Differential expression and interaction of melatonin and thyroid hormone receptors with estrogen receptor α improve ovarian functions in letrozole-induced rat polycystic ovary syndrome
The objective of the present study was to investigate the effect of melatonin and L-thyroxine (T4) on the expression of various receptors, and some metabolic, reproductive, and gonadotropic hormones in letrozole-induced polycystic ovary syndrome (PCOS) in rats. Assessment of gravimetric, hormonal pr...
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| Veröffentlicht in: | Life sciences (1973) 2022-04, Vol.295, p.120086-120086, Article 120086 |
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| container_title | Life sciences (1973) |
| container_volume | 295 |
| creator | Ghosh, Hindole Rai, Seema Manzar, Md Dilshad Pandi-Perumal, Seithikurippu R. Brown, Gregory M. Reiter, Russel J. Cardinali, Daniel P. |
| description | The objective of the present study was to investigate the effect of melatonin and L-thyroxine (T4) on the expression of various receptors, and some metabolic, reproductive, and gonadotropic hormones in letrozole-induced polycystic ovary syndrome (PCOS) in rats.
Assessment of gravimetric, hormonal profile and thyroid histology and relative expression of melatonin receptors (MT1, MT2) and estrogen receptor α (Erα) in thyroid and ovary, and type II iodothyronine deiodinase (Dio2) and thyroid hormone receptor α (TRα) in the ovary were performed using standard protocols.
A significant increase in thyroid follicles numbers was noted in the hyperthyroid rat. T4 treatment to PCOS showed the expected increment in the circulating level of triiodothyronine (T3) and T4. Melatonin and T4 treatment of PCOS rats resulted in a significant decrease in the circulating level of T3 and T4. Hyperthyroid rats showed a decrement in plasma melatonin levels. However, T4 treatment to PCOS rats showed increased circulating melatonin levels, and a decrease in the circulating level of gonadotropins (LH and FSH), and testosterone. Melatonin treatment to PCOS-hyperthyroid rats resulted in the normal expression of ovarian and thyroid MT1 and ERα, receptors, which had been altered in PCOS and hyperthyroid rats, without any significant change in the MT2 receptor.
The present findings suggest a fine interplay and cross-talk via melatonin and its two receptors with ERα, TRα, and Dio2in thyroid and ovarian tissue during PCOS and hyperthyroidism pathogenicity. |
| doi_str_mv | 10.1016/j.lfs.2021.120086 |
| format | Article |
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Assessment of gravimetric, hormonal profile and thyroid histology and relative expression of melatonin receptors (MT1, MT2) and estrogen receptor α (Erα) in thyroid and ovary, and type II iodothyronine deiodinase (Dio2) and thyroid hormone receptor α (TRα) in the ovary were performed using standard protocols.
A significant increase in thyroid follicles numbers was noted in the hyperthyroid rat. T4 treatment to PCOS showed the expected increment in the circulating level of triiodothyronine (T3) and T4. Melatonin and T4 treatment of PCOS rats resulted in a significant decrease in the circulating level of T3 and T4. Hyperthyroid rats showed a decrement in plasma melatonin levels. However, T4 treatment to PCOS rats showed increased circulating melatonin levels, and a decrease in the circulating level of gonadotropins (LH and FSH), and testosterone. Melatonin treatment to PCOS-hyperthyroid rats resulted in the normal expression of ovarian and thyroid MT1 and ERα, receptors, which had been altered in PCOS and hyperthyroid rats, without any significant change in the MT2 receptor.
