The neuroprotective effect and possible therapeutic application of xenon in neurological diseases
Xenon is an inert gas with stable chemical properties which is used as an anesthetic. Recent in vitro and in vivo findings indicate that xenon also elicits an excellent neuroprotective effect in subanesthetic concentrations. The mechanisms underlying this primarily involve the attenuation of excitot...
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| Veröffentlicht in: | Journal of neuroscience research 2021-12, Vol.99 (12), p.3274-3283 |
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| creator | Zhang, Mengdi Cui, Yaru Cheng, Yao Wang, Qiaoyun Sun, Hongliu |
| description | Xenon is an inert gas with stable chemical properties which is used as an anesthetic. Recent in vitro and in vivo findings indicate that xenon also elicits an excellent neuroprotective effect in subanesthetic concentrations. The mechanisms underlying this primarily involve the attenuation of excitotoxicity and the inhibition of N‐methyl‐d‐aspartic acid (NMDA) receptors and NMDA receptor‐related effects, such as antioxidative effects, reduced activation of microglia, and Ca2+‐dependent mechanisms, as well as the interaction with certain ion channels and glial cells. Based on this strong neuroprotective role, a large number of experimental and clinical studies have confirmed the significant therapeutic effect of xenon in the treatment of neurological diseases. This review summarizes the reported neuroprotective mechanisms of xenon and discusses its possible therapeutic application in the treatment of various neurological diseases. |
| doi_str_mv | 10.1002/jnr.24958 |
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Recent in vitro and in vivo findings indicate that xenon also elicits an excellent neuroprotective effect in subanesthetic concentrations. The mechanisms underlying this primarily involve the attenuation of excitotoxicity and the inhibition of N‐methyl‐d‐aspartic acid (NMDA) receptors and NMDA receptor‐related effects, such as antioxidative effects, reduced activation of microglia, and Ca2+‐dependent mechanisms, as well as the interaction with certain ion channels and glial cells. Based on this strong neuroprotective role, a large number of experimental and clinical studies have confirmed the significant therapeutic effect of xenon in the treatment of neurological diseases. 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Recent in vitro and in vivo findings indicate that xenon also elicits an excellent neuroprotective effect in subanesthetic concentrations. The mechanisms underlying this primarily involve the attenuation of excitotoxicity and the inhibition of N‐methyl‐d‐aspartic acid (NMDA) receptors and NMDA receptor‐related effects, such as antioxidative effects, reduced activation of microglia, and Ca2+‐dependent mechanisms, as well as the interaction with certain ion channels and glial cells. Based on this strong neuroprotective role, a large number of experimental and clinical studies have confirmed the significant therapeutic effect of xenon in the treatment of neurological diseases. This review summarizes the reported neuroprotective mechanisms of xenon and discusses its possible therapeutic application in the treatment of various neurological diseases.</description><subject>Anesthetics, Inhalation - pharmacology</subject><subject>Aspartic acid</subject><subject>Attenuation</subject><subject>Calcium ions</subject><subject>Chemical properties</subject><subject>Excitotoxicity</subject><subject>Glial cells</subject><subject>Glutamic acid receptors (ionotropic)</subject><subject>Health services</subject><subject>Ion channels</subject><subject>Microglia</subject><subject>N-Methyl-D-aspartic acid receptors</subject><subject>neurological disease</subject><subject>Neurological diseases</subject><subject>Neuronal-glial interactions</subject><subject>Neuroprotection</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>Rare gases</subject><subject>Receptors</subject><subject>Receptors, N-Methyl-D-Aspartate</subject><subject>Xenon</subject><subject>Xenon - pharmacology</subject><subject>Xenon - therapeutic