Genotype I African swine fever viruses emerged in domestic pigs in China and caused chronic infection
The Georgia-07-like genotype II African swine fever virus (ASFV) with high virulence has been prevalent in China since 2018. Here, we report that genotype I ASFVs have now also emerged in China. Two non-haemadsorbing genotype I ASFVs, HeN/ZZ-P1/21 and SD/DY-I/21, were isolated from pig farms in Hena...
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| Veröffentlicht in: | Emerging microbes & infections 2021-01, Vol.10 (1), p.2183-2193 |
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| creator | Sun, Encheng Huang, Lianyu Zhang, Xianfeng Zhang, Jiwen Shen, Dongdong Zhang, Zhenjiang Wang, Zilong Huo, Hong Wang, Wenqing Huangfu, Haoyue Wang, Wan Li, Fang Liu, Renqiang Sun, Jianhong Tian, Zhijun Xia, Wei Guan, Yuntao He, Xijun Zhu, Yuanmao Zhao, Dongming Bu, Zhigao |
| description | The Georgia-07-like genotype II African swine fever virus (ASFV) with high virulence has been prevalent in China since 2018. Here, we report that genotype I ASFVs have now also emerged in China. Two non-haemadsorbing genotype I ASFVs, HeN/ZZ-P1/21 and SD/DY-I/21, were isolated from pig farms in Henan and Shandong province, respectively. Phylogenetic analysis of the whole genome sequences suggested that both isolates share high similarity with NH/P68 and OURT88/3, two genotype I ASFVs isolated in Portugal in the last century. Animal challenge testing revealed that SD/DY-I/21 shows low virulence and efficient transmissibility in pigs, and causes mild onset of infection and chronic disease. SD/DY-I/21 was found to cause necrotic skin lesions and joint swelling. The emergence of genotype I ASFVs will present more problems and challenges for the control and prevention of African swine fever in China. |
| doi_str_mv | 10.1080/22221751.2021.1999779 |
| format | Article |
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Here, we report that genotype I ASFVs have now also emerged in China. Two non-haemadsorbing genotype I ASFVs, HeN/ZZ-P1/21 and SD/DY-I/21, were isolated from pig farms in Henan and Shandong province, respectively. Phylogenetic analysis of the whole genome sequences suggested that both isolates share high similarity with NH/P68 and OURT88/3, two genotype I ASFVs isolated in Portugal in the last century. Animal challenge testing revealed that SD/DY-I/21 shows low virulence and efficient transmissibility in pigs, and causes mild onset of infection and chronic disease. SD/DY-I/21 was found to cause necrotic skin lesions and joint swelling. The emergence of genotype I ASFVs will present more problems and challenges for the control and prevention of African swine fever in China.</description><identifier>ISSN: 2222-1751</identifier><identifier>EISSN: 2222-1751</identifier><identifier>DOI: 10.1080/22221751.2021.1999779</identifier><identifier>PMID: 34709128</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>African Swine Fever - epidemiology ; African Swine Fever - transmission ; African Swine Fever - virology ; African swine fever virus ; African Swine Fever Virus - classification ; African Swine Fever Virus - genetics ; African Swine Fever Virus - isolation & purification ; African Swine Fever Virus - pathogenicity ; Animals ; China ; China - epidemiology ; Genome, Viral ; Genotype ; genotype I ; Original ; Phylogeny ; pig ; Sus scrofa - virology ; Swine ; Virulence</subject><ispartof>Emerging microbes & infections, 2021-01, Vol.10 (1), p.2183-2193</ispartof><rights>2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd 2021</rights><rights>2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd 2021 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-a7c0907f461a7216fba38f9fbb7b29441885389751a49c15e21d8530c95ba95e3</citedby><cites>FETCH-LOGICAL-c534t-a7c0907f461a7216fba38f9fbb7b29441885389751a49c15e21d8530c95ba95e3</cites><orcidid>0000-0001-7161-6214 ; 0000-0001-9242-4211</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635679/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635679/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,27479,27901,27902,53766,53768,59116,59117</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34709128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Encheng</creatorcontrib><creatorcontrib>Huang, Lianyu</creatorcontrib><creatorcontrib>Zhang, Xianfeng</creatorcontrib><creatorcontrib>Zhang, Jiwen</creatorcontrib><creatorcontrib>Shen, Dongdong</creatorcontrib><creatorcontrib>Zhang, Zhenjiang</creatorcontrib><creatorcontrib>Wang, Zilong</creatorcontrib><creatorcontrib>Huo, Hong</creatorcontrib><creatorcontrib>Wang, Wenqing</creatorcontrib><creatorcontrib>Huangfu, Haoyue</creatorcontrib><creatorcontrib>Wang, Wan</creatorcontrib><creatorcontrib>Li, Fang</creatorcontrib><creatorcontrib>Liu, Renqiang</creatorcontrib><creatorcontrib>Sun, Jianhong</creatorcontrib><creatorcontrib>Tian, Zhijun</creatorcontrib><creatorcontrib>Xia, Wei</creatorcontrib><creatorcontrib>Guan, Yuntao</creatorcontrib><creatorcontrib>He, Xijun</creatorcontrib><creatorcontrib>Zhu, Yuanmao</creatorcontrib><creatorcontrib>Zhao, Dongming</creatorcontrib><creatorcontrib>Bu, Zhigao</creatorcontrib><title>Genotype I African swine fever viruses emerged in domestic pigs in China and caused chronic infection</title><title>Emerging microbes & infections</title><addtitle>Emerg Microbes Infect</addtitle><description>The Georgia-07-like genotype II African swine fever virus (ASFV) with high virulence has been prevalent in China since 2018. 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Here, we report that genotype I ASFVs have now also emerged in China. Two non-haemadsorbing genotype I ASFVs, HeN/ZZ-P1/21 and SD/DY-I/21, were isolated from pig farms in Henan and Shandong province, respectively. Phylogenetic analysis of the whole genome sequences suggested that both isolates share high similarity with NH/P68 and OURT88/3, two genotype I ASFVs isolated in Portugal in the last century. Animal challenge testing revealed that SD/DY-I/21 shows low virulence and efficient transmissibility in pigs, and causes mild onset of infection and chronic disease. SD/DY-I/21 was found to cause necrotic skin lesions and joint swelling. The emergence of genotype I ASFVs will present more problems and challenges for the control and prevention of African swine fever in China.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>34709128</pmid><doi>10.1080/22221751.2021.1999779</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-7161-6214</orcidid><orcidid>https://orcid.org/0000-0001-9242-4211</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | African Swine Fever - epidemiology African Swine Fever - transmission African Swine Fever - virology African swine fever virus African Swine Fever Virus - classification African Swine Fever Virus - genetics African Swine Fever Virus - isolation & purification African Swine Fever Virus - pathogenicity Animals China China - epidemiology Genome, Viral Genotype genotype I Original Phylogeny pig Sus scrofa - virology Swine Virulence |
| title | Genotype I African swine fever viruses emerged in domestic pigs in China and caused chronic infection |
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