Short‐Chain Fatty Acids Produced by Ruminococcaceae Mediate α‐Linolenic Acid Promote Intestinal Stem Cells Proliferation
Scope: The proliferation and differentiation of intestinal stem cells (ISCs) are the basis of intestinal renewal and regeneration, and gut microbiota plays an important role in it. Dietary nutrition has the effect of regulating the activity of ISCs; however, the regulation effect of α‐linolenic acid...
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| Veröffentlicht in: | Molecular nutrition & food research 2022-01, Vol.66 (1), p.e2100408-n/a |
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| creator | Xie, Jing Li, Ling‐fei Dai, Tian‐yi Qi, Xin Wang, Yan Zheng, Tiao‐zhen Gao, Xiao‐yu Zhang, Yun‐juan Ai, Yu Ma, Li Chang, Song‐lin Luo, Feng‐xian Tian, Yang Sheng, Jun |
| description | Scope: The proliferation and differentiation of intestinal stem cells (ISCs) are the basis of intestinal renewal and regeneration, and gut microbiota plays an important role in it. Dietary nutrition has the effect of regulating the activity of ISCs; however, the regulation effect of α‐linolenic acid (ALA) has seldom been reported.
Methods and Results: After intervening mice with different doses of ALA for 30 days, it is found that ALA (0.5 g kg−1) promotes small intestinal and villus growth by activating the Wnt/β‐catenin signaling pathway to stimulate the proliferation of ISCs. Furthermore, ALA administration increases the abundance of the Ruminococcaceae and Prevotellaceae, and promotes the production of short‐chain fatty acids (SCFAs). Subsequent fecal transplantation and antibiotic experiments demonstrate that ALA on the proliferation of ISCs are gut microbiota dependent, among them, the functional microorganism may be derived from Ruminococcaceae. Administration of isobutyrate shows a similar effect to ALA in terms of promoting ISCs proliferation. Furthermore, ALA mitigates 5‐fluorouracil‐induced intestinal mucosal damage by promoting ISCs proliferation.
Conclusion: These results indicate that SCFAs produced by Ruminococcaceae mediate ALA promote ISCs proliferation by activating the Wnt/β‐catenin signaling pathway, and suggest the possibility of ALA as a prebiotic agent for the prevention and treatment of intestinal mucositis.
In this work, it is shown that short‐chain fatty acids (SCFAs) produced by Ruminococcaceae mediate α‐linolenic acid (ALA) promote intestinal stem cells (ISCs) proliferation by activating the Wnt/β‐catenin signaling pathway, and suggest the possibility of ALA as a prebiotic agent for the prevention and treatment of intestinal mucositis. |
| doi_str_mv | 10.1002/mnfr.202100408 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2587746735</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2587746735</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3680-cd3760780e0c5bf951da680c74c050df3bcb2dc9c4b5492b49775518a3fe61b3</originalsourceid><addsrcrecordid>eNqFkT1u3DAQhYnAQfyTtC4NAm7S7Ia_olQai6xjYJ0EtnuBGo5gGpLokBKCLQL4CL6KL5JD-CThep0t0qQazsz3HoZ4hBxzNueMiU_90Ma5YCI3ipVvyAEvuJwpLuXe7i30PjlM6Y4xyYWS78i-VIaVWokD8uv6NsTx-eFxcWv9QJd2HNf0DLxL9HsMbgJ0tFnTq6n3Q4AAYAEt0kt03o5Ifz9l6SqvOhw8vAg3uj7k3cUwYhr9YDt6PWJPF9h1L66dbzHa0YfhPXnb2i7hh9d6RG6Wn28WX2arb-cXi7PVDGRRshk4aQpmSoYMdNNWmjub52AUMM1cKxtohIMKVKNVJRpVGaM1L61sseCNPCIft7b3MfyY8lF17xPkc-yAYUq10KUxqjBSZ_T0H_QuTDH_IVMFL4VQrJKZmm8piCGliG19H31v47rmrN7kUm9yqXe5ZMHJq-3U9Oh2-N8gMqC2wE_f4fo_dvXl1-VVzpXJP8kKm9g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2618224093</pqid></control><display><type>article</type><title>Short‐Chain Fatty Acids Produced by Ruminococcaceae Mediate α‐Linolenic Acid Promote Intestinal Stem Cells Proliferation</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Xie, Jing ; Li, Ling‐fei ; Dai, Tian‐yi ; Qi, Xin ; Wang, Yan ; Zheng, Tiao‐zhen ; Gao, Xiao‐yu ; Zhang, Yun‐juan ; Ai, Yu ; Ma, Li ; Chang, Song‐lin ; Luo, Feng‐xian ; Tian, Yang ; Sheng, Jun</creator><creatorcontrib>Xie, Jing ; Li, Ling‐fei ; Dai, Tian‐yi ; Qi, Xin ; Wang, Yan ; Zheng, Tiao‐zhen ; Gao, Xiao‐yu ; Zhang, Yun‐juan ; Ai, Yu ; Ma, Li ; Chang, Song‐lin ; Luo, Feng‐xian ; Tian, Yang ; Sheng, Jun</creatorcontrib><description>Scope: The proliferation and differentiation of intestinal stem cells (ISCs) are the basis of intestinal renewal and regeneration, and gut microbiota plays an important role in it. Dietary nutrition has the effect of regulating the activity of ISCs; however, the regulation effect of α‐linolenic acid (ALA) has seldom been reported.