use</subject><issn>0360-4012</issn><issn>1097-4547</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1P3DAQQC0E6i60B_4AssSlHLKM7diJjwhRPoSKhOjZcpJx8SqbBDuB7r-v22w5VOLkkfz0NPMIOWawYgD8fN2FFc-1LPfIkoEuslzmxT5ZglCQ5cD4ghzGuAYAraX4RBYiL5hSTC6JfXpG2uEU-iH0I9ajf0WKzqWJ2q6hQx-jr1qk4zMGO-A0-praYWh9bUffd7R39Bd2afDd7Gn7n-mvpY2PaCPGz-TA2Tbil917RH58u3q6vMnuH65vLy_us1pIUWaVU65xWgPmWnPBuFVYaV1qzrisRQNNWeuqURWidMiAOasqqSDnTcU4MHFEvs7edMjLhHE0Gx9rbFvbYT9Fw6UGKMtCQ0JP_0PX_RS6tJ3higmuy1wWiTqbqTqkCAGdGYLf2LA1DMyf7iZ1N3-7J_ZkZ5yqDTbv5L_QCTifgTff4vZjk7n7_jgrfwMgfo12</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Zhang, Mengdi</creator><creator>Cui, Yaru</creator><creator>Cheng, Yao</creator><creator>Wang, Qiaoyun</creator><creator>Sun, Hongliu</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4753-5219</orcidid></search><sort><creationdate>202112</creationdate><title>The neuroprotective effect and possible therapeutic application of xenon in neurological diseases</title><author>Zhang, Mengdi ; Cui, Yaru ; Cheng, Yao ; Wang, Qiaoyun ; Sun, Hongliu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3538-bf6fdf990e4992312a6eb99892125c3d0d8c9bd6bee5fe101fa6b56042db12013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anesthetics, Inhalation - pharmacology</topic><topic>Aspartic acid</topic><topic>Attenuation</topic><topic>Calcium ions</topic><topic>Chemical properties</topic><topic>Excitotoxicity</topic><topic>Glial cells</topic><topic>Glutamic acid receptors (ionotropic)</topic><topic>Health services</topic><topic>Ion channels</topic><topic>Microglia</topic><topic>N-Methyl-D-aspartic acid receptors</topic><topic>neurological disease</topic><topic>Neurological diseases</topic><topic>Neuronal-glial interactions</topic><topic>Neuroprotection</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>Rare gases</topic><topic>Receptors</topic><topic>Receptors, N-Methyl-D-Aspartate</topic><topic>Xenon</topic><topic>Xenon - pharmacology</topic><topic>Xenon - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Mengdi</creatorcontrib><creatorcontrib>Cui, Yaru</creatorcontrib><creatorcontrib>Cheng, Yao</creatorcontrib><creatorcontrib>Wang, Qiaoyun</creatorcontrib><creatorcontrib>Sun, Hongliu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Mengdi</au><au>Cui, Yaru</au><au>Cheng, Yao</au><au>Wang, Qiaoyun</au><au>Sun, Hongliu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The neuroprotective effect and possible therapeutic application of xenon in neurological diseases</atitle><jtitle>Journal of neuroscience research</jtitle><addtitle>J Neurosci Res</addtitle><date>2021-12</date><risdate>2021</risdate><volume>99</volume><issue>12</issue><spage>3274</spage><epage>3283</epage><pages>3274-3283</pages><issn>0360-4012</issn><eissn>1097-4547</eissn><abstract>Xenon is an inert gas with stable chemical properties which is used as an anesthetic. Recent in vitro and in vivo findings indicate that xenon also elicits an excellent neuroprotective effect in subanesthetic concentrations. The mechanisms underlying this primarily involve the attenuation of excitotoxicity and the inhibition of N‐methyl‐d‐aspartic acid (NMDA) receptors and NMDA receptor‐related effects, such as antioxidative effects, reduced activation of microglia, and Ca2+‐dependent mechanisms, as well as the interaction with certain ion channels and glial cells. Based on this strong neuroprotective role, a large number of experimental and clinical studies have confirmed the significant therapeutic effect of xenon in the treatment of neurological diseases. 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| subjects | Anesthetics, Inhalation - pharmacology Aspartic acid Attenuation Calcium ions Chemical properties Excitotoxicity Glial cells Glutamic acid receptors (ionotropic) Health services Ion channels Microglia N-Methyl-D-aspartic acid receptors neurological disease Neurological diseases Neuronal-glial interactions Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Rare gases Receptors Receptors, N-Methyl-D-Aspartate Xenon Xenon - pharmacology Xenon - therapeutic use |
| title | The neuroprotective effect and possible therapeutic application of xenon in neurological diseases |
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