The present findings suggest a fine interplay and cross-talk via melatonin and its two receptors with ERα, TRα, and Dio2in thyroid and ovarian tissue during PCOS and hyperthyroidism pathogenicity.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2021.120086</identifier><identifier>PMID: 34710445</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Disease Models, Animal ; Estrogen Receptor alpha - metabolism ; Estrogen Receptor alpha - physiology ; Female ; Gene Expression - genetics ; Gene Expression Regulation - drug effects ; Gene Expression Regulation - genetics ; Gonadotropins - metabolism ; Hyperthyroid ; Hyperthyroidism - metabolism ; Hypothyroid ; Letrozole - pharmacology ; Melatonin ; Melatonin - metabolism ; Melatonin - pharmacology ; Ovary - metabolism ; Ovary - physiology ; PCOS ; Polycystic Ovary Syndrome - genetics ; Polycystic Ovary Syndrome - metabolism ; Polycystic Ovary Syndrome - pathology ; Rats ; Rats, Wistar ; Receptors, Thyroid Hormone - metabolism ; Receptors, Thyroid Hormone - physiology ; Testosterone - metabolism ; Thyroid Gland - drug effects ; Thyroid Hormones - metabolism ; Thyroxine ; Thyroxine - metabolism</subject><ispartof>Life sciences (1973), 2022-04, Vol.295, p.120086-120086, Article 120086</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-1695da6d60097356c675b48d5b949210e8bc0d08f665e17825270a7f6e62e63e3</citedby><cites>FETCH-LOGICAL-c353t-1695da6d60097356c675b48d5b949210e8bc0d08f665e17825270a7f6e62e63e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.lfs.2021.120086$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34710445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghosh, Hindole</creatorcontrib><creatorcontrib>Rai, Seema</creatorcontrib><creatorcontrib>Manzar, Md Dilshad</creatorcontrib><creatorcontrib>Pandi-Perumal, Seithikurippu R.</creatorcontrib><creatorcontrib>Brown, Gregory M.</creatorcontrib><creatorcontrib>Reiter, Russel J.</creatorcontrib><creatorcontrib>Cardinali, Daniel P.</creatorcontrib><title>Differential expression and interaction of melatonin and thyroid hormone receptors with estrogen receptor α improve ovarian functions in letrozole-induced rat polycystic ovary syndrome</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>The objective of the present study was to investigate the effect of melatonin and L-thyroxine (T4) on the expression of various receptors, and some metabolic, reproductive, and gonadotropic hormones in letrozole-induced polycystic ovary syndrome (PCOS) in rats.
Assessment of gravimetric, hormonal profile and thyroid histology and relative expression of melatonin receptors (MT1, MT2) and estrogen receptor α (Erα) in thyroid and ovary, and type II iodothyronine deiodinase (Dio2) and thyroid hormone receptor α (TRα) in the ovary were performed using standard protocols.
A significant increase in thyroid follicles numbers was noted in the hyperthyroid rat. T4 treatment to PCOS showed the expected increment in the circulating level of triiodothyronine (T3) and T4. Melatonin and T4 treatment of PCOS rats resulted in a significant decrease in the circulating level of T3 and T4. Hyperthyroid rats showed a decrement in plasma melatonin levels. However, T4 treatment to PCOS rats showed increased circulating melatonin levels, and a decrease in the circulating level of gonadotropins (LH and FSH), and testosterone. Melatonin treatment to PCOS-hyperthyroid rats resulted in the normal expression of ovarian and thyroid MT1 and ERα, receptors, which had been altered in PCOS and hyperthyroid rats, without any significant change in the MT2 receptor.