Methods and Results: After intervening mice with different doses of ALA for 30 days, it is found that ALA (0.5 g kg−1) promotes small intestinal and villus growth by activating the Wnt/β‐catenin signaling pathway to stimulate the proliferation of ISCs. Furthermore, ALA administration increases the abundance of the Ruminococcaceae and Prevotellaceae, and promotes the production of short‐chain fatty acids (SCFAs). Subsequent fecal transplantation and antibiotic experiments demonstrate that ALA on the proliferation of ISCs are gut microbiota dependent, among them, the functional microorganism may be derived from Ruminococcaceae. Administration of isobutyrate shows a similar effect to ALA in terms of promoting ISCs proliferation. Furthermore, ALA mitigates 5‐fluorouracil‐induced intestinal mucosal damage by promoting ISCs proliferation.
Conclusion: These results indicate that SCFAs produced by Ruminococcaceae mediate ALA promote ISCs proliferation by activating the Wnt/β‐catenin signaling pathway, and suggest the possibility of ALA as a prebiotic agent for the prevention and treatment of intestinal mucositis.
In this work, it is shown that short‐chain fatty acids (SCFAs) produced by Ruminococcaceae mediate α‐linolenic acid (ALA) promote intestinal stem cells (ISCs) proliferation by activating the Wnt/β‐catenin signaling pathway, and suggest the possibility of ALA as a prebiotic agent for the prevention and treatment of intestinal mucositis.</description><identifier>ISSN: 1613-4125</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.202100408</identifier><identifier>PMID: 34708542</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>5-Fluorouracil ; alpha-Linolenic Acid - metabolism ; alpha-Linolenic Acid - pharmacology ; Animals ; Antibiotics ; Catenin ; Cell differentiation ; Cell Proliferation ; Digestive system ; Fatty acids ; Fatty Acids, Volatile - metabolism ; Gastrointestinal tract ; gut microbiota ; Intestinal microflora ; Intestinal Mucosa - metabolism ; intestinal stem cells ; Intestine ; Intestines ; Linolenic acid ; Mice ; Microbiota ; Mucosa ; Mucositis ; Nutrition ; Regeneration ; Ruminococcaceae ; short‐chain fatty acids ; Signal transduction ; Signaling ; Stem cell transplantation ; Stem cells ; Stem Cells - physiology ; the Wnt/β‐catenin signaling pathway ; Transplantation ; Villus ; Wnt protein ; α‐linolenic acid</subject><ispartof>Molecular nutrition & food research, 2022-01, Vol.66 (1), p.e2100408-n/a</ispartof><rights>2021 Wiley‐VCH GmbH</rights><rights>2021 Wiley-VCH GmbH.</rights><rights>2022 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3680-cd3760780e0c5bf951da680c74c050df3bcb2dc9c4b5492b49775518a3fe61b3</citedby><cites>FETCH-LOGICAL-c3680-cd3760780e0c5bf951da680c74c050df3bcb2dc9c4b5492b49775518a3fe61b3</cites><orcidid>0000-0002-8433-1864</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmnfr.202100408$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmnfr.202100408$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34708542$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xie, Jing</creatorcontrib><creatorcontrib>Li, Ling‐fei</creatorcontrib><creatorcontrib>Dai, Tian‐yi</creatorcontrib><creatorcontrib>Qi, Xin</creatorcontrib><creatorcontrib>Wang, Yan</creatorcontrib><creatorcontrib>Zheng, Tiao‐zhen</creatorcontrib><creatorcontrib>Gao, Xiao‐yu</creatorcontrib><creatorcontrib>Zhang, Yun‐juan</creatorcontrib><creatorcontrib>Ai, Yu</creatorcontrib><creatorcontrib>Ma, Li</creatorcontrib><creatorcontrib>Chang, Song‐lin</creatorcontrib><creatorcontrib>Luo, Feng‐xian</creatorcontrib><creatorcontrib>Tian, Yang</creatorcontrib><creatorcontrib>Sheng, Jun</creatorcontrib><title>Short‐Chain