Triterpenoid saponins from the leaves and stems of Pericampylus glaucus and their insulin mimetic activities

[Display omitted] •Thirteen new triterpenoid saponins (1–13) were isolated from the leaves and stems from Pericampylus glaucus.•All isolated compounds were evaluated their anti-diabetic effect by the glucose uptake of 2-NBDG in 3T3-L1 adipocytes.•Compounds 4, 7, 11, and 12 exhibited stimulatory effe...

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Veröffentlicht in:	Bioorganic chemistry 2021-12, Vol.117, p.105445-105445, Article 105445
Hauptverfasser:	Lee, Hee-Ju, Cho, Hyo-Moon, Park, Eun-Jin, Lee, Ba-Wool, Nghiem, Duc-Trong, Pham, Ha-Thanh-Tung, Pan, Cheol-Ho, Oh, Won-Keun
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Animals Dose-Response Relationship, Drug Glucose - metabolism Glucose uptake Hypoglycemic Agents - chemistry Hypoglycemic Agents - isolation & purification Hypoglycemic Agents - pharmacology Insulin - metabolism Insulin mimetic activities Menispermaceae Menispermaceae - chemistry Mice Molecular Structure Pericampylus glaucus Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Leaves - chemistry Plant Stems - chemistry Saponins - chemistry Saponins - isolation & purification Saponins - pharmacology Structure-Activity Relationship Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology Triterpenoid saponins
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