - metabolism Cicatrix - pathology Cicatrix - prevention & control Enrichment Glial fibrillary acidic protein Glial Fibrillary Acidic Protein - metabolism glial scar Gliosis Gliosis - metabolism H2O2 Head injuries Humans Hydrogen peroxide Hypertrophy Injury prevention MAO‐B Monoamine Oxidase - genetics Monoamine Oxidase - metabolism Monoamine Oxidase - pharmacology Oxidase reactive astrocytes Structure-function relationships Therapeutic targets Wounds Wounds, Stab - pathology γ-Aminobutyric acid
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