Fatty Acids Produced by Ruminococcaceae Mediate α‐Linolenic Acid Promote Intestinal Stem Cells Proliferation</title><title>Molecular nutrition & food research</title><addtitle>Mol Nutr Food Res</addtitle><description>Scope: The proliferation and differentiation of intestinal stem cells (ISCs) are the basis of intestinal renewal and regeneration, and gut microbiota plays an important role in it. Dietary nutrition has the effect of regulating the activity of ISCs; however, the regulation effect of α‐linolenic acid (ALA) has seldom been reported.
Methods and Results: After intervening mice with different doses of ALA for 30 days, it is found that ALA (0.5 g kg−1) promotes small intestinal and villus growth by activating the Wnt/β‐catenin signaling pathway to stimulate the proliferation of ISCs. Furthermore, ALA administration increases the abundance of the Ruminococcaceae and Prevotellaceae, and promotes the production of short‐chain fatty acids (SCFAs). Subsequent fecal transplantation and antibiotic experiments demonstrate that ALA on the proliferation of ISCs are gut microbiota dependent, among them, the functional microorganism may be derived from Ruminococcaceae. Administration of isobutyrate shows a similar effect to ALA in terms of promoting ISCs proliferation. Furthermore, ALA mitigates 5‐fluorouracil‐induced intestinal mucosal damage by promoting ISCs proliferation.
Conclusion: These results indicate that SCFAs produced by Ruminococcaceae mediate ALA promote ISCs proliferation by activating the Wnt/β‐catenin signaling pathway, and suggest the possibility of ALA as a prebiotic agent for the prevention and treatment of intestinal mucositis.
In this work, it is shown that short‐chain fatty acids (SCFAs) produced by Ruminococcaceae mediate α‐linolenic acid (ALA) promote intestinal stem cells (ISCs) proliferation by activating the Wnt/β‐catenin signaling pathway, and suggest the possibility of ALA as a prebiotic agent for the prevention and treatment of intestinal mucositis.</description><subject>5-Fluorouracil</subject><subject>alpha-Linolenic Acid - metabolism</subject><subject>alpha-Linolenic Acid - pharmacology</subject><subject>Animals</subject><subject>Antibiotics</subject><subject>Catenin</subject><subject>Cell differentiation</subject><subject>Cell Proliferation</subject><subject>Digestive system</subject><subject>Fatty acids</subject><subject>Fatty Acids, Volatile - metabolism</subject><subject>Gastrointestinal tract</subject><subject>gut microbiota</subject><subject>Intestinal microflora</subject><subject>Intestinal Mucosa - metabolism</subject><subject>intestinal stem cells</subject><subject>Intestine</subject><subject>Intestines</subject><subject>Linolenic acid</subject><subject>Mice</subject><subject>Microbiota</subject><subject>Mucosa</subject><subject>Mucositis</subject><subject>Nutrition</subject><subject>Regeneration</subject><subject>Ruminococcaceae</subject><subject>short‐chain fatty acids</subject><subject>Signal transduction</subject><subject>Signaling</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Stem Cells - physiology</subject><subject>the Wnt/β‐catenin signaling pathway</subject><subject>Transplantation</subject><subject>Villus</subject><subject>Wnt protein</subject><subject>α‐linolenic