Characterisation and heterologous biosynthesis of burnettiene A, a new polyene-decalin polyketide from Aspergillus burnettii

Chemical exploration of the recently described Australian fungus, , uncovered a new metabolite, burnettiene A. Here, we characterise the structure of burnettiene A as a polyene-decalin polyketide. Bioinformatic analysis of the genome of identified a putative biosynthetic gene cluster for burnettiene...

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Veröffentlicht in:	Organic & biomolecular chemistry 2021-11, Vol.19 (43), p.9506-9513
Hauptverfasser:	Roux, Indra, Bowles, Simon, Kalaitzis, John A, Vuong, Daniel, Lacey, Ernest, Chooi, Yit-Heng, Piggott, Andrew M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Aspergillus Aspergillus - chemistry Aspergillus - metabolism Biosynthesis Carboxylic acids Cell Line, Tumor Cytochrome Cytochrome P450 Cytochromes P450 Cytotoxicity Decalin Genomes Humans Metabolites Methyltransferase Molecular Structure Multigene Family Myeloma Naphthalenes - chemistry Naphthalenes - metabolism Oxidation Polyenes - chemistry Polyenes - metabolism Polyketides - chemistry Polyketides - metabolism Toxicity
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