The present findings suggest a fine interplay and cross-talk via melatonin and its two receptors with ERα, TRα, and Dio2in thyroid and ovarian tissue during PCOS and hyperthyroidism pathogenicity.</description><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>Estrogen Receptor alpha - metabolism</subject><subject>Estrogen Receptor alpha - physiology</subject><subject>Female</subject><subject>Gene Expression - genetics</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Gene Expression Regulation - genetics</subject><subject>Gonadotropins - metabolism</subject><subject>Hyperthyroid</subject><subject>Hyperthyroidism - metabolism</subject><subject>Hypothyroid</subject><subject>Letrozole - pharmacology</subject><subject>Melatonin</subject><subject>Melatonin - metabolism</subject><subject>Melatonin - pharmacology</subject><subject>Ovary - metabolism</subject><subject>Ovary - physiology</subject><subject>PCOS</subject><subject>Polycystic Ovary Syndrome - genetics</subject><subject>Polycystic Ovary Syndrome - metabolism</subject><subject>Polycystic Ovary Syndrome - pathology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Thyroid Hormone - metabolism</subject><subject>Receptors, Thyroid Hormone - physiology</subject><subject>Testosterone - metabolism</subject><subject>Thyroid Gland - drug effects</subject><subject>Thyroid Hormones - metabolism</subject><subject>Thyroxine</subject><subject>Thyroxine - metabolism</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kb2O1DAUhSMEYoeFB6BBLmkyXNuxk4gKLb_SSjRQWx77hvEosYPtmSW8FSUvwTPh2SxbUlm2zzn356uq5xS2FKh8ddiOQ9oyYHRLGUAnH1Qb2rV9DZLTh9UGgDU1ZyAuqicpHQBAiJY_ri5401JoGrGpfr91w4ARfXZ6JPhjjpiSC55ob4nzGaM2-XwPA5lw1Dl4t37m_RKDs2Qf4hQ8kogG5xxiIjcu7wmmHMM39Pfv5M8v4qY5hhOScNLRaU-Go79NT6UUGbE4foYRa-ft0aAlUWcyh3ExS8rO3LoWkhZvY5jwafVo0GPCZ3fnZfX1_bsvVx_r688fPl29ua4NFzzXVPbCamklQN9yIY1sxa7prNj1Tc8oYLczYKEbpBRI244J1oJuB4mSoeTIL6uXa25p_fuxjKUmlwyOo_YYjkkx0ZfonktWpHSVmhhSijioObqpNK0oqDMxdVCFmDoTUyux4nlxF3_cTWjvHf8QFcHrVYBlyJPDqJJx6Mt-XFltVja4_8T_BQKbrJc</recordid><startdate>20220415</startdate><enddate>20220415</enddate><creator>Ghosh, Hindole</creator><creator>Rai, Seema</creator><creator>Manzar, Md Dilshad</creator><creator>Pandi-Perumal, Seithikurippu R.</creator><creator>Brown, Gregory M.</creator><creator>Reiter, Russel J.</creator><creator>Cardinali, Daniel P.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20220415</creationdate><title>Differential expression and interaction of melatonin and thyroid hormone receptors with estrogen receptor α improve ovarian functions in letrozole-induced rat polycystic ovary syndrome</title><author>Ghosh, Hindole ; Rai, Seema ; Manzar, Md Dilshad ; Pandi-Perumal, Seithikurippu R. ; Brown, Gregory M. ; Reiter, Russel J. ; Cardinali, Daniel P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-1695da6d60097356c675b48d5b949210e8bc0d08f665e17825270a7f6e62e63e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>Estrogen Receptor alpha - metabolism</topic><topic>Estrogen Receptor alpha - physiology</topic><topic>Female</topic><topic>Gene Expression - genetics</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Gene Expression Regulation - genetics</topic><topic>Gonadotropins - metabolism</topic><topic>Hyperthyroid</topic><topic>Hyperthyroidism - metabolism</topic><topic>Hypothyroid</topic><topic>Letrozole - pharmacology</topic><topic>Melatonin</topic><topic>Melatonin - metabolism</topic><topic>Melatonin - pharmacology</topic><topic>Ovary - metabolism</topic><topic>Ovary - physiology</topic><topic>PCOS</topic><topic>Polycystic Ovary Syndrome - genetics</topic><topic>Polycystic Ovary Syndrome - metabolism</topic><topic>Polycystic Ovary Syndrome - pathology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Thyroid Hormone - metabolism</topic><topic>Receptors, Thyroid Hormone - physiology</topic><topic>Testosterone - metabolism</topic><topic>Thyroid Gland - drug effects</topic><topic>Thyroid Hormones - metabolism</topic><topic>Thyroxine</topic><topic>Thyroxine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghosh, Hindole</creatorcontrib><creatorcontrib>Rai, Seema</creatorcontrib><creatorcontrib>Manzar, Md Dilshad</creatorcontrib><creatorcontrib>Pandi-Perumal, Seithikurippu R.