Mechanical stimulus-evoked signal transduction between keratinocytes and sensory neurons via extracellular ATP

The skin is exposed to various external stimuli. Keratinocytes, which are the main cell type in the epidermis, interact with peripheral sensory neurons and modulate neuronal activity. Recent studies have revealed that keratinocytes play crucial roles in nociception, and that ATP is one of the main m...

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Veröffentlicht in:	Biochemical and biophysical research communications 2021-12, Vol.582, p.131-136
Hauptverfasser:	Shindo, Yutaka, Fujita, Keigo, Tanaka, Mari, Fujio, Hiroki, Hotta, Kohji, Oka, Kotaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Adenosine Triphosphate - pharmacology Animals ATP release Benzofurans - analysis Benzofurans - chemistry Ca2+ imaging Calcium - metabolism Cations, Divalent Cell Membrane - drug effects Cell Membrane - metabolism Coculture Techniques DRG neurons Epidermis Epidermis - innervation Epidermis - metabolism Ganglia, Spinal - cytology Ganglia, Spinal - metabolism Genes, Reporter Humans iATPSnFR Imidazoles - analysis Imidazoles - chemistry Infant, Newborn Keratinocytes - cytology Keratinocytes - drug effects Keratinocytes - metabolism Mechanical stimulus Mechanotransduction, Cellular Molecular Probes - analysis Molecular Probes - chemistry Nociception - physiology Rats Rats, Wistar Sensory Receptor Cells - cytology Sensory Receptor Cells - drug effects Sensory Receptor Cells - metabolism Time-Lapse Imaging
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