acid</subject><issn>1613-4125</issn><issn>1613-4133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkT1u3DAQhYnAQfyTtC4NAm7S7Ia_olQai6xjYJ0EtnuBGo5gGpLokBKCLQL4CL6KL5JD-CThep0t0qQazsz3HoZ4hBxzNueMiU_90Ma5YCI3ipVvyAEvuJwpLuXe7i30PjlM6Y4xyYWS78i-VIaVWokD8uv6NsTx-eFxcWv9QJd2HNf0DLxL9HsMbgJ0tFnTq6n3Q4AAYAEt0kt03o5Ifz9l6SqvOhw8vAg3uj7k3cUwYhr9YDt6PWJPF9h1L66dbzHa0YfhPXnb2i7hh9d6RG6Wn28WX2arb-cXi7PVDGRRshk4aQpmSoYMdNNWmjub52AUMM1cKxtohIMKVKNVJRpVGaM1L61sseCNPCIft7b3MfyY8lF17xPkc-yAYUq10KUxqjBSZ_T0H_QuTDH_IVMFL4VQrJKZmm8piCGliG19H31v47rmrN7kUm9yqXe5ZMHJq-3U9Oh2-N8gMqC2wE_f4fo_dvXl1-VVzpXJP8kKm9g</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>Xie, Jing</creator><creator>Li, Ling‐fei</creator><creator>Dai, Tian‐yi</creator><creator>Qi, Xin</creator><creator>Wang, Yan</creator><creator>Zheng, Tiao‐zhen</creator><creator>Gao, Xiao‐yu</creator><creator>Zhang, Yun‐juan</creator><creator>Ai, Yu</creator><creator>Ma, Li</creator><creator>Chang, Song‐lin</creator><creator>Luo, Feng‐xian</creator><creator>Tian, Yang</creator><creator>Sheng, Jun</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8433-1864</orcidid></search><sort><creationdate>202201</creationdate><title>Short‐Chain Fatty Acids Produced by Ruminococcaceae Mediate α‐Linolenic Acid Promote Intestinal Stem Cells Proliferation</title><author>Xie, Jing ; Li, Ling‐fei ; Dai, Tian‐yi ; Qi, Xin ; Wang, Yan ; Zheng, Tiao‐zhen ; Gao, Xiao‐yu ; Zhang, Yun‐juan ; Ai, Yu ; Ma, Li ; Chang, Song‐lin ; Luo, Feng‐xian ; Tian, Yang ; Sheng, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3680-cd3760780e0c5bf951da680c74c050df3bcb2dc9c4b5492b49775518a3fe61b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>5-Fluorouracil</topic><topic>alpha-Linolenic Acid - metabolism</topic><topic>alpha-Linolenic Acid - pharmacology</topic><topic>Animals</topic><topic>Antibiotics</topic><topic>Catenin</topic><topic>Cell differentiation</topic><topic>Cell Proliferation</topic><topic>Digestive system</topic><topic>Fatty acids</topic><topic>Fatty Acids, Volatile - metabolism</topic><topic>Gastrointestinal tract</topic><topic>gut microbiota</topic><topic>Intestinal microflora</topic><topic>Intestinal Mucosa - metabolism</topic><topic>intestinal stem cells</topic><topic>Intestine</topic><topic>Intestines</topic><topic>Linolenic acid</topic><topic>Mice</topic><topic>Microbiota</topic><topic>Mucosa</topic><topic>Mucositis</topic><topic>Nutrition</topic><topic>Regeneration</topic><topic>Ruminococcaceae</topic><topic>short‐chain fatty acids</topic><topic>Signal transduction</topic><topic>Signaling</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Stem Cells - physiology</topic><topic>the Wnt/β‐catenin signaling pathway</topic><topic>Transplantation</topic><topic>Villus</topic><topic>Wnt protein</topic><topic>α‐linolenic acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xie, Jing</creatorcontrib><creatorcontrib>Li, Ling‐fei</creatorcontrib><creatorcontrib>Dai, Tian‐yi</creatorcontrib><creatorcontrib>Qi, Xin</creatorcontrib><creatorcontrib>Wang, Yan</creatorcontrib><creatorcontrib>Zheng, Tiao‐zhen</creatorcontrib><creatorcontrib>Gao, Xiao‐yu</creatorcontrib><creatorcontrib>Zhang, Yun‐juan</creatorcontrib><creatorcontrib>Ai, Yu</creatorcontrib><creatorcontrib>Ma, Li</creatorcontrib><creatorcontrib>Chang, Song‐lin</creatorcontrib><creatorcontrib>Luo, Feng‐xian</creatorcontrib><creatorcontrib>Tian, Yang</creatorcontrib><creatorcontrib>Sheng, Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular nutrition & food