</creatorcontrib><creatorcontrib>Brown, Gregory M.</creatorcontrib><creatorcontrib>Reiter, Russel J.</creatorcontrib><creatorcontrib>Cardinali, Daniel P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghosh, Hindole</au><au>Rai, Seema</au><au>Manzar, Md Dilshad</au><au>Pandi-Perumal, Seithikurippu R.</au><au>Brown, Gregory M.</au><au>Reiter, Russel J.</au><au>Cardinali, Daniel P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential expression and interaction of melatonin and thyroid hormone receptors with estrogen receptor α improve ovarian functions in letrozole-induced rat polycystic ovary syndrome</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2022-04-15</date><risdate>2022</risdate><volume>295</volume><spage>120086</spage><epage>120086</epage><pages>120086-120086</pages><artnum>120086</artnum><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>The objective of the present study was to investigate the effect of melatonin and L-thyroxine (T4) on the expression of various receptors, and some metabolic, reproductive, and gonadotropic hormones in letrozole-induced polycystic ovary syndrome (PCOS) in rats.
Assessment of gravimetric, hormonal profile and thyroid histology and relative expression of melatonin receptors (MT1, MT2) and estrogen receptor α (Erα) in thyroid and ovary, and type II iodothyronine deiodinase (Dio2) and thyroid hormone receptor α (TRα) in the ovary were performed using standard protocols.
A significant increase in thyroid follicles numbers was noted in the hyperthyroid rat. T4 treatment to PCOS showed the expected increment in the circulating level of triiodothyronine (T3) and T4. Melatonin and T4 treatment of PCOS rats resulted in a significant decrease in the circulating level of T3 and T4. Hyperthyroid rats showed a decrement in plasma melatonin levels. However, T4 treatment to PCOS rats showed increased circulating melatonin levels, and a decrease in the circulating level of gonadotropins (LH and FSH), and testosterone. Melatonin treatment to PCOS-hyperthyroid rats resulted in the normal expression of ovarian and thyroid MT1 and ERα, receptors, which had been altered in PCOS and hyperthyroid rats, without any significant change in the MT2 receptor.
The present findings suggest a fine interplay and cross-talk via melatonin and its two receptors with ERα, TRα, and Dio2in thyroid and ovarian tissue during PCOS and hyperthyroidism pathogenicity.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>34710445</pmid><doi>10.1016/j.lfs.2021.120086</doi><tpages>1</tpages></addata></record> |
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| ispartof | Life sciences (1973), 2022-04, Vol.295, p.120086-120086, Article 120086 |
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| subjects | Animals Disease Models, Animal Estrogen Receptor alpha - metabolism Estrogen Receptor alpha - physiology Female Gene Expression - genetics Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Gonadotropins - metabolism Hyperthyroid Hyperthyroidism - metabolism Hypothyroid Letrozole - pharmacology Melatonin Melatonin - metabolism Melatonin - pharmacology Ovary - metabolism Ovary - physiology PCOS Polycystic Ovary Syndrome - genetics Polycystic Ovary Syndrome - metabolism Polycystic Ovary Syndrome - pathology Rats Rats, Wistar Receptors, Thyroid Hormone - metabolism Receptors, Thyroid Hormone - physiology Testosterone - metabolism Thyroid Gland - drug effects Thyroid Hormones - metabolism Thyroxine Thyroxine - metabolism |
| title | Differential expression and interaction of melatonin and thyroid hormone receptors with estrogen receptor α improve ovarian functions in letrozole-induced rat polycystic ovary syndrome |
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