research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xie, Jing</au><au>Li, Ling‐fei</au><au>Dai, Tian‐yi</au><au>Qi, Xin</au><au>Wang, Yan</au><au>Zheng, Tiao‐zhen</au><au>Gao, Xiao‐yu</au><au>Zhang, Yun‐juan</au><au>Ai, Yu</au><au>Ma, Li</au><au>Chang, Song‐lin</au><au>Luo, Feng‐xian</au><au>Tian, Yang</au><au>Sheng, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short‐Chain Fatty Acids Produced by Ruminococcaceae Mediate α‐Linolenic Acid Promote Intestinal Stem Cells Proliferation</atitle><jtitle>Molecular nutrition & food research</jtitle><addtitle>Mol Nutr Food Res</addtitle><date>2022-01</date><risdate>2022</risdate><volume>66</volume><issue>1</issue><spage>e2100408</spage><epage>n/a</epage><pages>e2100408-n/a</pages><issn>1613-4125</issn><eissn>1613-4133</eissn><abstract>Scope: The proliferation and differentiation of intestinal stem cells (ISCs) are the basis of intestinal renewal and regeneration, and gut microbiota plays an important role in it. Dietary nutrition has the effect of regulating the activity of ISCs; however, the regulation effect of α‐linolenic acid (ALA) has seldom been reported.
Methods and Results: After intervening mice with different doses of ALA for 30 days, it is found that ALA (0.5 g kg−1) promotes small intestinal and villus growth by activating the Wnt/β‐catenin signaling pathway to stimulate the proliferation of ISCs. Furthermore, ALA administration increases the abundance of the Ruminococcaceae and Prevotellaceae, and promotes the production of short‐chain fatty acids (SCFAs). Subsequent fecal transplantation and antibiotic experiments demonstrate that ALA on the proliferation of ISCs are gut microbiota dependent, among them, the functional microorganism may be derived from Ruminococcaceae. Administration of isobutyrate shows a similar effect to ALA in terms of promoting ISCs proliferation. Furthermore, ALA mitigates 5‐fluorouracil‐induced intestinal mucosal damage by promoting ISCs proliferation.
Conclusion: These results indicate that SCFAs produced by Ruminococcaceae mediate ALA promote ISCs proliferation by activating the Wnt/β‐catenin signaling pathway, and suggest the possibility of ALA as a prebiotic agent for the prevention and treatment of intestinal mucositis.
In this work, it is shown that short‐chain fatty acids (SCFAs) produced by Ruminococcaceae mediate α‐linolenic acid (ALA) promote intestinal stem cells (ISCs) proliferation by activating the Wnt/β‐catenin signaling pathway, and suggest the possibility of ALA as a prebiotic agent for the prevention and treatment of intestinal mucositis.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34708542</pmid><doi>10.1002/mnfr.202100408</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-8433-1864</orcidid></addata></record> |
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| subjects | 5-Fluorouracil alpha-Linolenic Acid - metabolism alpha-Linolenic Acid - pharmacology Animals Antibiotics Catenin Cell differentiation Cell Proliferation Digestive system Fatty acids Fatty Acids, Volatile - metabolism Gastrointestinal tract gut microbiota Intestinal microflora Intestinal Mucosa - metabolism intestinal stem cells Intestine Intestines Linolenic acid Mice Microbiota Mucosa Mucositis Nutrition Regeneration Ruminococcaceae short‐chain fatty acids Signal transduction Signaling Stem cell transplantation Stem cells Stem Cells - physiology the Wnt/β‐catenin signaling pathway Transplantation Villus Wnt protein α‐linolenic acid |
| title | Short‐Chain Fatty Acids Produced by Ruminococcaceae Mediate α‐Linolenic Acid Promote Intestinal Stem Cells Proliferation |
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